Denver Broncos vs Philadelphia Eagles Prediction, Preview and Odds - 10/05/2025

Game Time: 1:00 pm ET, Sunday, October 5, 2025

Venue:  Lincoln Financial Field, Philadelphia, PA

Where to Watch:  CBS

DraftKings:  Point Spread:  Broncos +4.5, Eagles -4.5; Over/Under:  43.5 points

Bet365:  Point Spread:  Broncos +4, Eagles -4; Over/Under:  43.5 points

BetMGM:  Point Spread:  Broncos +4.5, Eagles -4.5; Over/Under:  44 points

Denver Broncos:  2-2 (3rd place, AFC West)

Philadelphia Eagles:  4-0 (1st place, NFC East)

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Denver Broncos:  won their last game at home against the Cincinnati Bengals 28-3.

Philadelphia Eagles:  won their last game on the road against the Tampa Bay Buccaneers 31-25.

The Broncos are entering this game with a 2-2 record overall and they have a 0-1 record in their divisional games too. They are 2-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Cincinnati Bengals 28-3. Bo Nix was the starting QB and he completed 29/42 passes for 326 passing yards, 2 touchdowns, and 1 interception. J.K. Dobbins led the team in rushing yards with 101. Courtland Sutton led the receivers with 81 receiving yards on 5 receptions and 1 TD. Alex Singleton led the defense in that game with 6 solo tackles and 5 assisted tackles while Nik Bonitto led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.

 

 

 

The Eagles are entering this game with a 4-0 record overall and they have a 1-0 record in their divisional games too. They are 2-0 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Tampa Bay Buccaneers 31-25. Jalen Hurts was the starting QB and he completed 15/24 passes for 130 passing yards, 2 touchdowns, and 0 interceptions. Jalen Hurts led the team in rushing yards with 62. Dallas Goedert led the receivers with 37 receiving yards on 4 receptions and 2 TDs. Cooper DeJean led the defense in that game with 8 solo tackles and 1 assisted tackle while Zack Baun and Moro Ojomo each led the defense in sacks with 1. Jihaad Campbell came away with the only interception for them in that one.

The current betting odds have the Eagles listed as a 4.5 point favorite in this game according to Draftkings Sportsbook. The Eagles have looked great in their games this season with their 4-0 record overall which has them right at the top of the NFC East with one of the only undefeated records left in the NFL. They are off a 31-25 win over the Buccaneers in their last one and they are starting to gain some momentum with the way they have won their last 2 games. The offense hasn't looked great this season, but they have been getting better in their last 2 games and they are a really tough team to stop with all of that talent once they get going. Meanwhile, the Broncos haven't looked great in their games this season with their 2-2 record overall. This isn't the start to the season they were expecting as they have dropped some closer games to good opponents. They are off a 28-3 win over the Bengals in their last one, but that wasn't a solid win with the state that the Bengals are in right now. The Broncos have struggled against the 2 good teams they have faced this season and this is going to be their toughest test against the defending Super Bowl champions. This is not an easy situation for them either, going on the road against the defending champions on a short week after playing a game on Monday Night Football. The Eagles are going to continue to roll in this one and stay undefeated. The best way to place a bet here is on the Eagles to cover the spread in this game. 

Broncos Eagles Prediction:  Our NFL Pick for Sunday, October 5, 2025 (1:00 pm ET start time) is Eagles 31 Broncos 24.

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Denver Broncos: 4-7 ATS as a road underdog of 7 points or less. 3-8 ATS in a road game where the total is between 42.5 and 49 points. 14-6 UNDER in all games where the total is between 42.5 and 49 points. 5-0 UNDER when playing against a top-level team (Win Pct. > 75%). 

Philadelphia Eagles: 24-17 ATS in all games. 9-2 ATS as a home favorite of 7 points or less. 11-3 ATS vs. good offensive teams - scoring 24 or more points/game. 6-3 UNDER vs. good teams - outscoring opponents by 6+ PPG on the season.

Denver Broncos:  A. Singleton (LB) Injured - Thumb. N. Adkins (TE) Injured - Concussion. N. Bonitto (LB) Injured - Wrist. M. Mims Jr. (WR) Injured - Hip. J. Elliss (LB) Injured - Ribs.

Philadelphia Eagles:  J. Carter (DL) Injured - Shoulder. N. Dean (LB) Injured - Knee. A. Jackson (CB) Injured - Groin. L. Johnson (OT) Injured - Shoulder.

“It’s an o-zone situation, that last touchdown, Bo kind of bailed me out. We were in 01 personnel, so the play has to go to the end zone. We don’t really want the play clock to be running so it’s out of bounds or the end zone. It was a great call by him and a great throw and catch by Sutton. You start those drives thinking field goal, be smart, we start the second half with the ball. And then you midstream adjust, and quickly we were across midfield, and now your mindset adjusts. Certainly a big play at the end of the half, a huge play.” - Sean Payton after his team’s win against the Bengals in their last game. 

“It’s a great team win. Another gritty win. We know this has been a challenging environment. I’m proud of the way we competed. A lot we can improve on but it’s always good to get a win out there and they don’t come easy.” - Jalen Hurts after their win against the Bucs in their last game. 

WR Sutton, Courtland

WR Mims Jr., Marvin

WR Franklin, Troy

TE Trautman, Adam

QB Nix, Bo

RB Dobbins, J.K.

FB Prentice, Adam

WR Brown, A.J. 

WR Dotson, Jahan

WR Smith, DeVonta

TE Goedert, Dallas

QB Hurts, Jalen

RB Barkley, Saquon

Passing: Bo Nix (861)

Rushing: J.K. Dobbins (323)

Receiving: Courtland Sutton (266)

Touchdowns: J.K. Dobbins (3)

Passing: Jalen Hurts (609)

Rushing: Saquon Barkley (237)

Receiving: DeVonta Smith (158)

Touchdowns: Jalen Hurts (4)

Coaches:

Denver Broncos: Sean Payton (3rd season)

Philadelphia Eagles: Nick Sirianni (5th season)