Chicago White Sox vs Houston Astros Prediction, Preview and Odds - 09/03/2026

Game Time: 2:10 pm ET, Thursday, September 3, 2026

Venue:  Daikin Park, Houston, TX

Where to Watch:  ESPN Unlimited, MLB TV

DraftKings:  Moneyline odds:  White Sox +134, Astros -162; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  White Sox +135, Astros -165; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  White Sox +135, Astros -165; Over/Under:  8.5 runs

Chicago White Sox:  73-65 (1st place, AL Central)

Houston Astros:  70-69 (1st place, AL West)

Do not miss out on our expert handicapper analysis! Hollywood Sports is on a HOT STREAK in MLB on a 5-0 MLB RUN for +$5,000 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Chicago White Sox:  6-4 last 10

Houston Astros:  5-5 last 10

The White Sox are entering this series off a loss and won their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 73-65 record overall and have a road record of 32-38. This is the series finale of a 4-game series with the Astros on Thursday with the 3rd game still to be played on Wednesday. The White Sox lost the series opener on Monday and won the 2nd game on Tuesday. Their offense ranks 10th in the MLB with a .727 OPS. Davis Martin is their starting pitcher on Wednesday while Luis Castillo is making his start in this game on Thursday. He is 4-10 with a 5.31 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 2 HR, and 1 BB with 1 SO on 8 hits through 4 IP against the Minnesota Twins.

The Astros are entering this series off a win and won their 3-game series against the New York Mets 2-1 in their last series. They enter this game with a 70-69 record overall and have a home record of 34-36. This is the 4th game of a 4-game series with the White Sox on Thursday with the 3rd game of this series still to be played on Wednesday. The Astros won the 1st game of this series on Monday and lost the 2nd game on Tuesday. Their offense ranks 11th in the MLB with a .724 OPS. Hayden Wesneski is their starting pitcher on Wednesday while Hunter Brown is making his start in this game on Thursday. He is 4-3 with a 3.33 ERA this season. His team lost 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 10 strikeouts on 5 hits through 6.2 innings pitched against the New York Mets.

The current betting odds have the Astros listed as a favorite in this game according to Draftkings Sportsbook. The Astros have looked good in their games this season with their 70-69 record overall which has them right at the top of the AL West. They haven't looked great in their own ballpark though with their 34-36 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 73-65 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 32-38 road record this year. The White Sox are 6-4 in their last 10 games and they have looked good lately while the Astros are 5-5 in their last 10 games, but the Astros are desperately trying to stay in the lead of their division and they are going to have the better pitching matchup here. The Astros are going with Brown in this one and he has looked good this season. He is 4-3 with a 3.33 ERA and he hasn't been giving up many runs in his starts. His team hasn't had a ton of success with him lately, losing 4 of their last 5 games with him starting, but he is coming off a great start in which he gave up 1 earned run and that has been a common theme for him. The White Sox are going with Castillo in this one and he hasn't looked good this season. He is 4-10 with a 5.31 ERA and he has been giving up a ton of runs all year. He is coming off another bad start giving up 4 earned runs which has been a common theme for him and the team hasn't been having success with him either, losing 2 of their last 3 games with him starting. The Astros are still looking to lock up their division in a really tight race and they haven't been giving up a ton of runs in their games lately, this is a pitching matchup that they can definitely take advantage of at home. The best way to place a bet here is on the Astros to win this game. 

White Sox Astros Prediction:  Our MLB Pick for Thursday, September 3, 2026 (2:10 pm ET start time) is Astros 7 White Sox 3.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Chicago White Sox Houston Astros prediction, be sure to drop by every day for our daily MLB projections and previews.

Chicago White Sox: 174-288 (-52.8 units) on the moneyline in all games. 77-155 (-39.5 units) on the moneyline in road games. 128-213 (-37.4 units) on the moneyline against right-handed starters. 29-17 OVER as a road underdog of +100 to +150.

Houston Astros: 138-109 (+5.6 units) on the moneyline vs. an AL team with a slugging percentage .410 or worse on the season. 112-102 (+9.4 units) on the moneyline when playing against a team with a winning record. 162-139 (+14.2 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 32-18 OVER when playing against a team with a winning record.

Chicago White Sox:  H. Brazoban (RP) Fifteen Day IL - Lat. D. Martin (SP) Fifteen Day IL - Finger. C. Murphy (RP) Fifteen Day IL - Flexor. J. Bart (C) Ten Day IL - Hand. K. Teel (C) Ten Day IL - Ankle. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Houston Astros:  B. Matthews (CF) Sixty Day IL - Knee. M. Burrows (SP) Fifteen Day IL - Elbow. C. Correa (SS) Sixty Day IL - Ankle. B. Walter (RP) Sixty Day IL - Elbow.

“There was still some frustration from [Burke after] the first couple, just not finding his groove. But he was able to get on track there in the third or fourth, and pitched really nicely.” - Will Venable after his team’s win against the Astros in their game on Tuesday. 

“I'm going to go to Florida now and get more intense, and we're gonna progress to running bases and all that. And then from there, we go. This is a real final test.” - Carlos Correa on rehab for his injury.

Sam Antonacci (L) LF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Andrew Benintendi (L) DH

Colson Montgomery (L) SS

Randal Grichuk (R) RF

Tristan Peters (L) CF

Chase Meidroth (R) 2B

Drew Romo (S) C

Jeremy Peña (R) SS

Yordan Alvarez (L) DH

Isaac Paredes (R) 3B

Jose Altuve (R) 2B

LaMonte Wade Jr. (L) LF

Christian Walker (R) 1B

Yainer Diaz (R) C

Taylor Trammell (L) CF

Cam Smith (R) RF

Batting Average:  Randal Grichuk (.286)

Hits:  Chase Meidroth (134)

Home Runs:  Munetaka Murakami (29)

RBI:  Colson Montgomery (79)

Stolen Bases:  Sam Antonacci (17)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Hagen Smith (0.82)

Batting Average:  Yordan Alvarez (.316)

Hits:  Yordan Alvarez (155)

Home Runs:  Yordan Alvarez (37)

RBI:  Yordan Alvarez (94)

Stolen Bases:  Cam Smith (10)

Wins:  Peter Lambert (8)

Saves:  Josh Hader (21)

ERA:  Josh Hader (0.74)

Managers:

Chicago White Sox: Will Venable (2nd season)

Houston Astros: Joe Espada (3rd season)