Detroit Lions vs Baltimore Ravens Prediction, Preview and Odds - 09/22/2025

Game Time: 8:15 pm ET, Monday, September 22, 2025

Venue:  M&T Bank Stadium, Baltimore, MD

Where to Watch:  ESPN, ABC

DraftKings:  Point Spread:  Lions +4.5, Ravens -4.5; Over/Under:  52.5 points

Bet365:  Point Spread:  Lions +4.5, Ravens -4.5; Over/Under:  53 points

BetMGM:  Point Spread:  Lions +4.5, Ravens -4.5; Over/Under:  53.5 points

Detroit Lions:  1-1 (3rd place, NFC North)

Baltimore Ravens:  1-1 (2nd place, AFC North)

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Detroit Lions:  won their last game at home against the Chicago Bears 52-21.

Baltimore Ravens:  won their last game at home against the Cleveland Browns 41-17.

The Lions are entering this game with a 1-1 record overall and they have a 1-1 record in their divisional games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Chicago Bears 52-21. Jared Goff was the starting QB and he completed 23/28 passes for 334 passing yards, 5 touchdowns, and 0 interceptions. Jahmyr Gibbs led the team in rushing yards with 94 and 1 TD. Amon-Ra St. Brown led the receivers with 115 receiving yards on 9 receptions and 3 TDs. Brian Branch and Terrion Arnold each led the defense in that game with 6 solo tackles and 0 assisted tackles while Brian Branch, Al-Quadin Muhammad, Aidan Hutchinson, and Marcus Davenport each led the defense in sacks with 1. Kerby Joseph came away with the only interception for them in that one.

 

 

 

The Ravens are entering this game with a 1-1 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Cleveland Browns 41-17. Lamar Jackson was the starting QB and he completed 19/29 passes for 225 passing yards, 4 touchdowns, and 0 interceptions. Derrick Henry led the team in rushing yards with 23. Zay Flowers led the receivers with 75 receiving yards on 7 receptions. Roquan Smith led the defense in that game with 8 solo tackles and 7 assisted tackles while Tavius Robinson and Nnamdi Madubuike each led the defense in sacks with 1. Nate Wiggins came away with the only interception for them in that one.

The current betting odds have the Lions listed as a 4.5 point underdog in this game according to Draftkings Sportsbook. The Lions have a 1-1 record overall this season and they have looked like a different team in both games. They lost their season opener to the Packers 27-13 and that game was never close, but now they are off a 52-21 win over the Bears in their last one. That win over the Bears is going to give them some momentum now and even though their defense hasn't looked great this year, the offense looked back last week and they are going to give the Lions a chance to keep this game close. Meanwhile, the Ravens have a 1-1 record overall and they have looked good in both games. They are off a 41-17 win over the Browns while their loss came in week 1 against the Bills. They had a huge lead against the Bills though and they blew that lead against a really good offense, giving up 41 points in the end and losing the game. The Browns weren't good enough offensively to pull off another comeback against the Ravens last week, but the Lions definitely have the talent in this offense to do so. This is another game where the Ravens are going to need a lot of points to win and in these games against some of the best offenses in the NFL, their defense hasn't shown yet that they can be trusted to keep the lead. The Lions offense is going to give them a chance to win this game and they will never be out of it. The best way to place a bet here is on the Lions to cover the spread in this game. 

Lions Ravens Prediction:  Our NFL Pick for Monday, September 22, 2025 (8:15 pm ET start time) is Ravens 38 Lions 35.

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Detroit Lions: 0-5 ATS off a home win against a division rival. 15-22 1H ATS against AFC North division opponents. 24-15 OVER in all games. 10-2 OVER after playing a division game. 10-5 OVER off a home win.

Baltimore Ravens: 25-15 ATS in all games. 13-7 ATS as a home favorite. 9-4 ATS after playing a division game. 7-3 ATS in non-conference games. 23-15 OVER in all games. 5-1 OVER in all games where the total is greater than or equal to 49.5. 

Detroit Lions:  T. Nowaske (LB) Injured - Elbow. S. Vaki (RB) Injured - Hamstring. J. Campbell (LB) Injured - Ankle. M. Davenport (DL) Injured - Chest. T. Decker (OT) Injured - Shoulder. K. Joseph (S) Injured - Knee.

Baltimore Ravens:  R. Ali (RB) Injured - Concussion. M. Humphrey (CB) Injured - Groin. J. Jenkins (DL) Injured - NIR-Personal. I. Likely (TE) Injured - Foot. N. Madubuike (DL) Injured - Neck. P. Ricard (FB) Injured - Calf. K. Van Noy (LB) Injured - Hamstring. N. Wiggins (CB) Injured - Groin.

“I knew the guys would respond.” - Dan Campbell after his team’s win against the Bears in their last game. 

“That maturing as a football team to win games like that, they did that in this game. This was a tough game. The score doesn't really indicate it, but this was a grind of a football game.” - John Harbaugh after his team’s win against the Browns in their last game. 

WR Raymond, Kalif

WR Williams, Jameson

WR St. Brown, Amon-Ra

TE LaPorta, Sam

QB Goff, Jared

RB Gibbs, Jahmyr

WR Walker, Devontez

WR Bateman, Rashod

WR Flowers, Zay

TE Andrews, Mark

QB Jackson, Lamar

RB Henry, Derrick

FB Ricard, Patrick

Passing: J. Goff (559)

Rushing: J. Gibbs (113)

Receiving: A. St. Brown (160)

Touchdowns: A. St. Brown (3)

Passing: L. Jackson (434)

Rushing: D. Henry (192)

Receiving: Z. Flowers (218)

Touchdowns: D. Henry (2)

Coaches:

Detroit Lions: Dan Campbell (5th season)

Baltimore Ravens: John Harbaugh (18th season)