Cleveland Guardians vs Milwaukee Brewers Prediction, Preview and Odds - 06/16/2026

Game Time: 7:40 pm ET, Tuesday, June 16, 2026

Venue:  American Family Field, Milwaukee, WI

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Guardians +123, Brewers -149; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Guardians +125, Brewers -150; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Guardians +125, Brewers -155; Over/Under:  8.5 runs

Cleveland Guardians:  39-33 (2nd place, AL Central)

Milwaukee Brewers:  43-26 (1st place, NL Central)

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Cleveland Guardians:  4-6 last 10

Milwaukee Brewers:  6-4 last 10

The Guardians are entering this series off a win and completed the sweep in their 2-game series against the Detroit Tigers 2-0 in their last series. They enter this game with a 39-33 record overall and have a road record of 20-16. This is the series opener of a 3-game series with the Brewers on Tuesday and they have Monday off as a day of rest. Their offense ranks 27th in the MLB with a .689 OPS. Joey Cantillo was their starting pitcher on Sunday while Slade Cecconi is making his start in this game on Tuesday. He is 3-5 with a 4.83 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 1 HR, and 2 BB with 7 SO on 6 hits through 5 IP against the New York Yankees.

The Brewers are entering this series off a win and won their 3-game series against the Philadelphia Phillies 2-1 in their last series. They enter this game with a 43-26 record overall and have a home record of 23-14. This is the 1st game of a 3-game series with the Guardians on Tuesday and they have Monday off as a day of rest. Their offense ranks 8th in the MLB with a .734 OPS. Kyle Harrison was their starting pitcher on Sunday while Robert Gasser is making his start in this game on Tuesday. He is 0-3 with a 6.38 ERA this season. His team lost all 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 6 earned runs, 4 homers, and 2 walks with 7 strikeouts on 8 hits through 5 innings pitched against the Athletics.

The current betting odds have the Guardians listed as an underdog in this game according to Draftkings Sportsbook. The Guardians have looked good in their games this season with their 39-33 record overall which has them right near the top of the AL Central. They have been a good road team too with their 20-16 road record this year. Meanwhile, the Brewers have looked great in their games this season with their 43-26 record overall which has them right at the top of the NL Central with one of the best records in MLB. They have looked great in their own ballpark too with their 23-14 home record this season. The Brewers are 6-4 in their last 10 games and have been rolling lately while the Guardians are 4-6 in their last 10 games and have been cooling off, but the Guardians did sweep the Tigers in their last series and they can definitely take advantage of this pitching matchup. Cecconi is starting for the Guardians in this one and he hasn't looked great this season, but he has looked a lot better lately. He is 3-5 with a 4.35 ERA and he hasn't been giving up as many runs. His team has still lost 2 games in a row with him starting, but he only gave up 2 earned runs in his last start and he has been doing that more lately. The Brewers are going with Gasser in this one and he hasn't looked good this season. He is 0-3 with a 6.38 ERA and his team hasn't been having a lot of success with him. They have lost all 4 games this season that he pitched in and he is coming off another bad start in which he gave up 6 earned runs. The Brewers offense has looked a lot better lately, but it has still been up and down all season and the Guardians do have the better bullpen to steal this game late with the way the Brewers have been giving up runs lately. The best way to place a bet here is on the Guardians to win this game. 

Guardians Brewers Prediction:  Our MLB Pick for Tuesday, June 16, 2026 (7:40 pm ET start time) is Guardians 5 Brewers 4.

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Cleveland Guardians: 20-24 (-6 units) on the moneyline against NL Central opponents. 55-60 (-4.9 units) on the moneyline in an inter-league game. 46-63 (-8.3 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 79-47 UNDER as a road underdog of +100 or higher.

Milwaukee Brewers: 30-15 (+15.8 units) on the moneyline against AL Central opponents. 237-169 (+47.4 units) on the moneyline in all games. 125-81 (+18.7 units) on the moneyline in home games. 20-11 UNDER after shutting out their opponent.

Cleveland Guardians:  J. Ramirez (3B) Ten Day IL - Hand. X. Martinez (RP) Day To Day - Foot. C. DeLauter (RF) Day To Day - Rib Cage. E. Sabrowski (RP) Fifteen Day IL - Elbow.

Milwaukee Brewers:  C. Crow (SP) Fifteen Day IL - Forearm. B. Fitzpatrick (RP) Sixty Day IL - Elbow. C. Rodriguez (RP) Fifteen Day IL - Undisclosed. Q. Priester (SP) Sixty Day IL - Wrist. D. Hall (RP) Fifteen Day IL - Pectoral. R. Zastryzny (RP) Fifteen Day IL - Shoulder. A. Zerpa (RP) Sixty Day IL - Forearm. L. Henderson (SP) Fifteen Day IL - Back. B. Lockridge (LF) Ten Day IL - Knee. B. Woodruff (SP) Fifteen Day IL - Arm. J. Koenig (RP) Fifteen Day IL - Elbow.

“We’re trying to rule everything out right now. That’s why we got the two tests. We don’t want to put the cart before the horse with anything until our medical group has had time to review the two tests.” - Stephen Vogt on the injury to Chase DeLauter.

"I’ll tell you what: It’s a good feeling. I don’t think anyone complains about the hitting the ball over the fence. First one of the year. It’s been a while." - Blake Perkins on his home run after their win against the Phillies in their game on Sunday. 

Angel Martínez (S) LF

José Ramírez (S) 3B

Chase DeLauter (L) RF

Rhys Hoskins (R) 1B

David Fry (R) DH

Travis Bazzana (L) 2B

Stuart Fairchild (R) CF

Austin Hedges (R) C

Brayan Rocchio (S) SS

Jackson Chourio (R) LF

Andrew Vaughn (R) 1B

William Contreras (R) DH

Gary Sánchez (R) C

Luis Rengifo (S) 3B

Garrett Mitchell (L) CF

Blake Perkins (S) RF

Joey Ortiz (R) SS

David Hamilton (L) 2B

Batting Average:  Brayan Rocchio (.274)

Hits:  José Ramírez (64)

Home Runs:  Angel Martínez (11)

RBI:  Chase DeLauter (34)

Stolen Bases:  José Ramírez (24)

Wins:  Gavin Williams (9)

Saves:  Cade Smith (23)

ERA:  Logan Allen (0.00)

Batting Average:  Andrew Vaughn (.354)

Hits:  William Contreras (76)

Home Runs:  Jake Bauers (13)

RBI:  Jake Bauers (46)

Stolen Bases:  David Hamilton (14)

Wins:  Aaron Ashby (9)

Saves:  Trevor Megill (8)

ERA:  Jared Koenig (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (3rd season)

Milwaukee Brewers: Pat Murphy (3rd season)