BYU Cougars vs Iowa State Cyclones Prediction, Picks and Game Preview - 10/25/2025

Game Time: 3:30 pm ET, Saturday, October 25, 2025

Venue:  Jack Trice Stadium, Ames, IA

Where to Watch:  FOX

DraftKings:  Point Spread:  BYU +2.5, ISU -2.5; Over/Under:  49.5 points

Bet365:  Point Spread:  BYU +2.5, ISU -2.5; Over/Under:  49 points

BetMGM:  Point Spread:  BYU +2.5, ISU -2.5; Over/Under:  49.5 points

BYU Cougars:  7-0 (4-0) (1st place, Big 12)

Iowa State Cyclones:  5-2 (2-2) (8th place, Big 12)

Do not miss out on our expert handicapper analysis! Hollywood Sports is on a HOT STREAK in college football on a 12-1 CFB RUN for +$10,850 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

BYU Cougars:  won their last game at home against the Utah Utes 24-21.

Iowa State Cyclones:  lost their last game on the road against the Colorado Buffaloes 24-17.

BYU is entering this game with a 7-0 record overall and they have a 4-0 record in their conference games too. They are 4-0 in their home games, 3-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Utah 24-21. Bear Bachmeier was the starting QB and he completed 13/22 passes for 166 passing yards, 1 touchdown, and 0 interceptions. LJ Martin led the team in rushing yards with 122. Parker Kingston led the receivers with 50 receiving yards on 4 receptions. Faletau Satuala led the defense in that game with 8 solo tackles and 3 assisted tackles while Jack Kelly, Max Alford, and Hunter Clegg each led the defense in sacks with 1. Tanner Wall came away with the only interception for them in that one.

 

 

 

Iowa State is entering this game with a 5-2 record overall and they have a 2-2 record in their conference games too. They are 3-0 in their home games, 1-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Colorado 24-17. Rocco Becht was the starting QB and he completed 18/33 passes for 205 passing yards, 0 touchdowns, and 1 interception. Abu Sama III led the team in rushing yards with 177 and 2 TDs. Benjamin Brahmer led the receivers with 56 receiving yards on 5 receptions. Ta'Shawn James led the defense in that game with 6 solo tackles and 3 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

The current betting odds have BYU listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. BYU has looked great in their games this season with their 7-0 record overall and their 4-0 conference record which has them right at the top of the Big 12. They are currently ranked inside the top 25 and they are the only undefeated team left in the Big 12. They are off a 24-21 win over Utah in their last one which was a huge win for them and that win is going to give them a ton of momentum going forward. They are now the team to beat in the conference and they have a very real chance of going to the playoff. Meanwhile, Iowa State has looked good in their games this season with their 5-2 record overall, but their 2-2 conference record has them right in the middle of the Big 12. They had a really hot start to the season and were looking like the team to beat in the conference early on, but now they have lost 2 games in a row. They are coming out of their bye week so they have had some extra time to rest for this game, but they are off a 24-17 loss to a bad Colorado team in their last one and their offense hasn't looked right in their last 2 games. BYU does have a really good defense that hasn't been giving up many points all season and this is going to be another tough day for the Iowa State offense. Iowa State's defense hasn't looked great either and BYU has shown on multiple occasions that no lead is safe against them as they continue to find ways to win. The best way to place a bet here is on BYU to cover the spread in this game. 

BYU Iowa State Prediction:  Our NCAAF Pick for Saturday, October 25, 2025 (3:30 pm ET start time) is BYU 27 Iowa State 21.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this BYU Cougars Iowa State Cyclones prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

BYU Cougars: 7-2 ATS when the line is +3 to -3. 8-4 ATS off a home win. 10-4 ATS after playing a game at home. 7-2 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 7-3 OVER as a road underdog. 8-4 OVER off a win against a conference rival. 5-1 OVER off an upset win as an underdog.

Iowa State Cyclones: 4-7 ATS vs. good passing teams averaging 8 or more passing yards/att. 2-6 ATS when playing against a top-level team (Win Pct. > 75%). 5-1 OVER after a bye week. 4-1 OVER off an upset loss as a favorite. 7-2 OVER vs. good teams - outscoring opponents by 10+ PPG on the season.

BYU Cougars:  T. Prassas (S) Questionable - Undisclosed. J. Phillips (WR) Questionable - Undisclosed. S. Moa (RB) Questionable - Undisclosed. M. McKenzie (CB) Questionable - Undisclosed. R. Damuni (S) Questionable - Undisclosed. C. Bryant-Strother (LB) Questionable - Undisclosed.

Iowa State Cyclones:  N. Reinicke (LB) Questionable - Undisclosed. C. Hansen (RB) Questionable - Concussion. J. Cooper (CB) Questionable - Undisclosed. D. Malone (WR) Questionable - Undisclosed. J. Gilbert (DL) Questionable - Undisclosed. K. Konrardy (K) Questionable - Undisclosed. E. Lemos (CB) Questionable - Undisclosed. W. Tompkins (OG) Questionable - Undisclosed. D. Jackson (WR) Questionable - Undisclosed. K. Cummings-Coleman (CB) Questionable - Undisclosed. M. Parkes (WR) Questionable - Undisclosed. J. Jackson (RB) Questionable - Undisclosed. D. Hasert (OG) Questionable - Undisclosed. J. Williams (CB) Out - Undisclosed.

“We knew it would take all three phases to do this, and we knew it would be a fight to the end.” - Kalani Sitake after his team’s win against Utah in their last game. 

“It sounded like they thought that the ball ... it had no impact, that the (defensive pass interference) didn’t happen until after the ball was thrown, which is not true.” - Matt Campbell after his team’s loss against Colorado in their last game. 

WR Roberts, Chase

WR Hagen, Cody

WR Kingston, Parker

TE Ryan, Carsen

QB Bachmeier, Bear

RB Martin, LJ

WR Sowell, Chase

WR Eskildsen, Brett

WR Townsend, Xavier

TE Burkle, Gabe

TE Brahmer, Benjamin

QB Becht, Rocco

RB Hansen, Carson

Passing: Bear Bachmeier (1,386)

Rushing: LJ Martin (774)

Receiving: Chase Roberts (463)

Touchdowns: Bear Bachmeier (8)

Passing: Rocco Becht (1,622)

Rushing: Abu Sama III (481)

Receiving: Brett Eskildsen (334)

Touchdowns: Rocco Becht (7)

Coaches:

BYU Cougars: Kalani Sitake (10th season)

Iowa State Cyclones: Matt Campbell (10th season)