Cincinnati Bengals vs Denver Broncos Prediction, Preview and Odds - 09/29/2025

Game Time: 8:15 pm ET, Monday, September 29, 2025

Venue:  Empower Field at Mile High, Denver, CO

Where to Watch:  ABC

DraftKings:  Point Spread:  Bengals +7.5, Broncos -7.5; Over/Under:  44.5 points

Bet365:  Point Spread:  Bengals +7.5, Broncos -7.5; Over/Under:  44 points

BetMGM:  Point Spread:  Bengals +7.5, Broncos -7.5; Over/Under:  44 points

Cincinnati Bengals:  2-1 (1st place, AFC North)

Denver Broncos:  1-2 (3rd place, AFC North)

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Cincinnati Bengals:  lost their last game on the road against the Minnesota Vikings 48-10.

Denver Broncos:  lost their last game on the road against the Los Angeles Chargers 23-20.

The Bengals are entering this game with a 2-1 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Minnesota Vikings 48-10. Jake Browning was the starting QB and he completed 19/27 passes for 140 passing yards, 1 touchdown, and 2 interceptions. Samaje Perine led the team in rushing yards with 21. Ja'Marr Chase led the receivers with 50 receiving yards on 5 receptions. Jordan Battle led the defense in that game with 5 solo tackles and 2 assisted tackles while Kris Jenkins Jr. led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.

 

 

 

The Broncos are entering this game with a 1-2 record overall and they have a 0-1 record in their divisional games too. They are 1-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Los Angeles Chargers 23-20. Bo Nix was the starting QB and he completed 14/25 passes for 153 passing yards, 1 touchdown, and 0 interceptions. J.K. Dobbins led the team in rushing yards with 83 and 1 TD. Courtland Sutton led the receivers with 118 receiving yards on 6 receptions and 1 TD. Brandon Jones led the defense in that game with 6 solo tackles and 5 assisted tackles while Nik Bonitto led the defense in sacks with 2. Brandon Jones came away with the only interception for them in that one.

The current betting odds have the Broncos listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. The Broncos haven't looked great in their games this season with their 1-2 record overall. They won their season opener and have lost 2 games in a row now, but they lost to the Chargers and the Colts who are both still undefeated after 3 weeks. The Broncos are not as bad as their current record and this is a great situation for them to bounce back at home against a struggling Bengals team plagued by injuries. Meanwhile, the Bengals have a 2-1 record overall and looked great in their first 2 games with a hot start to the season, but now they are off a 48-10 loss on the road against the Vikings and they couldn't do anything in that one. Joe Burrow is going to be out for most of the season now and any hype they had coming into the year feels like it is gone now. The defense has looked better this year, but they still don't have a good defense so this Broncos offense will have a much better game than they did the last 2 weeks against better defenses. The Broncos also have one of the best defenses in the NFL so this struggling Bengals offense isn't going to do much on the road here. The best way to place a bet here is on the Broncos to cover the spread in this game. 

Bengals Broncos Prediction:  Our NFL Pick for Monday, September 29, 2025 (8:15 pm ET start time) is Broncos 31 Bengals 6.

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Cincinnati Bengals: 4-7 ATS as an underdog. 2-6 ATS off a road loss. 3-7 ATS in the first month of the season. 23-14 OVER in all games. 7-2 OVER as a road underdog. 17-8 OVER in all games where the total is between 42.5 and 49 points.

Denver Broncos: 5-1 ATS after 2 or more consecutive losses. 6-3 ATS vs. bad defensive teams who give up 24 or more points/game. 6-3 ATS versus poor defensive teams - allowing 350 yards/game or more. 9-1 OVER vs. bad defensive teams who give up 24 or more points/game. 5-0 OVER vs. poor teams - outscored by 6+ points per game on the season.

Cincinnati Bengals:  N. Fant (TE) Injured - Concussion. S. Perine (RB) Injured - Finger. D. Risner (OG) Injured - Calf. S. Stewart (DL) Injured - Ankle. C. Taylor-Britt (CB) Injured - Hamstring.

Denver Broncos:  A. Singleton (LB) Injured - Thumb. E. Engram (TE) Injured - Back. J. Franklin-Myers (DL) Injured - Hip. N. Adkins (TE) Injured - Foot. N. Bonitto (LB) Injured - Wrist.

“This is a collective effort. I didn’t see the line have one turnover today, OK? I saw a bunch of other guys have five. So very clearly this is on the entire team.” - Zac Taylor after his team’s loss against the Vikings in their last game. 

“This was a hard-fought, close game. We got to get better fast. If we do, this'll be all right.” - Sean Payton after his team’s loss against the LA Chargers in their last game.

WR Chase, Ja'Marr

WR Higgins, Tee

WR Iosivas, Andrei

TE Sample, Drew

QB Browning, Jake

RB Brown, Chase

WR Sutton, Courtland

WR Mims Jr., Marvin

WR Franklin, Troy

TE Trautman, Adam

QB Nix, Bo

RB Dobbins, J.K.

FB Prentice, Adam

Passing: Jake Browning (381)

Rushing: Chase Brown (93)

Receiving: Ja'Marr Chase (241)

Touchdowns: Chase Brown (1)

Passing: Bo Nix (535)

Rushing: J.K. Dobbins (222)

Receiving: Courtland Sutton (185)

Touchdowns: J.K. Dobbins (3)

Coaches:

Cincinnati Bengals: Zac Taylor (7th season)

Denver Broncos: Sean Payton (3rd season)