Detroit Lions vs Cincinnati Bengals Prediction, Preview and Odds - 10/05/2025

Game Time: 4:25 pm ET, Sunday, October 5, 2025

Venue:  Paycor Stadium, Cincinnati, OH

Where to Watch:  FOX

DraftKings:  Point Spread:  Lions -10.5, Bengals +10.5; Over/Under:  49.5 points

Bet365:  Point Spread:  Lions -10, Bengals +10; Over/Under:  49.5 points

BetMGM:  Point Spread:  Lions -10.5, Bengals +10.5; Over/Under:  49.5 points

Detroit Lions:  3-1 (1st place, NFC North)

Cincinnati Bengals:  2-2 (2nd place, AFC North)

Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in the NFL on a 27-19-1 NFL RUN for +$6,300 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Detroit Lions:  won their last game at home against the Cleveland Browns 34-10.

Cincinnati Bengals:  lost their last game on the road against the Denver Broncos 28-3.

The Lions are entering this game with a 3-1 record overall and they have a 1-1 record in their divisional games too. They are 2-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Cleveland Browns 34-10. Jared Goff was the starting QB and he completed 16/27 passes for 168 passing yards, 2 touchdowns, and 1 interception. Jahmyr Gibbs led the team in rushing yards with 91 and 1 TD. Amon-Ra St. Brown led the receivers with 70 receiving yards on 7 receptions and 2 TDs. Jack Campbell led the defense in that game with 7 solo tackles and 3 assisted tackles while Aidan Hutchinson led the defense in sacks with 2. D.J. Reed and Kerby Joseph each came away with 1 interception for them in that one.

 

 

 

The Bengals are entering this game with a 2-2 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Denver Broncos 28-3. Jake Browning was the starting QB and he completed 14/25 passes for 125 passing yards, 0 touchdowns, and 0 interceptions. Chase Brown led the team in rushing yards with 40. Tee Higgins led the receivers with 32 receiving yards on 3 receptions. Demetrius Knight Jr. led the defense in that game with 6 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. Demetrius Knight Jr. came away with the only interception for them in that one.

The current betting odds have the Lions listed as a 10.5 point favorite in this game according to Draftkings Sportsbook. The Lions have looked great in their games this season with their 3-1 record overall which has them right at the top of the NFC North. They lost their season opener to the Packers, but they have won 3 games in a row now and have a ton of momentum on their side with these blow out wins. Their offense has been rolling in every game since that season opener, and their defense has looked a lot better this season too. Meanwhile, the Bengals haven't looked good in their games this season with their 2-2 record overall. They had a great 2-0 start to the season, but they lost Joe Burrow to an injury and it has all been downhill since then. Now they have lost 2 games in a row and their offense has been terrible in both games, putting up 13 combined points in those 2 losses. They have also been blown out in their last 2 games with their defense looking just as bad as it was last season. The Bengals are a disaster right now while the Lions are rolling over their opponents, and this game will be no different as they beat up on another bad team. The best way to place a bet here is on the Lions to cover the spread in this game. 

Lions Bengals Prediction:  Our NFL Pick for Sunday, October 5, 2025 (4:25 pm ET start time) is Lions 38 Bengals 10.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Detroit Lions Cincinnati Bengals prediction, be sure to drop by every day for our weekly NFL predictions and previews.

Detroit Lions: 29-13 ATS in all games. 11-2 ATS as a road favorite. 16-6 ATS after scoring 30 points or more last game. 9-2 ATS after a game with a turnover margin of +2 or better. 25-16 OVER in all games. 8-4 OVER after a win by 14 or more points.

Cincinnati Bengals: 4-8 ATS as an underdog. 2-7 ATS off a road loss. 22-29 ATS against teams with a turnover margin of +1 per game or better. 23-15 OVER in all games. 8-3 OVER in a home game where the total is greater than or equal to 45.5. 5-1 OVER vs. good teams - outscoring opponents by 6+ PPG on the season.

Detroit Lions:  T. Decker (OT) Injured - Shoulder. Z. Cunningham (LB) Injured - Hamstring. D. Reed (CB) Injured - Hamstring. A. McNeill (DL) Injured - Knee. K. Dorsey (CB) Injured - Concussion. K. Joseph (S) Injured - Knee. T. Arnold (CB) Injured - Shoulder. S. Vaki (RB) Injured - Groin.

Cincinnati Bengals:  N. Fant (TE) Injured - Concussion. C. Jones (WR) Injured - Achilles. S. Stewart (DL) Injured - Ankle.

“That will always be a security blanket. Those two guys, the rapport and connection they have is special.” - Dan Campbell after his team’s win against the Browns in their last game. 

"I've got a ton of confidence in Jake (Browning). I'm unwavering in that. I know that we can do a great job supporting him to where he can go win games for us." - Zac Taylor after his team’s loss against the Broncos in their last game. 

WR Raymond, Kalif

WR Williams, Jameson

WR St. Brown, Amon-Ra

TE LaPorta, Sam

QB Goff, Jared

RB Gibbs, Jahmyr

WR Chase, Ja'Marr

WR Higgins, Tee

WR Iosivas, Andrei

TE Gesicki, Mike

QB Browning, Jake

RB Brown, Chase

Passing: Jared Goff (929)

Rushing: Jahmyr Gibbs (271)

Receiving: Amon-Ra St. Brown (307)

Touchdowns: Amon-Ra St. Brown (6)

Passing: Jake Browning (506)

Rushing: Chase Brown (133)

Receiving: Ja'Marr Chase (264)

Touchdowns: Chase Brown (1)

Coaches:

Detroit Lions: Dan Campbell (5th season)

Cincinnati Bengals: Zac Taylor (7th season)