Chicago White Sox vs Texas Rangers Prediction, Preview and Odds - 07/22/2026

Game Time: 8:05 pm ET, Wednesday, July 22, 2026

Venue:  Globe Life Field, Arlington, TX

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox -105, Rangers -115; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  White Sox -105, Rangers -115; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  White Sox -105, Rangers -115; Over/Under:  8.5 runs

Chicago White Sox:  53-46 (1st place, AL Central)

Texas Rangers:  50-50 (2nd place, AL West)

Do not miss out on our expert handicapper analysis! Vegas Writer is on a HOT STREAK in MLB on a 72-56-2 MLB RUN for +$13,960 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Chicago White Sox:  6-4 last 10

Texas Rangers:  5-5 last 10

The White Sox are entering this series off a win and won their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 53-46 record overall and have a road record of 22-29. This is the series finale of a 3-game series with the Rangers on Wednesday with the 2nd game still to be played on Tuesday. The White Sox won the series opener on Monday. Their offense ranks 12th in the MLB with a .732 OPS. Rookie pitcher Noah Schultz is their starting pitcher on Tuesday while Anthony Kay is making his start in this game on Wednesday. He is 6-4 with a 4.24 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 1 HR, and 3 BB with 5 SO on 2 hits through 4 IP against the Toronto Blue Jays.

The Rangers are entering this series off a loss and lost their 3-game series against the Atlanta Braves 2-1 in their last series. They enter this game with a 50-50 record overall and have a home record of 24-23. This is the 3rd game of a 3-game series with the White Sox on Wednesday with the 2nd game of this series still to be played on Tuesday. The Rangers lost the 1st game of this series on Monday. Their offense ranks 16th in the MLB with a .719 OPS. Kumar Rocker is their starting pitcher on Tuesday while Cal Quantrill is making his start in this game on Wednesday. He is 3-2 with a 3.93 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 6 earned runs, 2 homers, and 1 walk with 3 strikeouts on 11 hits through 4 innings pitched against the Atlanta Braves.

The current betting odds have the White Sox listed as a slight underdog in this game according to Draftkings Sportsbook. The White Sox have looked good in their games this season with their 53-46 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 22-29 road record this year. Meanwhile, the Rangers have looked good in their games this season with their 50-50 record overall which has them right near the top of the AL West. They have looked better in their own ballpark too with their 24-23 home record this season. The Rangers haven't looked great lately though, now 5-5 in their last 10 games, while the White Sox are 6-4 in their last 10 games, getting hot again with an offense in the top half of the league. They are going with Kay in this one and he hasn't looked great this season. He is 6-4 with a 4.24 ERA and has been giving up quite a few runs this year, but lately he has looked a lot better. The team has still lost 3 of their last 4 games with him starting, but he only gave up 2 earned runs in his last start and the White Sox do have a really good offense to bail him out if he gets into trouble. The Rangers are going with Quantrill in this one and he hasn't looked bad this season. He is 3-2 with a 3.93 ERA and hasn't been giving up many runs in his starts, but that is starting to change now. He is coming off a terrible start in which he gave up 6 earned runs and the team has lost 2 of their last 3 games with him starting too. The White Sox can take advantage of the way he has been pitching lately, so look for the White Sox to take this game with the stronger offense leading the way. The best way to place a bet here is on the White Sox to win this game. 

White Sox Rangers Prediction:  Our MLB Pick for Wednesday, July 22, 2026 (8:05 pm ET start time) is White Sox 9 Rangers 4.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Chicago White Sox Texas Rangers prediction, be sure to drop by every day for our daily MLB projections and previews.

Chicago White Sox: 13-6 (+9.4 units) on the moneyline against AL West opponents. 53-46 (+16.8 units) on the moneyline in all games. 38-31 (+14.2 units) on the moneyline against right-handed starters. 21-12 OVER as a road underdog of +100 to +150.

Texas Rangers: 209-215 (-21.9 units) on the moneyline in all games. 47-57 (-13.1 units) on the moneyline against left-handed starters. 94-117 (-19.9 units) on the moneyline when playing against a team with a winning record. 12-4 OVER vs. a starting pitcher whose lasts less than 5 innings per start.

Chicago White Sox:  K. Teel (C) Day To Day - Ankle. C. Montgomery (SS) Day To Day - Leg. E. Pereira (RF) Seven Day IL - Concussion. T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Texas Rangers:  C. Martin (RP) Fifteen Day IL - Shoulder. C. Seager (SS) Ten Day IL - Back. C. Freeman (3B) Ten Day IL - Disc. J. Leiter (SP) Fifteen Day IL - Ankle. M. Helman (CF) Sixty Day IL - Hand. J. Beeks (RP) Ten Day IL - Back. D. Jansen (C) Ten Day IL - Forearm. R. Garcia (RP) Sixty Day IL - Shoulder. C. Baumler (RP) Sixty Day IL - Ribs. C. Bradford (RP) Sixty Day IL - Elbow. J. Montgomery (SP) Sixty Day IL - Elbow.

“It's really tough, as much passion as he has for the game, as hard as he works. You feel bad for any of these guys when they go down, but Kyle, having to deal with so many things here and so many setbacks is really tough.” - Will Venable on the injury to Kyle Teel after his team’s win against the Rangers in their game on Monday. 

“You show up the same way every day, and that's to win baseball games. We played good going into the break and haven't played good right after the break. So we gotta lock it in and play good baseball. We gotta do it for the rest of the year. It starts with the starting pitching, and we got to do a better job as a group.” - Jacob deGrom after their loss against the White Sox in their game on Monday.

Sam Antonacci (L) LF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Colson Montgomery (L) SS

Andrew Benintendi (L) DH

Kyle Teel (L) C

Braden Montgomery (S) RF

Tristan Peters (L) CF

Chase Meidroth (R) 2B

Joc Pederson (L) DH

Wyatt Langford (R) LF

Josh Jung (R) 3B

Brandon Nimmo (L) RF

Jake Burger (R) 1B

Ezequiel Duran (R) SS

Evan Carter (L) CF

Elias Díaz (R) C

Nicky Lopez (L) 2B

Batting Average:  Tristan Peters (.292)

Hits:  Chase Meidroth (97)

Home Runs:  Colson Montgomery (24)

RBI:  Miguel Vargas (61)

Stolen Bases:  Luisangel Acuña (15)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Batting Average:  Nicky Lopez (.323)

Hits:  Josh Jung (103)

Home Runs:  Jake Burger (17)

RBI:  Jake Burger (60)

Stolen Bases:  Evan Carter (11)

Wins:  Nathan Eovaldi (9)

Saves:  Jacob Latz (19)

ERA:  Jacob Latz (1.57)

Managers:

Chicago White Sox: Will Venable (2nd season)

Texas Rangers: Skip Schumaker (1st season)