Detroit Lions vs Green Bay Packers Prediction, Preview and Odds - 09/07/2025

Game Time: 4:25 pm ET, Sunday, September 7, 2025

Venue:  Lambeau Field, Green Bay, WI 

Where to Watch:  CBS

DraftKings:  Point Spread:  Lions +2.5, Packers -2.5; Over/Under:  47.5 points

Bet365:  Point Spread:  Lions +2.5, Packers -2.5; Over/Under:  47 points

BetMGM:  Point Spread:  Lions +2.5, Packers -2.5; Over/Under:  47.5 points

Detroit Lions:  0-0 (NFC North)

Green Bay Packers:  0-0 (NFC North)

Do not miss out on our expert handicapper analysis! Jim Feist is on a HOT STREAK in the NFL on a 105-87-3 NFL RUN for +$7,960 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Detroit Lions:  N/A

Green Bay Packers:  N/A

The Lions finished last season with a 15-2 record overall and they were 6-0 in their division games too. They had a 7-2 record in their home games and had an 8-0 record in their road games where they will be in this game. Last season, their offense was averaging 33.2 points per game and their defense was allowing an average of 20.1 points per game. Their offense was also averaging 409.5 yards per game and their defense was allowing an average of 342.4 yards per game. Jared Goff led the team in passing yards with 4,629, Jahmyr Gibbs led the team in rushing yards with 1,412, and Amon-Ra St. Brown led the team in receiving yards with 1,263.

The Packers finished last season with an 11-6 record overall and they were 1-5 in their division games too. They had a 6-3 record in their home games and had a 5-3 record in their road games where they will be in this game. Last season, their offense was averaging 27.1 points per game and their defense was allowing an average of 19.9 points per game. Their offense was also averaging 370.8 yards per game and their defense was allowing an average of 314.5 yards per game. Jordan Love led the team in passing yards with 3,389, Josh Jacobs led the team in rushing yards with 1,329, and Jayden Reed led the team in receiving yards with 857.

The current betting odds have the Packers listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. The Packers had a good season last year, going 11-6 overall and making the playoffs, but they were still only the 3rd best team in the NFC North. They went 1-5 in their own division last year, but they have a chance to get rid of that narrative in their season opener. The Packers have had a really young team over the last few years, but this offense has been growing together and they will be looking to take a big step this season. They also had a great defense last year, and that defense just got a lot better with the addition of Micah Parsons. This defense is going to be even better than it was last season and that gives them a big edge at home since their opponent doesn't have a great defense. The Lions had a great season last year, going 15-2 overall and making the playoffs with the number 1 seed in the NFC. They ended up falling short though and a big reason was that defense. They didn't have a terrible defense last season, but they definitely got exposed in their games against top offenses. They did have one of the best offenses in the NFL last year and they are bringing back a majority of that talent so scoring isn't going to be the issue here, but the Packers definitely have the edge now being at home with the better defense. The best way to place a bet here is on the Packers to cover the spread in this game. 

Lions Packers Prediction:  Our NFL Pick for Sunday, September 7, 2025 (4:25 pm ET start time) is Packers 31 Lions 27.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Detroit Lions Green Bay Packers prediction, be sure to drop by every day for our weekly NFL predictions and previews.

Detroit Lions: 26-12 ATS in all games. 15-3 ATS in road games. 9-4 ATS in games where the line is +3 to -3. 23-14 OVER in all games. 15-6 OVER in all games where the total is between 42.5 and 49 points. 

Green Bay Packers: 1-5 ATS at home versus division opponents. 2-4 1H ATS in a home game where the total is greater than or equal to 45.5. 8-4 OVER versus division opponents. 7-3 1H OVER as a home favorite.

Detroit Lions:  None.

Green Bay Packers:  None.

"If you love football, you love going to play there. And so our guys look forward to it, man. It’s one of those special places to go play.” - Dan Campbell on his team opening the season at Lambeau Field.

“I think for us, when you have opportunities, you’ve got to make the plays, make the calls, and put the guys in the right spot. Unfortunately, last year in that game, it’s 16-10 in the fourth quarter. We needed a stop, we didn’t get it, then we turned the ball over, and there you have it.” - Matt LaFleur on how his team needs to improve this season. 

WR TeSlaa, Isaac

WR Williams, Jameson

WR St. Brown, Amon-Ra

TE LaPorta, Sam

QB Goff, Jared

RB Gibbs, Jahmyr

WR Doubs, Romeo

WR Golden, Matthew

WR Reed, Jayden

TE Kraft, Tucker

QB Love, Jordan

RB Jacobs, Josh

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Detroit Lions: Dan Campbell (5th season)

Green Bay Packers: Matt LaFleur (7th season)