Chicago White Sox vs Boston Red Sox Prediction, Preview and Odds - 08/06/2026

Game Time: 7:10 pm ET, Thursday, August 6, 2026

Venue:  Fenway Park, Boston, MA

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox +157, Red Sox -192; Over/Under:  9 runs

Bet365:  Moneyline odds:  White Sox +160, Red Sox -190; Over/Under:  9 runs

BetMGM:  Moneyline odds:  White Sox +160, Red Sox -190; Over/Under:  9 runs

Chicago White Sox:  59-53 (1st place, AL Central)

Boston Red Sox:  61-51 (3rd place, AL East)

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Chicago White Sox:  5-5 last 10

Boston Red Sox:  8-2 last 10

The White Sox are entering this series off a win and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 59-53 record overall and have a road record of 25-32. This is the series finale of a 3-game series with the Red Sox on Thursday with the 2nd game still to be played on Wednesday. The White Sox lost the series opener on Tuesday. Their offense ranks 14th in the MLB with a .722 OPS. Sean Burke is their starting pitcher on Wednesday while Luis Castillo is making his start in this game on Thursday. He is 3-9 with a 5.06 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 5 ER, 2 HR, and 2 BB with 2 SO on 11 hits through 5 IP against the Los Angeles Dodgers.

The Red Sox are entering this series off a win and completed the sweep in their 3-game series against the Los Angeles Dodgers 3-0 in their last series. They enter this game with a 61-51 record overall and have a home record of 26-29. This is the 3rd game of a 3-game series with the White Sox on Thursday with the 2nd game of this series still to be played on Wednesday. The Red Sox won the 1st game of this series on Tuesday. Their offense ranks 18th in the MLB with a .717 OPS. Sonny Gray is their starting pitcher on Wednesday while Ranger Suarez is making his start in this game on Thursday. He is 4-3 with a 3.15 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 0 homers, and 2 walks with 2 strikeouts on 4 hits through 4.2 innings pitched against the Los Angeles Dodgers.

The current betting odds have the Red Sox listed as a favorite in this game according to Draftkings Sportsbook. The Red Sox have looked good in their games this season with their 61-51 record overall which has them right in the middle of the AL East. They haven't looked good in their own ballpark though with their 26-29 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 59-53 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 25-32 road record this year. The White Sox have had a great turnaround this season with one of the best offenses in MLB, but their pitching hasn't been that great and lately they haven't looked good either, now 5-5 in their last 10 games. The Red Sox have been one of the hottest teams in the league over the last 2 months after having a terrible start to the season. They have had a great pitching staff all season and now their offense is finally starting to pick up too. They have also been rolling lately, now 8-2 in their last 10 games, and they are going to have the better pitching matchup here. Suarez is on the mound for the Red Sox in this one and he has looked great this season. He is 4-3 with a 3.15 ERA and he hasn't been giving up many runs. He did give up 3 earned runs in his last start, but that hasn't been a common theme for him and the team has had a ton of success with him lately, winning 4 games in a row now with him starting. The White Sox are going with Castillo in this one and he hasn't looked great this season. He is 3-9 with a 5.06 ERA and he has been giving up a lot of runs. He is coming off another bad start giving up 5 earned runs which has been a common theme for him and even though he is making his 1st start with the White Sox, the Mariners were having a lot of trouble with him as they lost 3 of their last 4 games with him starting. All signs point to the Red Sox to keep rolling in this one with the better pitching staff. The best way to place a bet here is on the Red Sox to win this game. 

White Sox Red Sox Prediction:  Our MLB Pick for Thursday, August 6, 2026 (7:10 pm ET start time) is Red Sox 8 White Sox 2.

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Chicago White Sox: 33-60 (-7.5 units) on the moneyline against AL East opponents. 160-276 (-55 units) on the moneyline in all games. 70-149 (-41.6 units) on the moneyline in road games. 62-40 UNDER against left-handed starters.

Boston Red Sox: 173-148 (+7.7 units) on the moneyline against right-handed starters. 154-125 (+13.1 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 123-108 (+17.4 units) on the moneyline when playing against a team with a winning record. 30-22 UNDER in home games.

Chicago White Sox:  K. Teel (C) Ten Day IL - Ankle. A. Hays (LF) Sixty Day IL - Calf. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Boston Red Sox:  A. Rutschman (C) Ten Day IL - Wrist. C. Mead (3B) Ten Day IL - Hand. Z. Kelly (RP) Sixty Day IL - Elbow. R. Anthony (LF) Sixty Day IL - Wrist. I. Kiner-Falefa (2B) Ten Day IL - Forearm. G. Crochet (SP) Sixty Day IL - Shoulder. T. Story (SS) Sixty Day IL - Abdomen. K. Crawford (SP) Sixty Day IL - Wrist. T. Casas (1B) Sixty Day IL - Knee. J. Oviedo (SP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Elbow.

“Pretty good spanking we took. Obviously, the first inning there with Davis, couldn’t find it there, made an adjustment which worked for him, settled in nicely, but got to figure out a way to be on top of that early.” - Will Venable after his team’s loss against the Red Sox in their game on Tuesday. 

“I think we talked a good bit about the small ball and it got a lot of attention because early on, when we kind of first started to get going, it created an identity for us finding ways to score runs when we weren’t hitting for power.” - Chad Tracy after his team’s win against the White Sox in their game on Tuesday.

Chase Meidroth (R) 2B

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Randal Grichuk (R) LF

Colson Montgomery (L) DH

Joey Bart (R) C

Brenton Doyle (R) CF

Braden Montgomery (S) RF

Luisangel Acuña (R) SS

Nick Sogard (S) 2B

Ceddanne Rafaela (R) CF

Wilyer Abreu (L) RF

Willson Contreras (R) 1B

Masataka Yoshida (L) DH

Caleb Durbin (R) 3B

Jarren Duran (L) LF

Andruw Monasterio (R) SS

Connor Wong (R) C

Batting Average:  Brenton Doyle (.500)

Hits:  Chase Meidroth (109)

Home Runs:  Colson Montgomery (25)

RBI:  Miguel Vargas (67)

Stolen Bases:  Luisangel Acuña (15)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Grant Taylor (2.40)

Batting Average:  Jahmai Jones (.385)

Hits:  Ceddanne Rafaela (121)

Home Runs:  Willson Contreras (23)

RBI:  Willson Contreras (69)

Stolen Bases:  Jarren Duran (16)

Wins:  Sonny Gray (13)

Saves:  Aroldis Chapman (27)

ERA:  Erik Miller (0.00)

Managers:

Chicago White Sox: Will Venable (2nd season)

Boston Red Sox: Chad Tracy (Interim)