Chicago White Sox vs Minnesota Twins Prediction, Preview and Odds - 08/29/2026

Game Time: 2:10 pm ET, Saturday, August 29, 2026

Venue:  Target Field, Minneapolis, MN

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox +105, Twins -125; Over/Under:  9.5 runs

Bet365:  Moneyline odds:  White Sox +105, Twins -125; Over/Under:  9.5 runs

BetMGM:  Moneyline odds:  White Sox +105, Twins -125; Over/Under:  9.5 runs

Chicago White Sox:  70-63 (1st place, AL Central)

Minnesota Twins:  64-70 (3rd place, AL Central)

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Chicago White Sox:  5-5 last 10

Minnesota Twins:  4-6 last 10

The White Sox are entering this series off a win and won their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 70-63 record overall and have a road record of 29-36. This is the 2nd game of a 3-game series with the Twins on Saturday with the series opener still to be played on Friday. Their offense ranks 7th in the MLB with a .731 OPS. Luis Castillo is their starting pitcher on Friday while Erick Fedde is making his start in this game on Saturday. He is 6-8 with a 4.18 ERA this season. His team lost 5 of their last 6 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 1 BB with 2 SO on 3 hits through 4 IP against the New York Mets.

The Twins are entering this series off a loss and lost their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 64-70 record overall and have a home record of 35-31. This is the 2nd game of a 3-game series with the White Sox on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 12th in the MLB with a .724 OPS. Dean Kremer is their starting pitcher on Friday while Bailey Ober is making his start in this game on Saturday. He is 7-4 with a 4.49 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 3 walks with 3 strikeouts on 4 hits through 5 innings pitched against the San Diego Padres.

The current betting odds have the Twins listed as a slight favorite in this game according to Draftkings Sportsbook. The Twins haven't looked great in their games this season with their 64-70 record overall which has them right in the middle of the AL Central. They have looked a lot better in their own ballpark though with their 35-31 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 70-63 record overall which has them right at the top of the AL Central. They haven't been a great road team though with their 29-36 road record this year. The Twins are 4-6 in their last 10 games, but the White Sox are 5-5 in their last 10 games and haven't looked great lately either. They have also had a lot more trouble in their road games this year while the Twins have been better at home, and the Twins need this series a lot more to get back into the playoff race. The White Sox are going wih Fedde in this one and he hasn't looked great this season. He is 6-8 with a 4.18 ERA and he has been giving up quite a few runs this year. He gave up no runs in his last appearance, but that hasn't been a common theme for him this year and the team has also had a lot of trouble with him lately, losing 5 of their last 6 games that he pitched in. The Twins are going with Ober in this one and he hasn't looked great this season either. He is 7-4 with a 4.49 ERA, but he has looked a lot better lately. The team has still lost 2 of their last 3 games with him starting, but he only gave up 1 earned run in his last start. He has also looked a lot better in his home starts this season and the Twins don't have a bad offense either. Look for the Twins to take advantage of this pitching matchup with Ober pitching a lot better at home this season. The best way to place a bet here is on the Twins to win this game. 

White Sox Twins Prediction:  Our MLB Pick for Saturday, August 29, 2026 (2:10 pm ET start time) is Twins 4 White Sox 3.

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Chicago White Sox: 70-63 (+17.1 units) on the moneyline in all games. 23-13 (+12.3 units) on the moneyline against division opponents. 50-41 (+17.2 units) on the moneyline against right-handed starters. 27-16 OVER as a road underdog of +100 to +150.

Minnesota Twins: 216-242 (-49.1 units) on the moneyline in all games. 116-112 (-23.9 units) on the moneyline in home games. 68-73 (-12.1 units) on the moneyline against division opponents. 42-23 OVER when the money line is +125 to -125.

Chicago White Sox:  H. Brazoban (RP) Fifteen Day IL - Lat. D. Martin (SP) Fifteen Day IL - Finger. C. Murphy (RP) Fifteen Day IL - Flexor. J. Bart (C) Ten Day IL - Hand. K. Teel (C) Ten Day IL - Ankle. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Minnesota Twins:  B. Buxton (CF) Day To Day - Back. A. Martin (RF) Ten Day IL - Hamstring. J. Ryan (SP) Fifteen Day IL - Glute. M. Paredes (SP) Sixty Day IL - Oblique. C. Sands (RP) Sixty Day IL - Elbow. A. Banda (RP) Sixty Day IL - Lat. M. Abel (SP) Sixty Day IL - Elbow. D. Festa (SP) Sixty Day IL - Shoulder. P. Lopez (SP) Sixty Day IL - Elbow.

“It's amazing. I don't know what words there are for what he's doing. Really, really special. Really cool to watch. And obviously big for us today, what he did and the rest of the offense.” - Will Venable after his team’s win against the Rangers in their game on Wednesday. 

“We need to continue to add on. It seems like during this road trip, we did not have the ability to add on.” - Derek Shelton after his team’s loss against the A’s in their game on Wednesday.

Miguel Vargas (R) 3B

Munetaka Murakami (L) 1B

Randal Grichuk (R) DH

Chase Meidroth (R) 2B

Braden Montgomery (S) RF

Brenton Doyle (R) CF

Jake Rogers (R) C

Tristan Peters (L) LF

Luisangel Acuña (R) SS

Luke Keaschall (R) CF

Brooks Lee (S) 3B

Josh Bell (S) DH

Ryan Jeffers (R) C

Kody Clemens (L) 2B

Royce Lewis (R) 1B

Trevor Larnach (L) LF

Kaelen Culpepper (R) SS

Alan Roden (L) RF

Batting Average:  Randal Grichuk (.293)

Hits:  Chase Meidroth (130)

Home Runs:  Munetaka Murakami (29)

RBI:  Miguel Vargas (76)

Stolen Bases:  Luisangel Acuña (16)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Hagen Smith (0.93)

Batting Average:  Gabriel Gonzalez (.500)

Hits:  Josh Bell (119)

Home Runs:  Byron Buxton (25)

RBI:  Josh Bell (80)

Stolen Bases:  Luke Keaschall (15)

Wins:  Taj Bradley (9)

Saves:  Yoendrys Gómez (19)

ERA:  Jack Anderson (0.00)

Managers:

Chicago White Sox: Will Venable (2nd season)

Minnesota Twins: Derek Shelton (1st season)