Game Time: 1:00 pm ET, Sunday, September 14, 2025
Venue: Ford Field, Detroit, MI
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Bears +6, Lions -6; Over/Under: 47.5 points
Bet365: Point Spread: Bears +5.5, Lions -5.5; Over/Under: 47.5 points
BetMGM: Point Spread: Bears +5.5, Lions -5.5; Over/Under: 47 points
Season Record
Chicago Bears: 0-1 (3rd place, NFC North)
Detroit Lions: 0-1 (4th place, NFC North)
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Recent Form
Chicago Bears: lost their last game at home against the Minnesota Vikings 27-24.
Detroit Lions: lost their last game on the road against the Green Bay Packers 27-13.
Chicago Bears vs Detroit Lions Preview and Analysis
The Bears are entering this game with a 0-1 record overall and they have a 0-1 record in their divisional games too. They are 0-1 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Minnesota Vikings 27-24. Caleb Williams was the starting QB and he completed 21/35 passes for 210 passing yards, 1 touchdown, and 0 interceptions. Caleb Williams led the team in rushing yards with 58 and 1 TD. DJ Moore led the receivers with 68 receiving yards on 3 receptions. Noah Sewell led the defense in that game with 7 solo tackles and 2 assisted tackles while Gervon Dexter Sr., Tanoh Kpassagnon, and Dayo Odeyingbo each led the defense in sacks with 1. Nahshon Wright came away with the only interception for them in that one.
The Lions are entering this game with a 0-1 record overall and they have a 0-1 record in their divisional games too. They are 0-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Green Bay Packers 27-13. Jared Goff was the starting QB and he completed 31/39 passes for 225 passing yards, 1 touchdown, and 1 interception. David Montgomery led the team in rushing yards with 25. Sam LaPorta led the receivers with 79 receiving yards on 6 receptions. Jack Campbell led the defense in that game with 5 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.
Bears vs Lions Prediction
The current betting odds have the Lions listed as a 6 point favorite in this game according to Draftkings Sportsbook. The Lions have a 0-1 record this season and they didn't look good in their season opener. They just had a season where they won 15 games and made a deep run in the playoffs, but they lost their OC and their DC from last season and it took a big toll in week 1. They lost to the Packers 27-13 and were never really in that game, scoring a late TD to make that game look closer, but it was also a tough game to open up the season on the road against a divisional opponent with both coordinators gone. The Packers also have the potential to be one of the best teams in the NFL this season so the Lions will be looking to bounce back at home in week 2 against a weaker divisional opponent. Meanwhile, the Bears have a 0-1 record this season and they looked terrible in their season opener. They lost to the Vikings at home 27-24 with JJ McCarthy making his NFL debut for the Vikings at QB. The defense looked good as they held the Vikings off as long as they could, but the offense looked terrible and couldn't stay on the field. Caleb Williams looked great on that first drive of the game when they opened with a TD, but he was terrible the rest of the game and still has a long way to go to be a starter in the NFL. They also played on Monday night so they are on a shorter week here and this is a terrible situation to be in on the road with the Lions in desperate need of a get right game after their opener. The best way to place a bet here is on the Lions to cover the spread in this game.
Bears Lions Prediction: Our NFL Pick for Sunday, September 14, 2025 (1:00 pm ET start time) is Lions 24 Bears 6.
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NFL Betting Trends
Chicago Bears: 2-8 ATS as a road underdog of 7 points or less. 4-8 ATS in a road game where the total is between 42.5 and 49 points. 7-4 OVER after a loss by 6 or less points. 27-18 OVER after playing on Monday night football.
Detroit Lions: 26-13 ATS in all games. 22-11 ATS as a favorite. 15-8 ATS in all games where the total is between 42.5 and 49 points. 20-12 OVER as a favorite. 9-3 OVER in a home game where the total is between 42.5 and 49 points.
Key Injuries
Chicago Bears: None.
Detroit Lions: None.
Notable Quotes
“We made too many mistakes there late in the game, myself included. There were a number of things I could have done better, there were a number of things a lot of guys could have done better.” - Ben Johnson after his team’s loss against the Vikings in their last game.
“They came out and played outstanding, and we didn’t play good enough. We didn’t coach good enough, including me, and we didn’t play good enough. Like I told the team, it’s tough to go in and not certainly play close to your best game. You hate starting the season off with a loss, and as bad as that is, it’s not what it appears to be.” - Dan Campbell after his team’s loss against the Packers in their last game.
Starting Lineups
Chicago Bears
WR Odunze, Rome
WR Moore, DJ
WR Zaccheaus, Olamide
TE Loveland, Colston
QB Williams, Caleb
RB Swift, D'Andre
Detroit Lions
WR TeSlaa, Isaac
WR Williams, Jameson
WR St. Brown, Amon-Ra
TE LaPorta, Sam
QB Goff, Jared
RB Gibbs, Jahmyr
Statistical Leaders
Chicago Bears
Passing: C. Williams (210)
Rushing: C. Williams (58)
Receiving: D. Moore (68)
Touchdowns: R. Odunze (1)
Detroit Lions
Passing: J. Goff (225)
Rushing: D. Montgomery (25)
Receiving: S. LaPorta (79)
Touchdowns: I. TeSlaa (1)
Coaches:
Chicago Bears: Ben Johnson (1st season)
Detroit Lions: Dan Campbell (5th season)