Chicago Cubs vs Milwaukee Brewers Prediction, Preview and Odds - 09/09/2026

Game Time: 7:40 pm ET, Wednesday, September 9, 2026

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  ESPN Unlimited, MLB TV

DraftKings:  Moneyline odds:  Cubs +112, Brewers -135; Over/Under:  8 runs

Bet365:  Moneyline odds:  Cubs +110, Brewers -130; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Cubs +110, Brewers -135; Over/Under:  8 runs

Chicago Cubs:  81-64 (2nd place, NL Central)

Milwaukee Brewers:  89-56 (1st place, NL Central)

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Chicago Cubs:  5-5 last 10

Milwaukee Brewers:  5-5 last 10

The Cubs are entering this series off a loss and won their 3-game series against the Miami Marlins 2-1 in their last series. They enter this game with an 81-64 record overall and have a road record of 40-33. This is the series finale of a 3-game series with the Brewers on Wednesday with the 2nd game still to be played on Tuesday. The Cubs lost the series opener on Monday. Their offense ranks 1st in the MLB with a .770 OPS. David Peterson is their starting pitcher on Tuesday while Kevin Gausman is making his start in this game on Wednesday. He is 9-11 with a 4.38 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 1 HR, and 1 BB with 9 SO on 5 hits through 7 IP against the Milwaukee Brewers.

The Brewers are entering this series off a loss and lost their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with an 89-56 record overall and have a home record of 48-25. This is the 3rd game of a 3-game series with the Cubs on Wednesday with the 2nd game of this series still to be played on Tuesday. The Brewers won the 1st game of this series on Monday. Their offense ranks 5th in the MLB with a .738 OPS. Jacob Misiorowski is their starting pitcher on Tuesday while Logan Henderson is making his start in this game on Wednesday. He is 9-3 with a 2.48 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 0 walks with 7 strikeouts on 3 hits through 7 innings pitched against the Chicago Cubs.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 89-56 record overall which has them right at the top of the NL Central with the best record in MLB. They have looked great in their own ballpark too with their 48-25 home record this season. Meanwhile, the Cubs have looked really good in their games this season with their 81-64 record overall which has them right near the top of the NL Central. They have been a good road team too with their 40-33 road record this year. The Brewers are 5-5 in their last 10 games and haven't looked great lately, but the Cubs are also 5-5 in their last 10 games and the Brewers will have the better pitching matchup here. The Brewers are going with Henderson in this one and he has looked great this season. He is 9-3 with a 2.48 ERA and he hasn't been giving up many runs all year. He is coming off another good start giving up 2 earned runs which has been a common theme for him and the team has been having a ton of success with him lately too, winning 3 of their last 4 games with him starting. The Cubs are going with Gausman in this one and he hasn't looked great this season. He is 9-11 with a 4.38 ERA and has been giving up quite a few runs all year. He only gave up 1 earned run in his last start and the team has been having more success with him lately, winning 4 games in a row now with him starting, but that hasn't been a common theme for him this year. He had a lot of trouble when he was pitching for the Blue Jays earlier this year and the Cubs bullpen has also been a disaster this season, so he won't get much help there. Look for the Brewers to take advantage of this pitching matchup at home with one of the best home records in the league. The best way to place a bet here is on the Brewers to win this game. 

Cubs Brewers Prediction:  Our MLB Pick for Wednesday, September 9, 2026 (7:40 pm ET start time) is Brewers 6 Cubs 2.

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Chicago Cubs: 65-68 (-14.6 units) on the moneyline when the total is 7 to 7.5. 77-75 (-8.3 units) on the moneyline against division opponents. 37-47 (-11 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 6-3 UNDER on the road vs. a team with a good bullpen whose ERA is 3.45 or better.

Milwaukee Brewers: 283-199 (+52.5 units) on the moneyline in all games. 150-92 (+26.3 units) on the moneyline in home games. 183-110 (+24.7 units) on the moneyline as a favorite of -110 or higher. 22-13 UNDER at home with a money line of -100 to -150.

Chicago Cubs:  I. Happ (LF) Day To Day - Knee. P. Maton (RP) Sixty Day IL - Knee. E. Cabrera (SP) Fifteen Day IL - Blister. D. Swanson (SS) Ten Day IL - Side. B. Brown (RP) Sixty Day IL - Neck. G. Hollowell (RP) Fifteen Day IL - Shoulder. R. Martin (RP) Sixty Day IL - Elbow. P. Hodge (RP) Sixty Day IL - Elbow. C. Horton (SP) Sixty Day IL - Forearm. H. Harvey (RP) Sixty Day IL - Tricep. J. Steele (SP) Sixty Day IL - Elbow. T. Austin (1B) Sixty Day IL - Knee. S. Miller (RP) Sixty Day IL - Elbow.

Milwaukee Brewers:  G. Anderson (RP) Fifteen Day IL - Biceps. B. Wilson (RP) Fifteen Day IL - Back. R. Zastryzny (RP) Sixty Day IL - Shoulder. B. Woodruff (SP) Sixty Day IL - Shoulder. Q. Priester (SP) Sixty Day IL - Wrist. B. Fitzpatrick (RP) Sixty Day IL - Elbow. A. Zerpa (RP) Sixty Day IL - Forearm.

“Pete had another nice day. Obviously he’s just playing at a super high level. But, [it was] not enough.” - Craig Counsell after his team’s loss against the Brewers in their game on Monday. 

“Sometimes I feel like I was born for those moments. Other times, I like the pressure that those moments bring. I don’t know why, but I know I enjoy them.” - Jackson Chourio after their win against the Cubs in their game on Monday. 

Pete Crow-Armstrong (L) CF

Seiya Suzuki (R) DH

Alex Bregman (R) 3B

Tyrone Taylor (R) LF

Nico Hoerner (R) SS

Matt Shaw (R) RF

Carson Kelly (R) C

BJ Murray Jr. (S) 1B

Pedro Ramírez (S) 2B

Jackson Chourio (R) LF

Brice Turang (L) 2B

William Contreras (R) C

Andrew Vaughn (R) 1B

Christian Yelich (L) DH

Luis Lara (S) RF

Cooper Pratt (R) SS

Garrett Mitchell (L) CF

Joey Ortiz (R) 3B

Batting Average:  Gabriel Arias (.429)

Hits:  Pete Crow-Armstrong (157)

Home Runs:  Pete Crow-Armstrong (41)

RBI:  Pete Crow-Armstrong (97)

Stolen Bases:  Pete Crow-Armstrong (35)

Wins:  Shota Imanaga (9)

Saves:  Jacob Webb (9)

ERA:  Ty Blach (0.00)

Batting Average:  Jihwan Bae (.500)

Hits:  William Contreras (138)

Home Runs:  Jake Bauers (24)

RBI:  Brice Turang (85)

Stolen Bases:  David Hamilton (27)

Wins:  Jacob Misiorowski (14)

Saves:  Trevor Megill (27)

ERA:  Easton McGee (0.00)

Managers:

Chicago Cubs: Craig Counsell (3rd season)

Milwaukee Brewers: Pat Murphy (3rd season)