by Rod Pearson
Friday, Oct 10, 2025
Game Time: 8:20 pm ET, Sunday, October 12, 2025
Venue: GEHA Field at Arrowhead Stadium, Kansas City, MO
Where to Watch: NBC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Lions +2.5, Chiefs -2.5; Over/Under: 52.5 points
Bet365: Point Spread: Lions +2.5, Chiefs -2.5; Over/Under: 53 points
BetMGM: Point Spread: Lions +2.5, Chiefs -2.5; Over/Under: 53 points
Season Record
Detroit Lions: 4-1 (1st place, NFC North)
Kansas City Chiefs: 2-3 (3rd place, AFC West)
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Detroit Lions: won their last game on the road against the Cincinnati Bengals 37-24.
Kansas City Chiefs: lost their last game on the road against the Jacksonville Jaguars 31-28.
Detroit Lions vs Kansas City Chiefs Preview and Analysis
The Lions are entering this game with a 4-1 record overall and they have a 1-1 record in their divisional games too. They are 2-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Cincinnati Bengals 37-24. Jared Goff was the starting QB and he completed 19/23 passes for 258 passing yards, 3 touchdowns, and 0 interceptions. David Montgomery led the team in rushing yards with 65 and 1 TD. Amon-Ra St. Brown led the receivers with 100 receiving yards on 8 receptions. Amik Robertson led the defense in that game with 6 solo tackles and 0 assisted tackles while Derrick Barnes and Aidan Hutchinson each led the defense in sacks with 1. Amik Robertson and Kerby Joseph each came away with 1 interception for them in that one.
The Chiefs are entering this game with a 2-3 record overall and they have a 0-1 record in their divisional games too. They are 1-1 in their home games, 1-1 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Jacksonville Jaguars 31-28. Patrick Mahomes was the starting QB and he completed 29/41 passes for 318 passing yards, 1 touchdown, and 1 interception. Patrick Mahomes led the team in rushing yards with 60 and 1 TD. Tyquan Thornton led the receivers with 90 receiving yards on 3 receptions. Nick Bolton led the defense in that game with 7 solo tackles and 5 assisted tackles while Jaylen Watson and Charles Omenihu each led the defense in sacks with 1. Trent McDuffie came away with the only interception for them in that one.
Lions vs Chiefs Prediction
The current betting odds have the Lions listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. The Lions have looked great in their games this season with their 4-1 record overall which has them right at the top of the NFC North. They lost their season opener to the Packers and didn't look great in that game, but they have won 4 games in a row now and have looked like one of the best teams in the NFL once again. Meanwhile, the Chiefs haven't looked good in their games this season with their 2-3 record overall which has them lower in the AFC West to start the year. They started the season 0-2 and they just haven't looked right in any of their games. They are off a 31-28 loss to the Jaguars in their last one and that game was on Monday night so they are at a disadvantage here, playing on a shorter week. The offense did look better in their last 2 games, but the defense hasn't looked great now and they are going to give up points to one of the best offenses in the NFL. The Lions are proving that they aren't going anywhere as a powerhouse in the NFC while the Chiefs have struggled all year and are still dealing with the hangover from losing the Super Bowl last season. The best way to place a bet here is on the Lions to cover the spread in this game.
Lions Chiefs Prediction: Our NFL Pick for Sunday, October 12, 2025 (8:20 pm ET start time) is Lions 34 Chiefs 24.
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NFL Betting Trends
Detroit Lions: 6-11 ATS on the road against AFC West division opponents. 11-16 ATS on the road after 3 or more consecutive wins. 6-3 OVER after 3 or more consecutive wins against the spread. 26-16 OVER in all games. 8-3 OVER vs. good offensive teams - scoring 24 or more points/game.
Kansas City Chiefs: 13-6 ATS in games where the line is +3 to -3. 4-1 ATS after a loss by 6 or less points. 8-3 ATS versus good rushing teams - averaging 130 rushing yards/game or more. 23-17 1H OVER after playing on Monday night football.
Key Injuries
Detroit Lions: A. Maddox (CB) Injured - Hamstring. G. Manu (OG) Injured - Knee. T. Decker (OT) Injured - Shoulder. K. Raymond (WR) Injured - Neck. Z. Cunningham (LB) Injured - Hamstring. A. McNeill (DL) Injured - Knee. A. St. Brown (WR) Injured - Wrist. K. Joseph (S) Injured - Knee. B. Branch (CB) Injured - Ankle. T. Arnold (CB) Injured - Shoulder. S. Vaki (RB) Injured - Groin.
Kansas City Chiefs: J. Smith-Schuster (WR) Injured - Knee. X. Worthy (WR) Injured - Shoulder. J. Bassa (LB) Injured - Knee. N. Bolton (LB) Injured - Calf. H. Brown (WR) Injured - Ankle. K. Fulton (CB) Injured - Ankle. K. Hunt (RB) Injured - Calf. P. Mahomes (QB) Injured - Groin. O. Norman-Lott (DL) Injured - Shoulder. C. Omenihu (DL) Injured - Ankle. J. Taylor (OT) Injured - Knee.
Notable Quotes
“We wanted to get him going because I knew this was going to be special for him. He started to break it open in the second half and started wearing down on the defense.” - Dan Campbell after his team’s win against the Bengals in their last game.
“We’ve got to finish that play. It was a fluke play for him to be able to break that many tackles. I put it on us as a defense. We’ve got to finish. We’ve got to bring him down right there.” - Chris Jones after their loss against the Jaguars in their last game.
Starting Lineups
Detroit Lions
WR TeSlaa, Isaac
WR Williams, Jameson
WR St. Brown, Amon-Ra
TE LaPorta, Sam
QB Goff, Jared
RB Gibbs, Jahmyr
Kansas City Chiefs
WR Smith-Schuster, JuJu
WR Worthy, Xavier
WR Brown, Hollywood
TE Kelce, Travis
QB Mahomes, Patrick
RB Pacheco, Isiah
Statistical Leaders
Detroit Lions
Passing: Jared Goff (1,187)
Rushing: Jahmyr Gibbs (325)
Receiving: Amon-Ra St. Brown (407)
Touchdowns: Amon-Ra St. Brown (6)
Kansas City Chiefs
Passing: Patrick Mahomes (1,257)
Rushing: Patrick Mahomes (190)
Receiving: Tyquan Thornton (272)
Touchdowns: Tyquan Thornton (3)
Coaches:
Detroit Lions: Dan Campbell (5th season)
Kansas City Chiefs: Andy Reid (13th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
