Denver Broncos vs Indianapolis Colts Prediction, Preview and Odds - 09/14/2025

Game Time: 4:05 pm ET, Sunday, September 14, 2025

Venue:  Lucas Oil Stadium, Indianapolis, IN

Where to Watch:  CBS

DraftKings:  Point Spread:  Broncos -1.5, Colts +1.5; Over/Under:  43.5 points

Bet365:  Point Spread:  Broncos -1, Colts +1; Over/Under:  43.5 points

BetMGM:  Point Spread:  Broncos -1.5, Colts +1.5; Over/Under:  43.5 points

Denver Broncos:  1-0 (2nd place, AFC West)

Indianapolis Colts:  1-0 (1st place, AFC South)

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Denver Broncos:  won their last game at home against the Tennessee Titans 20-12.

Indianapolis Colts:  won their last game at home against the Miami Dolphins 33-8.

The Broncos are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Tennessee Titans 20-12. Bo Nix was the starting QB and he completed 25/40 passes for 176 passing yards, 1 touchdown, and 2 interceptions. RJ Harvey led the team in rushing yards with 70. Courtland Sutton led the receivers with 61 receiving yards on 6 receptions and 1 TD. Talanoa Hufanga led the defense in that game with 7 solo tackles and 4 assisted tackles while Justin Strnad, Nik Bonitto, Jonah Elliss, Jonathon Cooper, Ja'Quan McMillian, and Zach Allen each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Colts are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Miami Dolphins 33-8. Daniel Jones was the starting QB and he completed 22/29 passes for 272 passing yards, 1 touchdown, and 0 interceptions. Jonathan Taylor led the team in rushing yards with 71. Michael Pittman Jr. led the receivers with 80 receiving yards on 6 receptions and 1 TD. Nick Cross and Charvarius Ward each led the defense in that game with 4 solo tackles and 2 assisted tackles while Charvarius Ward, Kenny Moore II, and Samson Ebukam each led the defense in sacks with 1. Camryn Bynum and Laiatu Latu each came away with 1 interception for them in that one.

The current betting odds have the Broncos listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The Broncos have a 1-0 record overall this season, but they didn't look great in week 1. They beat the Titans 20-12 at home and the Titans are one of the worst teams in the NFL. The offense looked terrible in that game, but the defense was elite as the Broncos do have one of the best defenses in the NFL this year. The defense kept them in that game and they are going to do the same in this one, but the offense should look a lot better in this 2nd game. Bo Nix had a bad game last week, but he was great last year and he will be looking to bounce back with the new talent they have in this offense. Meanwhile, the Colts have a 1-0 record overall and they looked great in their season opener. They beat up on the Dolphins at home 33-8, but the Dolphins also look like a disaster this season. Daniel Jones looked great in his debut for the Colts, but he is not going to have another great game like he did last week against this much better Broncos defense. The Broncos offense will look a lot better in this game and the defense is going to do enough to shut down this Colts offense for 4 quarters. The best way to place a bet here is on the Broncos to cover the spread in this game. 

Broncos Colts Prediction:  Our NFL Pick for Sunday, September 14, 2025 (4:05 pm ET start time) is Broncos 23 Colts 17.

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Denver Broncos: 5-9 ATS in games where the line is +3 to -3. 3-6 ATS in a road game where the total is between 42.5 and 49 points. 4-0 OVER in dome games. 11-6 OVER after 1 or more consecutive wins.

Indianapolis Colts: 13-7 ATS in games where the line is +3 to -3. 16-9 ATS against conference opponents. 12-6 OVER in home games. 9-5 OVER in a home game where the total is between 42.5 and 49 points. 16-8 OVER against conference opponents.

Denver Broncos:  D. Greenlaw (LB) Injured - Quad. A. Singleton (LB) Injured - Thumb. E. Engram (TE) Injured - Calf. N. Adkins (TE) Injured - Ankle. J. Franklin-Myers (DL) Injured - Knee.

Indianapolis Colts:  G. Stewart (DL) Injured - NIR - Rest. T. Goodson (RB) Injured - Elbow. J. Jones (CB) Injured - Hamstring. L. Latu (DL) Injured - Hamstring. A. Pierce (WR) Injured - Knee. M. Pittman Jr. (WR) Injured - Glute. C. Ward (CB) Injured - Concussion.

“The one that really sticks out is they get the ball down 1 and we get two sacks and get them out of field goal range. That'll change the game in a hurry and changes the environment ... It was awesome to see different players making big plays.” - Bo Nix after their win against the Titans in their last game. 

“I just kind of talked about what their dad meant to this organization and then him raising those three daughters and doing it the right way, setting them up for a moment to take over the team. I thought it was just really special and really fitting for them.” - Shane Steichen after his team’s win against the Dolphins in their last game. 

WR Sutton, Courtland

WR Mims Jr., Marvin

WR Franklin, Troy

TE Engram, Evan

QB Nix, Bo

RB Dobbins, J.K.

WR Pittman Jr., Michael

WR Pierce, Alec

WR Downs, Josh

TE Warren, Tyler

QB Jones, Daniel

RB Taylor, Jonathan

Passing: B. Nix (176)

Rushing: R. Harvey (70)

Receiving: C. Sutton (61)

Touchdowns: C. Sutton (1)

Passing: D. Jones (272)

Rushing: J. Taylor (71)

Receiving: M. Pittman Jr. (80)

Touchdowns: D. Jones (2)

Coaches:

Denver Broncos: Sean Payton (3rd season)

Indianapolis Colts: Shane Steichen (3rd season)