Chicago Bears vs San Francisco 49ers Prediction, Preview and Odds - 12/28/2025

Game Time: 8:20 pm ET, Sunday, December 28, 2025

Venue:  Levi's Stadium, Santa Clara, CA

Where to Watch:  NBC, Peacock

DraftKings:  Point Spread:  Bears +3, 49ers -3; Over/Under:  52.5 points

Bet365:  Point Spread:  Bears +3, 49ers -3; Over/Under:  52.5 points

BetMGM:  Point Spread:  Bears +3, 49ers -3; Over/Under:  52.5 points

Chicago Bears:  11-4 (1st place, NFC North)

San Francisco 49ers:  11-4 (2nd place, NFC West)

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Chicago Bears:  won their last game at home against the Green Bay Packers 22-16 in overtime. 

San Francisco 49ers:  won their last game on the road against the Indianapolis Colts 48-27.

The Bears are entering this game with an 11-4 record overall and they have a 2-3 record in their divisional games too. They are 6-1 in their home games, 5-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Green Bay Packers 22-16 in OT. Caleb Williams was the starting QB and he completed 19/34 passes for 250 passing yards, 2 touchdowns, and 0 interceptions. D'Andre Swift led the team in rushing yards with 58. DJ Moore led the receivers with 97 receiving yards on 5 receptions and 1 TD. T. J. Edwards led the defense in that game with 5 solo tackles and 5 assisted tackles while Montez Sweat led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The 49ers are entering this game with an 11-4 record overall and they have a 4-1 record in their divisional games too. They are 4-2 in their home games, 7-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Indianapolis Colts 48-27. Brock Purdy was the starting QB and he completed 25/34 passes for 295 passing yards, 5 touchdowns, and 1 interception. Christian McCaffrey led the team in rushing yards with 117. George Kittle led the receivers with 115 receiving yards on 7 receptions and 1 TD. Darrell Luter Jr. led the defense in that game with 5 solo tackles and 1 assisted tackle while Alfred Collins and CJ West each led the defense in sacks with 1. Dee Winters came away with the only interception for them in that one.

The current betting odds have the 49ers listed as a 3 point favorite in this game according to Draftkings Sportsbook. The 49ers have looked really good in their games this season with their 11-4 record overall which has them right near the top of the NFC West with one of the best records in the entire NFL. They have looked good on their home field too with their 4-2 home record this year. Meanwhile, the Bears have looked really good in their games this season with their 11-4 record overall which has them right at the top of the NFC North with one of the best records in the entire NFL. They have been a good road team too with their 5-3 road record. Both of these teams are trying to win their respective divisions and both of these teams still have a chance at the number 1 seed in the NFC, and this is going to be a huge game for that. The Bears have been rolling in their games lately and they are going to have a ton of momentum off a 22-16 win over the Packers. They had a great comeback late in that game, but they did not look good for most of it and this isn't a team they can have a slow start against. The Bears have still been really up and down on offense in their wins and their defense hasn't looked great either as they do give up a lot of points. This 49ers defense hasn't looked any better lately, also giving up a ton of points, but a lot of that has also come in garbage time as they make plays when they need to in close games. The 49ers are off a 48-27 win over the Colts in their last one and they have also been rolling in their games lately with Purdy slinging the ball around in that offense. The Bears have a solid team and have been a great story this year, but a majority of their losses have come in road games this season, and the 49ers still have the more reliable players and coaching staff with experience in these situations. The best way to place a bet here is on the 49ers to cover the spread in this game. 

Bears 49ers Prediction:  Our NFL Pick for Sunday, December 28, 2025 (8:20 pm ET start time) is 49ers 30 Bears 23.

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Chicago Bears: 26-19 ATS in all games. 8-1 ATS after a win by 6 or less points. 14-5 ATS after playing a game at home. 11-5 ATS when playing against a team with a winning record. 11-6 OVER versus poor defensive teams - allowing 5.65 yards/play or more. 

San Francisco 49ers: 1-6 ATS against NFC North division opponents. 4-9 ATS as a home favorite of 7 points or less. 6-12 ATS after scoring 30 points or more last game. 9-2 OVER when playing against a good team (Win Pct. 60% to 75%). 12-4 OVER vs. good offensive teams - scoring 24 or more points/game.

Chicago Bears:  None.

San Francisco 49ers:  None.

“This is a special group. I felt that early in the season. You get with some of those wins — the Raiders game and the Washington game — and you start feeling it, the belief coming. This group — I'm talking about coaches and players combined — it’s rare. It really is.” - Ben Johnson after his team’s win against the Packers in their last game. 

“He was awesome, he played really well. I got on him for a couple throws he missed, but it was pretty close to a perfect game. He did a hell of a job.” - Kyle Shanahan after his team’s win against the Colts in their last game. 

WR Zaccheaus, Olamide

WR Moore, DJ

WR Duvernay, Devin

TE Kmet, Cole

QB Williams, Caleb

RB Swift, D'Andre

WR Bourne, Kendrick

WR Jennings, Jauan

WR Robinson, Demarcus

TE Kittle, George

QB Purdy, Brock

RB McCaffrey, Christian

FB Juszczyk, Kyle

Passing: Caleb Williams (3,400)

Rushing: D'Andre Swift (993)

Receiving: DJ Moore (664)

Touchdowns: D'Andre Swift (8)

Passing: Mac Jones (2,151)

Rushing: Christian McCaffrey (1,039)

Receiving: Christian McCaffrey (849)

Touchdowns: Christian McCaffrey (16)

Coaches:

Chicago Bears: Ben Johnson (1st season)

San Francisco 49ers: Kyle Shanahan (9th season)