Dallas Cowboys vs Philadelphia Eagles Prediction, Preview and Odds - 09/04/2025

Game Time: 8:20 pm ET, Thursday, September 4, 2025

Venue:  Lincoln Financial Field, Philadelphia, PA 

Where to Watch:  NBC, Peacock

DraftKings:  Point Spread:  Cowboys +7, Eagles -7; Over/Under:  46.5 points

Bet365:  Point Spread:  Cowboys +7, Eagles -7; Over/Under:  46 points

BetMGM:  Point Spread:  Cowboys +7, Eagles -7; Over/Under:  46 points

Dallas Cowboys:  0-0 (NFC East)

Philadelphia Eagles:  0-0 (NFC East)

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Dallas Cowboys:  N/A

Philadelphia Eagles:  N/A

The Cowboys finished last season with a 7-10 record overall and they were 3-3 in their division games too. They had a 2-7 record in their home games and had a 5-3 record in their road games where they will be in this game. Last season, their offense was averaging 20.6 points per game and their defense was allowing an average of 27.5 points per game. Their offense was also averaging 327.5 yards per game and their defense was allowing an average of 355.2 yards per game. Dak Prescott led the team in passing yards with 1,978, Rico Dowdle led the team in rushing yards with 1,079, and CeeDee Lamb led the team in receiving yards with 1,194.

The Eagles finished last season with a 14-3 record overall and they were 5-1 in their division games too. They had an 8-1 record in their home games and had a 6-2 record in their road games where they will be in this game. Last season, their offense was averaging 27.2 points per game and their defense was allowing an average of 17.8 points per game. Their offense was also averaging 367.2 yards per game and their defense was allowing an average of 278.4 yards per game. Jalen Hurts led the team in passing yards with 2,903, Saquon Barkley led the team in rushing yards with 2,005, and A.J. Brown led the team in receiving yards with 1,079.

The current betting odds have the Eagles listed as a 7 point favorite in this game according to Draftkings Sportsbook. The Eagles had a great season last year, finishing 14-3 overall with one of the best records in the NFL and they went on to win the Super Bowl over the Kansas City Chiefs. Not only did they take down the back-to-back champions at the time, they also embarrassed them in a game that wasn't even close. The Eagles are now the team to beat in the NFL and they still have lots of talent from that Super Bowl winning team. They will be looking to come out strong in this season opener and pick up right where they left off last season. Meanwhile, the Cowboys had a disaster season that was filled with injuries on both sides of the ball. They went 7-10 overall and failed to make the playoffs, and they don't look to be in any better shape this year. They have a new head coach that doesn't have any experience being the head coach of an NFL team and they also have some off the field distractions with some of their key players. The Cowboys are entering the season healthy again, but one of their best defenders has asked for a trade and that would be a huge blow to the defense if he does not play. The offense still has plenty of talent, but the Eagles also had one of the best defenses in the NFL last season so it won't be easy for the Cowboys to move the ball in this season opener. The Eagles are a machine and this isn't the team that the Cowboys want to see in their 1st game after the season they just had. The best way to place a bet here is on the Eagles to cover the spread in this game. 

Cowboys Eagles Prediction:  Our NFL Pick for Thursday, September 4, 2025 (8:20 pm ET start time) is Eagles 24 Cowboys 10.

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Dallas Cowboys: 6-12 ATS as an underdog. 3-6 ATS as a road underdog of 7 points or less. 6-3 OVER as an underdog of 3.5 to 9.5 points. 8-2 OVER in games played on a grass field. 

Philadelphia Eagles: 8-2 ATS as a home favorite of 7 points or less. 5-2 ATS at home versus division opponents. 9-5 OVER in a home game where the total is between 42.5 and 49 points. 9-4 1H OVER versus division opponents.

Dallas Cowboys:  None.

Philadelphia Eagles:  None.

"It was hard to sit down in front of those guys and be honest and tell them the why, tell them the things they do well, tell them the areas that they can improve. I think that's important because anytime you have those hard conversations, whether they're back or not back, they hopefully can use a thing that they're given the feedback about to improve themselves as a player." - Brian Schottenheimer on the team’s 53-man roster coming into the new NFL season. 

“I felt like it was just not great complimentary football today. When you have the heat like that, you want to be able to — defense had some long drives, offense had some three-and-outs and you want to be able to play complimentary football in that area. I have to watch the tape. Obviously, they had some good moments and had some plays that they made, but also we missed some plays. But, that’s not always just on the quarterback if there was a misplay. I’ll have to go watch the tape. It wasn’t good enough out there on the field today. Coaching, playing, anything.” - Nick Sirianni on the backup QB competition. 

WR Pickens, George

WR Tolbert, Jalen

WR Lamb, CeeDee

TE Ferguson, Jake

QB Prescott, Dak

RB Williams, Javonte

FB Luepke, Hunter

WR Brown, A.J. 

WR Dotson, Jahan

WR Smith, DeVonta

TE Goedert, Dallas

QB Hurts, Jalen

RB Barkley, Saquon

FB VanSumeren, Ben

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Dallas Cowboys: Brian Schottenheimer (1st season)

Philadelphia Eagles: Nick Sirianni (5th season)