Chicago Cubs vs Toronto Blue Jays Prediction, Preview and Odds - 08/13/2025

Game Time: 7:07 pm ET, Wednesday, August 13, 2025

Venue:  Rogers Centre, Toronto, ON

Where to Watch:  MARQ, Sportsnet

DraftKings:  Moneyline odds:  Cubs +101, Blue Jays -123; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Cubs +100, Blue Jays -120; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Cubs +100, Blue Jays -120; Over/Under:  8.5 runs

Chicago Cubs:  67-50 (2nd place, NL Central)

Toronto Blue Jays:  69-50 (1st place, AL East)

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Chicago Cubs:  5-5 last 10

Toronto Blue Jays:  6-4 last 10

The Cubs are entering this series off a loss and lost their 3-game series against the St Louis Cardinals 2-1 in their last series. They enter this game with a 67-50 record overall and have a road record of 31-28. This is the 2nd game of a 3-game series with the Blue Jays on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 5th in the MLB with a .760 OPS. Ben Brown is their starting pitcher on Tuesday while rookie pitcher Cade Horton is making his start in this game on Wednesday. He is 6-3 with a 3.18 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 0 BB with 6 SO on 2 hits through 5.2 IP against the Cincinnati Reds.

The Blue Jays are entering this series off a win and lost their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 69-50 record overall and have a home record of 38-19. This is the 2nd game of a 3-game series with the Cubs on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 3rd in the MLB with a .767 OPS. José Berríos is their starting pitcher on Tuesday while Kevin Gausman is making his start in this game on Wednesday. He is 8-8 with a 3.85 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 2 walks with 8 strikeouts on 3 hits through 7 innings pitched against the Colorado Rockies.

The current betting odds have the Blue Jays listed as a slight favorite in this game according to Draftkings Sportsbook. The Blue Jays have looked great in their games this season with their 69-50 record overall which has them right at the top of the AL East with one of the best records in the MLB. They have also looked great in their own ballpark this year with their 38-19 home record. Meanwhile, the Cubs have looked really good in their games this season with their 67-50 record overall which has them right near the top of the NL Central. They have been a good road team too with their 31-28 road record this season. Both of these teams have solid starters in this one, but the Blue Jays have been the slightly hotter team lately as they are 6-4 in their last 10 games and they have been rolling over the last few weeks, now with one of the best records in the MLB. They are going to have Gausman on the mound here and he has looked good this season. He is 8-8 with a 3.85 ERA and he hasn't been giving up many runs lately. He is coming off another good start in which he gave up 1 earned run and his team has been having success with him lately too, winning 3 of their last 4 games with him starting. The Cubs are going with their rookie Horton in this one and he has also looked good this season. He is 6-3 with a 3.18 ERA and has looked better in his starts lately, but he still lacks experience pitching in the MLB and this isn't a great situation to be in, pitching on the road against one of the best offenses in the MLB and one of the best home teams too. The team has won 3 games in a row with him starting and he didn't give up any runs in his last start either, but he is due for a bad start and this will be the game. The Blue Jays have the edge at home in this one. The best way to place a bet here is on the Blue Jays to win this game. 

Cubs Blue Jays Prediction:  Our MLB Pick for Wednesday, August 13, 2025 (7:07 pm ET start time) is Blue Jays 4 Cubs 3.

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Chicago Cubs: 23-16 (+8 units) on the moneyline against AL East opponents. 234-207 (+10.2 units) on the moneyline in all games. 77-55 (+18.6 units) on the moneyline in an inter-league game. 28-16 OVER when the money line is +125 to -125.

Toronto Blue Jays: 232-213 (-10.1 units) on the moneyline in all games. 120-99 (-11 units) on the moneyline in home games. 132-109 (-24.7 units) on the moneyline as a favorite of -110 or higher. 25-11 OVER when playing against a good team (Win Pct. 54% to 62%).

Chicago Cubs:  M. Soroka (SP) Fifteen Day IL - Shoulder. M. Amaya (C) Sixty Day IL - Oblique. J. Taillon (SP) Fifteen Day IL - Calf. E. Morgan (RP) Sixty Day IL - Elbow. J. Assad (RP) Sixty Day IL - Oblique. J. Steele (SP) Sixty Day IL - Elbow.

Toronto Blue Jays:  G. Springer (RF) Seven Day IL - Head. B. Francis (SP) Sixty Day IL - Shoulder. R. Burr (RP) Sixty Day IL - Shoulder. N. Sandlin (RP) Fifteen Day IL - Elbow. A. Gimenez (2B) Ten Day IL - Ankle. Y. Garcia (RP) Fifteen Day IL - Ankle. A. Santander (RF) Sixty Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. A. Manoah (SP) Sixty Day IL - Elbow. A. Bastardo (SP) Sixty Day IL - Elbow.

“We didn’t create enough scoring opportunities.” - Craig Counsell after his team’s loss against the Cardinals in their game on Sunday.

“It’s a great effort right there from everybody -- really everybody. I think we used everybody except Tommy [Nance] and Buddy [Kennedy] today, so it’s what we can do. When we play our kind of game, we can beat and play with anyone.” - John Schneider after his team’s win against the LA Dodgers in their game on Sunday.

Michael Busch (L) 1B

Seiya Suzuki (R) DH

Kyle Tucker (L) RF

Carson Kelly (R) C

Pete Crow-Armstrong (L) CF

Ian Happ (S) LF

Nico Hoerner (R) 2B

Dansby Swanson (R) SS

Matt Shaw (R) 3B

Nathan Lukes (L) RF

Bo Bichette (R) SS

Vladimir Guerrero Jr. (R) 1B

Addison Barger (L) 3B

Ty France (R) DH

Daulton Varsho (L) CF

Ernie Clement (R) 2B

Joey Loperfido (L) LF

Tyler Heineman (S) C

Batting Average:  Nico Hoerner (.291)

Hits:  Nico Hoerner (125)

Home Runs:  Pete Crow-Armstrong (27)

RBI:  Seiya Suzuki (84)

Stolen Bases:  Pete Crow-Armstrong (30)

Wins:  Matthew Boyd (11)

Saves:  Daniel Palencia (15)

ERA:  Michael Fulmer (0.00)

Batting Average:  Joey Loperfido (.382)

Hits:  Bo Bichette (147)

Home Runs:  Vladimir Guerrero (19)

RBI:  Bo Bichette (78)

Stolen Bases:  George Springer (12)

Wins:  Chris Bassitt (11)

Saves:  Jeff Hoffman (26)

ERA:  Ryan Burr (0.00)

Managers:

Chicago Cubs: Craig Counsell (2nd season)

Toronto Blue Jays: John Schneider (4th season)