by Rod Pearson
Friday, Sep 19, 2025
Game Time: 4:25 pm ET, Sunday, September 21, 2025
Venue: Soldier Field, Chicago, IL
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Cowboys -1.5, Bears +1.5; Over/Under: 50.5 points
Bet365: Point Spread: Cowboys -1, Bears +1; Over/Under: 50.5 points
BetMGM: Point Spread: Cowboys -1, Bears +1; Over/Under: 50.5 points
Season Record
Dallas Cowboys: 1-1 (3rd place, NFC East)
Chicago Bears: 0-2 (4th place, NFC North)
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Recent Form
Dallas Cowboys: won their last game at home against the New York Giants 40-37 in overtime.
Chicago Bears: lost their last game on the road against the Detroit Lions 52-21.
Dallas Cowboys vs Chicago Bears Preview and Analysis
The Cowboys are entering this game with a 1-1 record overall and they have a 1-1 record in their divisional games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New York Giants 40-37 in OT. Dak Prescott was the starting QB and he completed 38/52 passes for 361 passing yards, 2 touchdowns, and 1 interception. Javonte Williams led the team in rushing yards with 97 and 1 TD. CeeDee Lamb led the receivers with 112 receiving yards on 9 receptions. Kaiir Elam led the defense in that game with 6 solo tackles and 3 assisted tackles while Kenny Clark and James Houston each led the defense in sacks with 1. Donovan Wilson came away with the only interception for them in that one.
The Bears are entering this game with a 0-2 record overall and they have a 0-2 record in their divisional games too. They are 0-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Detroit Lions 52-21. Caleb Williams was the starting QB and he completed 19/30 passes for 207 passing yards, 2 touchdowns, and 1 interception. D'Andre Swift led the team in rushing yards with 63 and 1 TD. Rome Odunze led the receivers with 128 receiving yards on 7 receptions and 2 TDs. Jaquan Brisker led the defense in that game with 7 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.
Cowboys vs Bears Prediction
The current betting odds have the Cowboys listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The Cowboys have a 1-1 record overall this season and they haven't looked terrible in their 2 games. They lost their season opener on the road against the Super Bowl champions, but they kept that game respectable in a 4 point loss to the Eagles. Now they are off a 40-37 win in OT over the Giants and their defense made the Giants look like one of the best offenses in the NFL. That defense is going to be a big issue for the Cowboys this season, but their offense has a ton of talent and has looked great in both games so Dak is always going to give his team a chance in these games. Meanwhile, the Bears have a 0-2 record overall and have looked terrible in both games. They lost their season opener to the Vikings in a game that they should have won but blew it late due to their lack of offense, and now they are off a 52-21 loss to the Lions where they were completely embarrassed. Ben Johnson has a lot of work to do in his first season as the Bears still look like a disaster, and Caleb Williams hasn't looked any better than he did last season. The offense will be able to move the ball against this terrible Cowboys defense, but the Bears defense isn't any better and the Cowboys have the more reliable QB and offense to win this game late if it's close. The best way to place a bet here is on the Cowboys to cover the spread in this game.
Cowboys Bears Prediction: Our NFL Pick for Sunday, September 21, 2025 (4:25 pm ET start time) is Cowboys 27 Bears 20.
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NFL Betting Trends
Dallas Cowboys: 11-6 ATS as a favorite. 17-10 ATS in a road game where the total is greater than or equal to 49.5. 37-24 ATS on the road after allowing 30 points or more last game. 17-9 OVER against conference opponents. 9-3 OVER after scoring 30 points or more last game.
Chicago Bears: 6-10 ATS in games where the line is +3 to -3. 4-7 ATS off a road loss. 5-12 ATS in all games where the total is greater than or equal to 49.5. 6-3 OVER off a loss against a division rival.
Key Injuries
Dallas Cowboys: D. Bland (CB) Injured - Foot. T. Diggs (CB) Injured - Illness. T. Guyton (OT) Injured - Shoulder. K. Turpin (WR) Injured - Neck.
Chicago Bears: T. Edwards (LB) Injured - Hamstring. K. Gordon (CB) Injured - Hamstring. G. Jarrett (DL) Injured - Knee. J. Johnson (CB) Injured - Groin. J. Jones (CB) Injured - Hamstring. K. Amegadjie (OG) Injured - Elbow. D. Jackson (LB) Injured - Hamstring. D. Swift (RB) Injured - Quad. J. Walker (WR) Injured - Ankle.
Notable Quotes
“Cool way to win your first game. The words that Dak and the players said to me after the game is why it's so special. I expect the first of many, but I'll remember this one forever because of the fight of these guys.” - Brian Schottenheimer after his team’s win against the Giants in their last game.
“It is not demoralizing at all. We have to play better." - Ben Johnson after his team’s loss against the Lions in their last game.
Starting Lineups
Dallas Cowboys
WR Pickens, George
WR Lamb, CeeDee
WR Tolbert, Jalen
TE Ferguson, Jake
QB Prescott, Dak
RB Williams, Javonte
FB Luepke, Hunter
Chicago Bears
WR Odunze, Rome
WR Moore, DJ
WR Zaccheaus, Olamide
TE Kmet, Cole
QB Williams, Caleb
RB Swift, D'Andre
Statistical Leaders
Dallas Cowboys
Passing: D. Prescott (549)
Rushing: J. Williams (151)
Receiving: C. Lamb (222)
Touchdowns: J. Williams (3)
Chicago Bears
Passing: C. Williams (417)
Rushing: D. Swift (116)
Receiving: R. Odunze (165)
Touchdowns: R. Odunze (3)
Coaches:
Dallas Cowboys: Brian Schottenheimer (1st season)
Chicago Bears: Ben Johnson (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
