Chicago White Sox vs Boston Red Sox Prediction, Preview and Odds - 08/05/2026

Game Time: 7:10 pm ET, Wednesday, August 5, 2026

Venue:  Fenway Park, Boston, MA

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox +108, Red Sox -131; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  White Sox +110, Red Sox -130; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  White Sox +110, Red Sox -135; Over/Under:  8.5 runs

Chicago White Sox:  59-52 (1st place, AL Central)

Boston Red Sox:  60-51 (3rd place, AL East)

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Chicago White Sox:  5-5 last 10

Boston Red Sox:  8-2 last 10

The White Sox are entering this series off a win and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 59-52 record overall and have a road record of 25-31. This is the 2nd game of a 3-game series with the Red Sox on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 13th in the MLB with a .724 OPS. Davis Martin is their starting pitcher on Tuesday while Sean Burke is making his start in this game on Wednesday. He is 7-5 with a 3.04 ERA this season. His team won 7 of their last 8 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 2 BB with 10 SO on 3 hits through 6 IP against the New York Yankees.

The Red Sox are entering this series off a win and completed the sweep in their 3-game series against the Los Angeles Dodgers 3-0 in their last series. They enter this game with a 60-51 record overall and have a home record of 25-29. This is the 2nd game of a 3-game series with the White Sox on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 18th in the MLB with a .712 OPS. Patrick Sandoval is their starting pitcher on Tuesday while Sonny Gray is making his start in this game on Wednesday. He is 13-2 with a 2.93 ERA this season. His team won 6 of their last 7 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 0 homers, and 2 walks with 5 strikeouts on 7 hits through 7 innings pitched against the Athletics.

The current betting odds have the Red Sox listed as a slight favorite in this game according to Draftkings Sportsbook. The Red Sox have looked good in their games this season with their 60-51 record overall which has them right in the middle of the AL East. They haven't looked good in their own ballpark though with their 25-29 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 59-52 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 25-31 road record this year. The White Sox have been having a great year as they lead their division with one of the best offenses in MLB too, but lately they have been really up and down, only 5-5 in their last 10 games. The Red Sox had a terrible start to the season and looked like they were done for the year, but they have been one of the hottest teams in the league over the last 2 months, still rolling lately too as they are 8-2 in their last 10 games. The Red Sox are going with Gray in this one and he has looked great this season. He is 13-2 with a 2.93 ERA and the team has been having a ton of success with him lately. He did give up 4 earned runs in his last start, but that hasn't been a common theme for him this year and the team has still won 6 of their last 7 games with him starting. The White Sox are going with Burke in this one and he has looked great this season too. He is 7-5 with a 3.04 ERA and the team has been having a ton of success with him lately. They have won 7 of their last 8 games with him starting and he is coming off another great start in which he gave up no runs, but the bullpen has also been a big issue for the White Sox this season while pitching has been a strength for the Red Sox. The White Sox have also looked a lot better at home this season, so look for the Red Sox to edge them out in this one with the better bullpen being a key factor. The best way to place a bet here is on the Red Sox to win this game. 

White Sox Red Sox Prediction:  Our MLB Pick for Wednesday, August 5, 2026 (7:10 pm ET start time) is Red Sox 4 White Sox 1.

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Chicago White Sox: 33-59 (-6.5 units) on the moneyline against AL East opponents. 160-275 (-54 units) on the moneyline in all games. 70-148 (-40.6 units) on the moneyline in road games. 7-3 UNDER vs. a starting pitcher whose winning percentage is better than 70%.

Boston Red Sox: 172-148 (+6.7 units) on the moneyline against right-handed starters. 153-125 (+12.1 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 122-108 (+16.4 units) on the moneyline when playing against a team with a winning record. 17-10 UNDER vs. an AL starting pitcher whose ERA is 3.70 or better.

Chicago White Sox:  B. Montgomery (RF) Day To Day - Ankle. K. Teel (C) Ten Day IL - Ankle. A. Hays (LF) Sixty Day IL - Calf. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Boston Red Sox:  A. Rutschman (C) Ten Day IL - Wrist. C. Mead (3B) Ten Day IL - Hand. Z. Kelly (RP) Sixty Day IL - Elbow. R. Anthony (LF) Sixty Day IL - Wrist. M. Mayer (2B) Ten Day IL - Forearm. I. Kiner-Falefa (2B) Ten Day IL - Forearm. G. Crochet (SP) Sixty Day IL - Shoulder. T. Story (SS) Sixty Day IL - Abdomen. K. Crawford (SP) Sixty Day IL - Wrist. T. Casas (1B) Sixty Day IL - Knee. J. Oviedo (SP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Elbow.

“Yeah, it was huge. To get two runs early is, obviously, a nice way to start the game. And really, because of those two errors, Obviously, they're such a good defensive team that they usually make those. But a good job by our guys to take advantage. We're just a really competitive group. When you compete, take advantage of those opportunities, that's a path to winning. We talk about continuing to battle and grind every at-bat and these guys do a great job.” - Will Venable after his team’s win against the Rays in their game on Sunday. 

"They grab a lead, but you find a way to get out of the inning in a one-run ballgame and then respond immediately. They've been doing that for a month. Felt like the game swung in our favor and then we held on from there." - Chad Tracy after his team’s win against the LA Dodgers in their game on Sunday. 

Sam Antonacci (L) LF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Colson Montgomery (L) SS

Andrew Benintendi (L) DH

Tristan Peters (L) CF

Chase Meidroth (R) 2B

Everson Pereira (R) RF

Drew Romo (S) C

Nick Sogard (S) 2B

Ceddanne Rafaela (R) CF

Wilyer Abreu (L) RF

Willson Contreras (R) 1B

Masataka Yoshida (L) DH

Caleb Durbin (R) 3B

Andruw Monasterio (R) SS

Jarren Duran (L) LF

Carlos Narváez (R) C

Batting Average:  Randal Grichuk (.276)

Hits:  Chase Meidroth (108)

Home Runs:  Colson Montgomery (25)

RBI:  Miguel Vargas (66)

Stolen Bases:  Luisangel Acuña (15)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Grant Taylor (2.40)

Batting Average:  Jahmai Jones (.385)

Hits:  Ceddanne Rafaela (120)

Home Runs:  Willson Contreras (23)

RBI:  Willson Contreras (67)

Stolen Bases:  Jarren Duran (15)

Wins:  Sonny Gray (13)

Saves:  Aroldis Chapman (27)

ERA:  Aroldis Chapman (1.67)

Managers:

Chicago White Sox: Will Venable (2nd season)

Boston Red Sox: Chad Tracy (Interim)