Chicago White Sox vs Philadelphia Phillies Prediction, Preview and Odds - 06/05/2026

Game Time: 6:40 pm ET, Friday, June 5, 2026

Venue:  Citizens Bank Park, Philadelphia, PA

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox +150, Phillies -180; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  White Sox +150, Phillies -180; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  White Sox +150, Phillies -180; Over/Under:  8.5 runs

Chicago White Sox:  33-29 (2nd place, AL Central)

Philadelphia Phillies:  32-29 (2nd place, NL East)

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Chicago White Sox:  7-3 last 10

Philadelphia Phillies:  7-3 last 10

The White Sox are entering this series off a win and lost their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 33-29 record overall and have a road record of 13-18. This is the series opener of a 3-game series with the Phillies on Friday and they have Thursday off as a day of rest. Their offense ranks 5th in the MLB with a .735 OPS. Erick Fedde was their starting pitcher on Wednesday while Anthony Kay is making his start in this game on Friday. He is 5-1 with a 3.77 ERA this season. His team won their last 5 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 1 HR, and 1 BB with 3 SO on 6 hits through 5 IP against the Detroit Tigers.

The Phillies lost their 3-game series against the Los Angeles Dodgers 2-1. They enter this game with a 32-29 record overall and have a home record of 16-16. This is the 1st game of a 3-game series with the White Sox on Friday with the series finale of their series against the San Diego Padres still to be played on Thursday. The Phillies won the 1st game of that series on Tuesday and the 2nd game on Wednesday. Their offense ranks 28th in the MLB with a .677 OPS. Zack Wheeler is their starting pitcher on Thursday while Jesús Luzardo is making his start in this game on Friday. He is 4-4 with a 4.30 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 2 walks with 6 strikeouts on 7 hits through 5.1 innings pitched against the Los Angeles Dodgers.

The current betting odds have the White Sox listed as an underdog in this game according to Draftkings Sportsbook. The White Sox have looked good in their games this season with their 33-29 record overall which has them right near the top of the AL Central. They haven't been a great road team though with their 13-18 road record this year. Meanwhile, the Phillies have looked good in their games this season with their 32-29 record overall which has them right near the top of the NL East. They haven't looked great in their own ballpark though with their 16-16 home record this season. The Phillies are 7-3 in their last 10 games and they have looked a lot better lately after a terrible start to the season, but their offense still hasn't looked that great. The White Sox have also been rolling lately as they are 7-3 in their last 10 games and they have been putting up a ton of runs with one of the best offenses in MLB at the moment. Kay is on the mound for the White Sox in this one and he has looked good this season. He is 5-1 with a 3.77 ERA and the team has been having a ton of success with him lately. They have won 5 games in a row now with him starting and he hasn't been giving up as many runs lately either, coming off a great start in which he only gave up 1 earned run. The Phillies are going with Luzardo in this one and he hasn't looked great this year. He is 4-4 with a 4.30 ERA and hasn't really been one of the studs for the Phillies. He only gave up 2 earned runs in his last start and the team has won 2 of their last 3 games with him starting too, but that hasn't been a common theme for him and he is going to give up more runs here with the White Sox hitting well. The White Sox are a big underdog here, but they are going to have a solid starter in this one along with the better offense too, so look for the red hot White Sox to steal this series opener. The best way to place a bet here is on the White Sox to win this game. 

White Sox Phillies Prediction:  Our MLB Pick for Friday, June 5, 2026 (6:40 pm ET start time) is White Sox 8 Phillies 4.

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Chicago White Sox: 134-252 (-60.9 units) on the moneyline in all games. 58-135 (-42.5 units) on the moneyline in road games. 114-238 (-63.6 units) on the moneyline as an underdog of +100 or higher. 4-0 UNDER after shutting out their opponent.

Philadelphia Phillies: 226-168 (+5.7 units) on the moneyline in all games. 127-72 (+19.1 units) on the moneyline in home games. 186-112 (+15.4 units) on the moneyline as a favorite of -110 or higher. 21-12 UNDER when playing against a team with a winning record.

Chicago White Sox:  J. Leasure (RP) Sixty Day IL - Flexor. M. Murakami (1B) Ten Day IL - Hamstring. N. Schultz (SP) Fifteen Day IL - Knee. J. Hicks (RP) Fifteen Day IL - Lat. K. Teel (C) Sixty Day IL - Hamstring. A. Hays (LF) Ten Day IL - Calf. T. Murray (LF) Sixty Day IL - Shoulder. E. Pereira (RF) Ten Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Philadelphia Phillies:  K. Backhus (RP) Fifteen Day IL - Elbow.

“He did a good job setting the tone for the group. A guy up there who’s been doing it really since he's got up here. And the guys followed his lead behind him. We had quality at-bats up and down the lineup, contributions from everywhere.” - Will Venable on Sam Antonacci after his team’s win against the Twins in their game on Wednesday. 

“You don’t get to see things like this very often. It’s one of those things that’s not happened very often. It’s hard to categorize it. I don’t know if I’ve seen anything that’s really been better than this.” - Don Mattingly on Cristopher Sanchez after his team’s win against the Padres in their game on Wednesday. 

Sam Antonacci (L) LF

Miguel Vargas (R) 3B

Andrew Benintendi (L) DH

Colson Montgomery (L) SS

Chase Meidroth (R) 2B

Jacob Gonzalez (L) 1B

Tristan Peters (L) CF

Drew Romo (S) C

Rikuu Nishida (L) RF

Kyle Schwarber (Z) DH

Trea Turner (D) SS

Bryce Harper (Z) 1B

Brandon Marsh (Z) LF

Alec Bohm (D) 3B

Bryson Stott (Z) 2B

J.T. Realmuto (D) C

Adolis García (D) RF

Justin Crawford (Z) CF

Batting Average:  Sam Antonacci (.291)

Hits:  Chase Meidroth (61)

Home Runs:  Munetaka Murakami (20)

RBI:  Munetaka Murakami (41)

Stolen Bases:  Luisangel Acuña (11)

Wins:  Davis Martin (8)

Saves:  Seranthony Domínguez (11)

ERA:  Duncan Davitt (0.00)

Batting Average:  Brandon Marsh (.335)

Hits:  Brandon Marsh (66)

Home Runs:  Kyle Schwarber (23)

RBI:  Kyle Schwarber (40)

Stolen Bases:  Trea Turner (11)

Wins:  Cristopher Sánchez (7)

Saves:  Jhoan Duran (14)

ERA:  Jhoan Duran (1.37)

Managers:

Chicago White Sox: Will Venable (2nd season)

Philadelphia Phillies: Don Mattingly (Interim)