by Rod Pearson
Friday, Oct 10, 2025
Game Time: 8:08 pm ET, Saturday, October 11, 2025
Venue: American Family Field, Milwaukee, WI
Where to Watch: TBS, truTV, HBO MAX
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Cubs +110, Brewers -130; Over/Under: 7.5 runs
Bet365: Moneyline odds: Cubs +110, Brewers -130; Over/Under: 7.5 runs
BetMGM: Moneyline odds: Cubs +110, Brewers -130; Over/Under: 7.5 runs
Season Record
Chicago Cubs: 92-70 (2nd place, NL Central)
Milwaukee Brewers: 97-65 (1st place, NL Central)
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Recent Form
Chicago Cubs: 7-3 last 10
Milwaukee Brewers: 4-6 last 10
Chicago Cubs vs Milwaukee Brewers Preview and Analysis
The Cubs are entering this series off a win and won their best of 3-game series against the San Diego Padres 2-1 in the National League Wild Card. They finished the regular season with a 92-70 record overall and had a road record of 42-39. This is the series finale of a best 3 out of 5 game series with the Brewers on Saturday for the National League Division Series. The Cubs lost the series opener on Saturday, lost the 2nd game on Monday, won the 3rd game on Wednesday, and won the 4th game on Thursday. Their offense ranks 7th in the MLB with a .750 OPS. Matthew Boyd was their starting pitcher on Thursday while Shota Imanaga is making his start in this game on Saturday. He is 9-8 with a 3.73 ERA this season. His team lost their last 4 straight games this season with him making an appearance. In his last MLB start, he allowed 4 ER, 2 HR, and 0 BB with 3 Ks on 5 hits through 2.2 IP against the Milwaukee Brewers.
The Brewers are entering this series off a win and lost their 3-game series against the Cincinnati Reds 2-1 to end the regular season. They finished the regular season with a 97-65 record overall and had a home record of 52-29. This is the 5th game of a best 3 out of 5 game series with the Cubs on Saturday for the NLDS. The Brewers won the 1st game of this series on Saturday, won the 2nd game on Monday, lost the 3rd game on Wednesday, and lost the 4th game on Thursday. Their offense ranks 11th in the MLB with a .735 OPS. Freddy Peralta was their starting pitcher on Thursday while Jose Quintana is making his start in this game on Saturday. He is 11-7 with a 3.96 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB start, he allowed 0 earned runs, 0 homers, and 1 BB with 2 strikeouts on 2 hits through 3 innings played against the Chicago Cubs.
Cubs vs Brewers Prediction
The current betting odds have the Brewers listed as a slight favorite in this game according to Draftkings Sportsbook. The Cubs have won 2 games in a row now to even up this series 2-2. They have also been the hotter team lately as they are 7-3 in their last 10 games while the Brewers are only 4-6, and the Cubs also played in the Wild Card. The Brewers do have the better pitching matchup though and they have also won both home games in this series. Quintana is on the mound for the Brewers in this one and he has looked good this season. He is 11-7 with a 3.96 ERA and he hasn't been giving up many runs lately. He did pitch 3 innings against the Cubs the other night, but he looked great as he gave up no runs and really stopped the bleeding for the Brewers in that game. Meanwhile, the Cubs are going with Imanaga in this one and he has looked good this season. He is 9-8 with a 3.73 ERA, but he hasn't looked great lately. He got shelled by the Brewers earlier in this series, giving up 4 earned runs without going 3 full innings, and the team has also been struggling with him, losing 4 games in a row now with him on the mound. The Cubs had a nice comeback at home in this series, but the Brewers are going to bounce back at home with the better pitching matchup. The best way to place a bet here is on the Brewers to win this game.
Cubs Brewers Prediction: Our MLB Pick for Saturday, October 11, 2025 (8:08 pm ET start time) is Brewers 5 Cubs 1.
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MLB Betting Trends
Chicago Cubs: 119-126 (-6.2 units) on the moneyline in road games. 107-140 (-38.3 units) on the moneyline when the money line is +125 to -125. 62-65 (-12.4 units) on the moneyline against left-handed starters. 19-10 UNDER after 3 consecutive games versus a division rival.
Milwaukee Brewers: 285-211 (+50.1 units) on the moneyline in all games. 150-99 (+19.2 units) on the moneyline in home games. 142-108 (+33.3 units) on the moneyline when the money line is +125 to -125. 28-14 UNDER revenging a loss vs opponent as a road favorite.
Key Injuries
Chicago Cubs: C. Horton (SP) Fifteen Day IL - Ribs. O. Caissie (RF) Seven Day IL - Concussion. R. Brasier (RP) Fifteen Day IL - Groin. M. Amaya (C) Ten Day IL - Ankle. J. Steele (SP) Sixty Day IL - Elbow.
Milwaukee Brewers: J. Chourio (CF) Day To Day - Hamstring. B. Woodruff (SP) Fifteen Day IL - Lat. S. Miller (RP) Sixty Day IL - Elbow. L. Henderson (SP) Sixty Day IL - Elbow. J. Montgomery (SP) Sixty Day IL - Elbow. G. Mitchell (CF) Sixty Day IL - Oblique. C. Thomas (SP) Sixty Day IL - Elbow.
Notable Quotes
“He delivered a great one tonight. I know it was really important to him after Game 1, how he pitched tonight. He gave us exactly what we needed.” - Craig Counsell after his team’s win against the Brewers in game 4 of this series on Thursday.
“The Cubs earned it. They had their backs against the wall, and they played great these last two games.” - Pat Murphy after his team’s loss against the Cubs in game 4 of this series on Thursday.
Starting Lineups
Chicago Cubs
Michael Busch (L) 1B
Nico Hoerner (R) 2B
Kyle Tucker (L) DH
Seiya Suzuki (R) RF
Ian Happ (S) LF
Carson Kelly (R) C
Pete Crow-Armstrong (L) CF
Dansby Swanson (R) SS
Matt Shaw (R) 3B
Milwaukee Brewers
Christian Yelich (L) DH
Jackson Chourio (R) LF
William Contreras (R) C
Brice Turang (L) 2B
Andrew Vaughn (R) 1B
Caleb Durbin (R) 3B
Sal Frelick (L) RF
Blake Perkins (S) CF
Joey Ortiz (R) SS
Statistical Leaders
Chicago Cubs
Batting Average: Kevin Alcantara (.364)
Hits: Nico Hoerner (178)
Home Runs: Michael Busch (34)
RBI: Seiya Suzuki (103)
Stolen Bases: Pete Crow-Armstrong (35)
Wins: Matthew Boyd (14)
Saves: Daniel Palencia (22)
ERA: Michael Fulmer (0.00)
Milwaukee Brewers
Batting Average: Andrew Vaughn (.308)
Hits: Brice Turang (168)
Home Runs: Christian Yelich (29)
RBI: Christian Yelich (103)
Stolen Bases: Brice Turang (24)
Wins: Freddy Peralta (17)
Saves: Trevor Megill (30)
ERA: Abner Uribe (1.67)
Managers:
Chicago Cubs: Craig Counsell (2nd season)
Milwaukee Brewers: Pat Murphy (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
