Chicago White Sox vs New York Yankees Prediction, Preview and Odds - 06/16/2026

Game Time: 7:05 pm ET, Tuesday, June 16, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox +119, Yankees -143; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  White Sox +120, Yankees -140; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  White Sox +120, Yankees -140; Over/Under:  7.5 runs

Chicago White Sox:  38-32 (1st place, AL Central)

New York Yankees:  43-27 (1st place, AL East)

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Chicago White Sox:  6-4 last 10

New York Yankees:  7-3 last 10

The White Sox are entering this series off a win and won their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 38-32 record overall and have a road record of 14-20. This is the series opener of a 3-game series with the Yankees on Tuesday and they have Monday off as a day of rest. Their offense ranks 6th in the MLB with a .737 OPS. Bryan Hudson was their starting pitcher on Sunday while Davis Martin is making his start in this game on Tuesday. He is 9-2 with a 2.41 ERA this season. His team won 9 of their last 10 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 0 BB with 6 SO on 6 hits through 6 IP against the Atlanta Braves.

The Yankees are entering this series off a win and won their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 43-27 record overall and have a home record of 19-12. This is the 1st game of a 3-game series with the White Sox on Tuesday and they have Monday off as a day of rest. Their offense ranks 2nd in the MLB with a .763 OPS. Will Warren was their starting pitcher on Sunday while Gerrit Cole is making his start in this game on Tuesday. He is 1-1 with a 2.45 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 2 walks with 4 strikeouts on 5 hits through 4 innings pitched against the Cleveland Guardians.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked great in their games this season with their 43-27 record overall which has them right at the top of the AL East with one of the best records in MLB. They have looked great in their own ballpark too with their 19-12 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 38-32 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 14-20 road record this year. The White Sox are 6-4 in their last 10 games and just beat the Dodgers at home in their last series, but they have looked like a different team in road games this season. The Yankees have also been rolling lately and they are now 7-3 in their last 10 games after winning their series against the Blue Jays. Cole is on the mound for the Yankees in this one and he has looked great this season. He is 1-1 with a 2.45 ERA and he hasn't been giving up many runs since coming back from his injury. He is coming off another great start in which he gave up 2 earned runs, something that has been a common theme for him, and his team has won 2 of their last 3 games with him starting. The White Sox are going with Martin in this one and he has also looked great this season. He is 9-2 with a 2.41 ERA and his team has been having a ton of success with him lately. They have won 9 of their last 10 games with him starting and he is coming off another great start in which he gave up no runs, but he is due for a let down after that great start against the Braves. Both of these teams have great offenses this year, but Cole has still been the more reliable starter over the years and the Yankees have a big edge at home with the way the White Sox have looked in road games. Look for the Yankees to edge this one out at home. The best way to place a bet here is on the Yankees to win this game. 

White Sox Yankees Prediction:  Our MLB Pick for Tuesday, June 16, 2026 (7:05 pm ET start time) is Yankees 3 White Sox 1.

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Chicago White Sox: 24-49 (-7.4 units) on the moneyline against AL East opponents. 139-255 (-56.9 units) on the moneyline in all games. 59-137 (-43.2 units) on the moneyline in road games. 21-12 OVER in road games.

New York Yankees: 62-21 (+29.9 units) on the moneyline against AL Central opponents. 184-124 (+7.2 units) on the moneyline against right-handed starters. 91-61 (+7.1 units) on the moneyline vs. an AL starting pitcher whose WHIP is 1.300 or better. 16-9 OVER after 3 or more consecutive road games.

Chicago White Sox:  T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. M. Murakami (1B) Ten Day IL - Hamstring. J. Leasure (RP) Sixty Day IL - Flexor. N. Schultz (SP) Fifteen Day IL - Knee. J. Hicks (RP) Fifteen Day IL - Lat. K. Teel (C) Sixty Day IL - Hamstring. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

New York Yankees:  T. Grisham (CF) Ten Day IL - Hamstring. A. Wells (C) Ten Day IL - Cervical Headaches. A. Judge (RF) Ten Day IL - Rib. M. Fried (SP) Fifteen Day IL - Elbow. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

“It's good just for the team. Obviously a big series, it's been a tough stretch. Just keeps the confidence growing.” - Erick Fedde after their win against the LA Dodgers in their game on Sunday. 

“It feels good to shake hands and be celebrating a win in here. Obviously, that was very difficult for us in this building last year. It is a new year, and you’ve got to keep going all the time, but what a good finish to an outstanding [5-1] road trip.” - Aaron Boone after his team’s win against the Blue Jays in their game on Sunday. 

Sam Antonacci (L) LF

Miguel Vargas (R) 3B

Andrew Benintendi (L) DH

Colson Montgomery (L) SS

Braden Montgomery (S) RF

Chase Meidroth (R) 2B

Jacob Gonzalez (L) 1B

Tristan Peters (L) CF

Drew Romo (S) C

Paul Goldschmidt (R) 1B

Ben Rice (L) DH

Jasson Domínguez (S) RF

Cody Bellinger (L) CF

Amed Rosario (R) 3B

José Caballero (R) 2B

Max Schuemann (R) LF

Anthony Volpe (R) SS

Ali Sánchez (R) C

Batting Average:  Randal Grichuk (.316)

Hits:  Chase Meidroth (71)

Home Runs:  Munetaka Murakami (20)

RBI:  Miguel Vargas (44)

Stolen Bases:  Luisangel Acuña (12)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Batting Average:  Paul Goldschmidt (.295)

Hits:  Ben Rice (70)

Home Runs:  Ben Rice (19)

RBI:  Ben Rice (47)

Stolen Bases:  Jazz Chisholm (20)

Wins:  Cam Schlittler (7)

Saves:  David Bednar (14)

ERA:  Yovanny Cruz (0.00)

Managers:

Chicago White Sox: Will Venable (2nd season)

New York Yankees: Aaron Boone (9th season)