Chicago White Sox vs New York Yankees Prediction, Preview and Odds - 06/17/2026

Game Time: 7:05 pm ET, Wednesday, June 17, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV, Prime Video

DraftKings:  Moneyline odds:  White Sox +150, Yankees -185; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  White Sox +155, Yankees -185; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  White Sox +155, Yankees -190; Over/Under:  8.5 runs

Chicago White Sox:  38-32 (1st place, AL Central)

New York Yankees:  43-27 (1st place, AL East)

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Chicago White Sox:  6-4 last 10

New York Yankees:  7-3 last 10

The White Sox are entering this series off a win and won their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 38-32 record overall and have a road record of 14-20. This is the 2nd game of a 3-game series with the Yankees on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 6th in the MLB with a .737 OPS. Davis Martin is their starting pitcher on Tuesday while Anthony Kay is making his start in this game on Wednesday. He is 6-1 with a 4.34 ERA this season. His team won 6 of their last 7 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 1 BB with 7 SO on 4 hits through 5 IP against the Los Angeles Dodgers.

The Yankees are entering this series off a win and won their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 43-27 record overall and have a home record of 19-12. This is the 2nd game of a 3-game series with the White Sox on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 2nd in the MLB with a .763 OPS. Gerrit Cole is their starting pitcher on Tuesday while Carlos Rodón is making his start in this game on Wednesday. He is 2-2 with a 3.19 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 1 homer, and 3 walks with 7 strikeouts on 4 hits through 6 innings pitched against the Cleveland Guardians.

The current betting odds have the Yankees listed as a big favorite in this game according to Draftkings Sportsbook. The Yankees have looked great in their games this season with their 43-27 record overall which has them right at the top of the AL East with one of the best records in MLB. They have looked great in their own ballpark too with their 19-12 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 38-32 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 14-20 road record this year. The White Sox are 6-4 in their last 10 games and they have taken over the lead of their division, but the Yankees have done the same in their own division as they have been getting hot lately too, now 7-3 in their last 10 games. Kay is on the mound for the White Sox in this one and he has looked good this season. He is 6-1 with a 4.34 ERA and his team has been having a ton of success with him lately, but he has still been giving up quite a few runs all season. They have won 6 of their last 7 games with him starting and he only gave up 2 earned runs in his last start too, but that hasn't been a common theme for him this season and the Yankees do have one of the best offenses in MLB. Rodon is on the mound for the Yankees in this one and he has looked great this season. He is 2-2 with a 3.19 ERA and he hasn't been giving up many runs lately. He gave up 3 earned runs in his last start, but that hasn't been a common theme for him and his team has won 3 games in a row now with him starting. The White Sox do have a great offense this season too, but the Yankees still have the better lineup along with the better bullpen to help out. Look for the Yankees to take advantage of this pitching matchup and continue rolling at home. The best way to place a bet here is on the Yankees to win this game. 

White Sox Yankees Prediction:  Our MLB Pick for Wednesday, June 17, 2026 (7:05 pm ET start time) is Yankees 5 White Sox 2.

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Chicago White Sox: 24-49 (-7.4 units) on the moneyline against AL East opponents. 139-255 (-56.9 units) on the moneyline in all games. 59-137 (-43.2 units) on the moneyline in road games. 21-12 OVER in road games.

New York Yankees: 62-21 (+29.9 units) on the moneyline against AL Central opponents. 58-29 (+9.3 units) on the moneyline as a home favorite of -150 to -200. 174-113 (+5.5 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 6-3 OVER vs. a starting pitcher whose lasts less than 5 innings per start.

Chicago White Sox:  T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. M. Murakami (1B) Ten Day IL - Hamstring. J. Leasure (RP) Sixty Day IL - Flexor. N. Schultz (SP) Fifteen Day IL - Knee. J. Hicks (RP) Fifteen Day IL - Lat. K. Teel (C) Sixty Day IL - Hamstring. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

New York Yankees:  T. Grisham (CF) Ten Day IL - Hamstring. A. Wells (C) Ten Day IL - Cervical Headaches. A. Judge (RF) Ten Day IL - Rib. M. Fried (SP) Fifteen Day IL - Elbow. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

“It's good just for the team. Obviously a big series, it's been a tough stretch. Just keeps the confidence growing.” - Erick Fedde after their win against the LA Dodgers in their game on Sunday. 

“It feels good to shake hands and be celebrating a win in here. Obviously, that was very difficult for us in this building last year. It is a new year, and you’ve got to keep going all the time, but what a good finish to an outstanding [5-1] road trip.” - Aaron Boone after his team’s win against the Blue Jays in their game on Sunday. 

Sam Antonacci (L) LF

Miguel Vargas (R) 3B

Andrew Benintendi (L) DH

Colson Montgomery (L) SS

Braden Montgomery (S) RF

Chase Meidroth (R) 2B

Jacob Gonzalez (L) 1B

Tristan Peters (L) CF

Drew Romo (S) C

Paul Goldschmidt (R) 1B

Ben Rice (L) DH

Jasson Domínguez (S) RF

Cody Bellinger (L) CF

Amed Rosario (R) 3B

José Caballero (R) 2B

Max Schuemann (R) LF

Anthony Volpe (R) SS

Ali Sánchez (R) C

Batting Average:  Randal Grichuk (.316)

Hits:  Chase Meidroth (71)

Home Runs:  Munetaka Murakami (20)

RBI:  Miguel Vargas (44)

Stolen Bases:  Luisangel Acuña (12)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Batting Average:  Paul Goldschmidt (.295)

Hits:  Ben Rice (70)

Home Runs:  Ben Rice (19)

RBI:  Ben Rice (47)

Stolen Bases:  Jazz Chisholm (20)

Wins:  Cam Schlittler (7)

Saves:  David Bednar (14)

ERA:  Yovanny Cruz (0.00)

Managers:

Chicago White Sox: Will Venable (2nd season)

New York Yankees: Aaron Boone (9th season)