Carolina Panthers vs New England Patriots Prediction, Preview and Odds - 09/28/2025

Game Time: 1:00 pm ET, Sunday, September 28, 2025

Venue:  Gillette Stadium, Foxborough, MA 

Where to Watch:  FOX

DraftKings:  Point Spread:  Panthers +5.5, Patriots -5.5; Over/Under:  43.5 points

Bet365:  Point Spread:  Panthers +5.5, Patriots -5.5; Over/Under:  43.5 points

BetMGM:  Point Spread:  Panthers +5.5, Patriots -5.5; Over/Under:  43.5 points

Carolina Panthers:  1-2 (2nd place, NFC South)

New England Patriots:  1-2 (2nd place, AFC East)

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Carolina Panthers:  won their last game at home against the Atlanta Falcons 30-0.

New England Patriots:  lost their last game at home against the Pittsburgh Steelers 21-14.

The Panthers are entering this game with a 1-2 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Atlanta Falcons 30-0. Bryce Young was the starting QB and he completed 16/24 passes for 121 passing yards, 0 touchdowns, and 0 interceptions. Chuba Hubbard led the team in rushing yards with 73. Tetairoa McMillan led the receivers with 48 receiving yards on 3 receptions. Christian Rozeboom led the defense in that game with 6 solo tackles and 3 assisted tackles while no one on the defense recorded a sack for them. Mike Jackson and Chau Smith-Wade each came away with 1 interception for them in that one.

 

 

 

The Patriots are entering this game with a 1-2 record overall and they have a 1-0 record in their divisional games too. They are 0-2 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Pittsburgh Steelers 21-14. Drake Maye was the starting QB and he completed 28/37 passes for 268 passing yards, 2 touchdowns, and 1 interception. Drake Maye led the team in rushing yards with 45. Hunter Henry led the receivers with 90 receiving yards on 8 receptions and 2 TDs. Robert Spillane led the defense in that game with 10 solo tackles and 5 assisted tackles while no one on the defense recorded a sack for them. Robert Spillane came away with the only interception for them in that one.

The current betting odds have the Patriots listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. The Patriots haven't looked good in their games this season with their 1-2 record overall. Their only win was against the Dolphins while they have losses against the Raiders and the Steelers, but they didn't look terrible in those losses. Both of their losses were by a touchdown or less and they were in both of those games with a chance to win. Mike Vrabel in his first year coaching the team and still has a lot of work to do, but he has them trending in the right direction this year. Meanwhile, the Panthers haven't looked good in their games this season with their 1-2 record overall. They are coming off their first win of the season, shutting out the Falcons 30-0, but they also looked terrible in their first 2 games. That win was also in their only home game this season, but they looked terrible in their first 2 games on the road and will likely regress back to that team this week. Both of these teams are some of the worst in the NFL this season, but the Panthers have one of the worst defenses along with a really inconsistent offense. The Patriots don't have a great defense, but they at least have some consistency in their offense that will help them win their first home game of the season here. The best way to place a bet here is on the Patriots to cover the spread in this game. 

Panthers Patriots Prediction:  Our NFL Pick for Sunday, September 28, 2025 (1:00 pm ET start time) is Patriots 28 Panthers 17.

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Carolina Panthers: 24-13 ATS on the road off an upset win as an underdog. 37-24 ATS on the road after allowing 14 points or less last game. 31-22 ATS on the road when playing against a bad team (Win Pct. 25% to 40%). 4-1 UNDER on the road when playing against a team with a losing record.

New England Patriots: 13-22 ATS in all games. 4-12 ATS in home games. 2-11 ATS in all games where the total is between 42.5 and 49 points. 1-8 ATS in non-conference games. 6-0 UNDER as a favorite. 6-3 UNDER when playing against a bad team (Win Pct. 25% to 40%).

Carolina Panthers:  P. Jones II (LB) Injured - Hamstring. X. Legette (WR) Injured - Hamstring. T. McMillan (WR) Injured - Calf. J. Sanders (TE) Injured - Ankle. T. Wharton (DL) Injured - Hamstring. D. Wonnum (LB) Injured - Hip. R. Dowdle (RB) Injured - NIR - Rest. J. Horn (CB) Injured - NIR - Rest. T. Moton (OT) Injured - NIR - Rest. H. Renfrow (WR) Injured - NIR - Rest.

New England Patriots:  H. Henry (TE) Injured - Knee. M. Hollins (WR) Injured - Hand. A. Jennings (LB) Injured - Hamstring. C. Davis III (CB) Injured - Achilles. K. Chaisson (LB) Injured - Knee. C. Barmore (DL) Injured - NIR - Other. C. Gonzalez (CB) Injured - Hamstring. M. Mapu (LB) Injured - Neck. J. Wilson (C) Injured - Ankle.

“When you score in every phase, you give yourself a great chance to win.” - Dave Canales after his team’s win against the Falcons in their last game. 

“We don’t need to lose a football game to know that turnovers are very hard to overcome. They erase all the good things that you do.” - Mike Vrabel after his team’s loss against the Steelers in their last game. 

WR McMillan, Tetairoa

WR Moore, David

WR Renfrow, Hunter

TE Tremble, Tommy

QB Young, Bryce

RB Hubbard, Chuba

WR Boutte, Kayshon

WR Hollins, Mack

WR Diggs, Stefon

TE Henry, Hunter

QB Maye, Drake

RB Henderson, TreVeyon

FB Westover, Jack

Passing: Bryce Young (603)

Rushing: Chuba Hubbard (168)

Receiving: Tetairoa McMillan (216)

Touchdowns: Chuba Hubbard (2)

Passing: Drake Maye (785)

Rushing: Rhamondre Stevenson (87)

Receiving: Hunter Henry (165)

Touchdowns: Hunter Henry (2)

Coaches:

Carolina Panthers: Dave Canales (2nd season)

New England Patriots: Mike Vrabel (1st season)