Carolina Panthers vs Arizona Cardinals Prediction, Preview and Odds - 09/14/2025

Game Time: 4:05 pm ET, Sunday, September 14, 2025

Venue:  State Farm Stadium, Glendale, AZ

Where to Watch:  CBS

DraftKings:  Point Spread:  Panthers +6.5, Cardinals -6.5; Over/Under:  44.5 points

Bet365:  Point Spread:  Panthers +7, Cardinals -7; Over/Under:  44 points

BetMGM:  Point Spread:  Panthers +6.5, Cardinals -6.5; Over/Under:  44.5 points

Carolina Panthers:  0-1 (4th place, NFC South)

Arizona Cardinals:  1-0 (2nd place, NFC West)

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Carolina Panthers:  lost their last game on the road against the Jacksonville Jaguars 26-10.

Arizona Cardinals:  won their last game on the road against the New Orleans Saints 20-13.

The Panthers are entering this game with a 0-1 record overall and they have a 0-0 record in their divisional games too. They are 0-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Jacksonville Jaguars 26-10. Bryce Young was the starting QB and he completed 18/35 passes for 154 passing yards, 1 touchdown, and 2 interceptions. Chuba Hubbard led the team in rushing yards with 57. Tetairoa McMillan led the receivers with 68 receiving yards on 5 receptions. Tre'von Moehrig led the defense in that game with 7 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. Jaycee Horn came away with the only interception for them in that one.

 

 

 

The Cardinals are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the New Orleans Saints 20-13. Kyler Murray was the starting QB and he completed 21/29 passes for 163 passing yards, 2 touchdowns, and 0 interceptions. Trey Benson led the team in rushing yards with 69. Marvin Harrison Jr. led the receivers with 71 receiving yards on 5 receptions and 1 TD. Budda Baker led the defense in that game with 5 solo tackles and 5 assisted tackles while Baron Browning led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have the Cardinals listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. The Cardinals have a 1-0 record overall this season and they didn't look great in their season opener, but they did get out of there with a win. They were playing against the Saints who look like they are going to be one of the worst teams in the NFL this year and the Cardinals didn't look great as they struggled to pull away at times, but the defense was good and the offense started to get into a groove near the end. Now the Cardinals are playing their home opener and they are catching a break with another bad team here, playing against the Panthers who have been one of the worst teams in the NFL over the last few seasons. Meanwhile, the Panthers have a 0-1 record overall and they didn't look great in their season opener. They lost to the Jaguars 26-10 and now they are playing their 2nd straight road game to open up the season. The defense wasn't terrible as they held off the Jags as long as they could, but they still don't have a lot of talent on that defense and it is going to be one of the worst in the NFL again this season. The offense also looked terrible as they struggled to move the ball, and the Cardinals don't have a bad defense so they are going to be all over Bryce Young all game. The best way to place a bet here is on the Cardinals to cover the spread in this game. 

Panthers Cardinals Prediction:  Our NFL Pick for Sunday, September 14, 2025 (4:05 pm ET start time) is Cardinals 38 Panthers 13.

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Carolina Panthers: 12-21 ATS in all games. 4-13 ATS as a road underdog. 5-10 ATS after playing their last game on the road. 11-6 OVER in all games where the total is between 42.5 and 49 points. 

Arizona Cardinals: 11-6 ATS in home games. 10-5 ATS in a home game where the total is between 42.5 and 49 points. 11-6 ATS after playing their last game on the road. 11-5 OVER in home games. 10-4 OVER in a home game where the total is between 42.5 and 49 points.

Carolina Panthers:  A. Evans (CB) Injured - Illness. P. Jones II (LB) Injured - Ankle. H. Renfrow (WR) Injured - Ribs. R. Hunt (OG) Injured - Foot. D. Lewis (OG) Injured - Shoulder. A. Robinson (DL) Injured - Groin. T. Wharton (DL) Injured - Hamstring. I. Ekwonu (OT) Injured - Illness.

Arizona Cardinals:  T. Reiman (TE) Injured - Foot. C. Simon (LB) Injured - Concussion. K. Beachum (OG) Injured - Rest. W. Hernandez (OG) Injured - Knee. B. Gillikin (P) Injured - Back. J. Gaines II (OG) Injured - Thumb.

“Obviously no one likes to lose, but it’s Week 1. We’re going to watch it (Monday). We’re going to wear it. We’re going to see where we can grow, and after that, we’re going to flush it.” - Bryce Young after their loss against the Jags in their last game. 

“I woke up with something, but I wasn’t going to miss the game. I don’t really know what sickness could make me miss a game.” - Kyler Murray after their win against the Saints in their last game. 

WR McMillan, Tetairoa

WR Legette, Xavier

WR Renfrow, Hunter

TE Sanders, Ja'Tavion

QB Young, Bryce

RB Hubbard, Chuba

WR Harrison Jr., Marvin

WR Jones, Zay

WR Wilson, Michael 

TE McBride, Trey

QB Murray, Kyler

RB Conner, James

Passing: B. Young (154)

Rushing: C. Hubbard (57)

Receiving: T. McMillan (68)

Touchdowns: C. Hubbard (1)

Passing: K. Murray (163)

Rushing: T. Benson (69)

Receiving: M. Harrison Jr. (71)

Touchdowns: M. Harrison Jr. (1)

Coaches:

Carolina Panthers: Dave Canales (2nd season)

Arizona Cardinals: Jonathan Gannon (3rd season)