Cleveland Cavaliers vs Philadelphia 76ers Prediction, Preview and Odds - 01/14/2026

Game Time: 7:00 pm ET, Wednesday, January 14, 2026

Venue:  Xfinity Mobile Arena, Philadelphia, PA

Where to Watch:  ESPN

DraftKings:  Point Spread:  Cavaliers +1.5, 76ers -1.5; Over/Under:  238.5 points

Bet365:  Point Spread:  Cavaliers +1.5, 76ers -1.5; Over/Under:  238.5 points

BetMGM:  Point Spread:  Cavaliers +1.5, 76ers -1.5; Over/Under:  238.5 points

Cleveland Cavaliers:  22-19 (2nd place, Central Division)

Philadelphia 76ers:  22-16 (4th place, Atlantic Division)

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Cleveland Cavaliers:  5-5 last 10

Philadelphia 76ers:  6-4 last 10

The Cavaliers are entering this game with a 22-19 record overall this season and they are 8-9 in their road games this season where they will be in this game. They are entering this game off a loss against the Utah Jazz. Darius Garland led the team in points in that game with 23 while Donovan Mitchell was next on the team with 21 points. Evan Mobley and Darius Garland each led the team in assists in that game with 8 while Evan Mobley led the team in rebounds with 9. They were 44.6% from the field, 41.5% from 3-point range, and 100% from the free throw line with their shots in that game. Their offense is averaging 119.7 PPG and their defense is allowing their opponents to average 117.7 PPG against them. The Cavaliers have an ATS record of 13-28 this season and their O/U record is 19-22.

The 76ers are entering this game with a 22-16 record overall this season and they are 10-9 in their home games this season where they will be in this game. They are entering this game off a win against the Toronto Raptors. Tyrese Maxey led the team in points in that game with 33 while Joel Embiid was next on the team with 27 points. V. J. Edgecombe led the team in assists in that game with 8 while Joel Embiid led the team in rebounds with 8. They were 52.7% from the field, 44.4% from 3-point range, and 91.3% from the free throw line with their shots in that game. Their offense is averaging 117.1 PPG and their defense is allowing their opponents to average 115.2 PPG against them. The 76ers have an ATS record of 23-15 this season and their O/U record is 20-18.

The current betting odds have the 76ers listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The 76ers have looked good in their games this season with their 22-16 record overall which has them right in the top half of the East. They have looked good on their home court too with their 10-9 home record this season. Meanwhile, the Cavaliers have looked good in their games this season with their 22-19 record overall which has them in the top half of the East. They haven't been a great road team though with their 8-9 road record this year. The Cavaliers were one of the best teams in the NBA last season and also had the best record in the East, but they have taken a big step back this season, even though most of the players are the same. They have struggled a lot on the road this season and haven't looked that great lately either. They are 5-5 in their last 10 games and they are off a home loss to the Jazz in their last one. The 76ers haven't looked that great at home this season as they have been a better road team, but they still have a winning record at home and have a lot of good players on the team after drafting well. They have also looked good lately as they are off a win over the Raptors in their last one and they are 6-4 in their last 10 games. The 76ers have figured things out this season while the Cavaliers have taken a step back, and the Cavaliers also have one of the worst records in the NBA against the spread this season. The best way to place a bet here is on the 76ers to cover the spread in this game. 

Cavaliers 76ers Prediction:  Our NBA Pick for Wednesday, January 14, 2026 (7:00 pm ET start time) is 76ers 114 Cavaliers 107.

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Cleveland Cavaliers: 16-10 ATS on the road against Atlantic division opponents. 22-17 ATS on the road versus good offensive teams - scoring 116+ points/game. 36-18 OVER when playing against a marginal winning team (Win Pct. 51% to 60%). 

Philadelphia 76ers: 9-16 ATS at home when the line is +3 to -3. 3-8 ATS off a road win against a division rival. 8-4 OVER off a road win against a division rival. 40-29 OVER versus good offensive teams - scoring 116+ points/game.

Cleveland Cavaliers:  D. Wade (PF) Day To Day - Knee. M. Strus (SF) Out - Foot.

Philadelphia 76ers:  None.

“I think it's the psychology of sports, right? I think they took one on the chin, A tough defeat, and they came in here desperate.” - Kenny Atkinson after his team’s loss against the Jazz in their game on Monday.

"I thought they didn't think I was really going to do it, but I was planning on it there and got a good moment to do it. It was nice to be able to kind of bring him in on his own there." - Nick Nurse after what could be Kyle Lowry’s final NBA game in Toronto.

PG Darius Garland

SG Donovan Mitchell

SF Jaylon Tyson

PF Evan Mobley

C Jarrett Allen

PG Tyrese Maxey

SG VJ Edgecombe

SF Paul George

PF Dominick Barlow

C Joel Embiid

PPG: Donovan Mitchell (29.8)

APG: Darius Garland (6.9)

Reb/G: Evan Mobley (8.6)

PPG: Tyrese Maxey (30.9)

APG: Tyrese Maxey (6.7)

Reb/G: Andre Drummond (8.8)

Coaches:

Cleveland Cavaliers: Kenny Atkinson (2nd season)

Philadelphia 76ers: Nick Nurse (3rd season)