BYU Cougars vs Colorado Buffaloes Prediction, Picks and Game Preview - 09/27/2025

Game Time: 10:15 pm ET, Saturday, September 27, 2025

Venue:  Folsom Field, Boulder, CO

Where to Watch:  ESPN

DraftKings:  Point Spread:  BYU -7, Colorado +7; Over/Under:  48.5 points

Bet365:  Point Spread:  BYU -6.5, Colorado +6.5; Over/Under:  48.5 points

BetMGM:  Point Spread:  BYU -6.5, Colorado +6.5; Over/Under:  48.5 points

BYU Cougars:  3-0 (0-0) (6th place, Big 12)

Colorado Buffaloes:  2-2 (0-1) (13th place, Big 12)

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BYU Cougars:  won their last game on the road against the East Carolina Pirates 34-13.

Colorado Buffaloes:  won their last game at home against the Wyoming Cowboys 37-20.

BYU is entering this game with a 3-0 record overall and they have a 0-0 record in their conference games too. They are 2-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against East Carolina 34-13. Bear Bachmeier was the starting QB and he completed 18/25 passes for 246 passing yards, 1 touchdown, and 0 interceptions. LJ Martin led the team in rushing yards with 101 and 1 TD. Chase Roberts led the receivers with 97 receiving yards on 5 receptions. Raider Damuni led the defense in that game with 6 solo tackles and 2 assisted tackles while Jack Kelly led the defense in sacks with 2. Evan Johnson came away with the only 2 interceptions for them in that one.

 

 

 

Colorado is entering this game with a 2-2 record overall and they have a 0-1 record in their conference games too. They are 2-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Wyoming 37-20. Kaidon Salter was the starting QB and he completed 18/28 passes for 304 passing yards, 3 touchdowns, and 0 interceptions. Kaidon Salter led the team in rushing yards with 86 and 1 TD. Omarion Miller led the receivers with 88 receiving yards on 6 receptions and 1 TD. Arden Walker and Tawfiq Byard each led the defense in that game with 5 solo tackles and 1 assisted tackle while Arden Walker led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.

The current betting odds have BYU listed as a 7 point favorite in this game according to Draftkings Sportsbook. BYU has looked great in their games this season with their 3-0 record overall. They haven't really played any good opponents yet, but their defense has looked really good. They haven't been giving up many points in their 3 games and they have a lot of talent on both sides of the ball, now ranked inside the top 25 too. Meanwhile, Colorado hasn't looked great in their games this season with their 2-2 record overall and their 0-1 conference record which has them right near the bottom of the Big 12. They haven't had an easy schedule to start the year, their 2 losses coming against Georgia Tech and Houston who aren't bad teams, but this game isn't going to be any easier for them with a ranked opponent coming into town now. Colorado doesn't have a good defense this season either so they are going to struggle to slow down this BYU offense, and their offense has also been really inconsistent. They were better in their last game against a bad defense, but BYU isn't going to give them much to work with so this is going to be another offensive struggle for Colorado. BYU will eventually pull away throughout this game with Colorado unable to respond against this defense. The best way to place a bet here is on BYU to cover the spread in this game. 

BYU Colorado Prediction:  Our NCAAF Pick for Saturday, September 27, 2025 (10:15 pm ET start time) is BYU 31 Colorado 17.

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BYU Cougars: 6-1 ATS after a win by 17 or more points. 8-4 ATS versus good offensive teams - averaging 5.9 yards/play or more. 5-2 ATS after allowing 14 points or less last game. 8-4 OVER as a favorite. 9-4 OVER in road lined games. 6-2 OVER after 3 or more consecutive straight up wins.

Colorado Buffaloes: 2-6 ATS off a home win. 0-4 ATS off a home win by 17 points or more. 22-33 ATS against teams with a turnover margin of +1 per game or better. 38-23 OVER after a win by 17 or more points. 18-10 OVER at home vs. good defensive teams who give up 17 or less points/game.

BYU Cougars:  J. Kirkland (DL) Probable - Undisclosed. E. Erickson (TE) Probable - Undisclosed. E. Nawahine (RB) Probable - Undisclosed. F. Satuala (S) Probable - Undisclosed. K. Fonohema (DL) Questionable - Undisclosed. L. Payne (RB) Questionable - Undisclosed. C. Bryant-Strother (LB) Out - Undisclosed. J. Phillips (WR) Out - Undisclosed. J. Kabeya (CB) Out - Undisclosed.

Colorado Buffaloes:  P. Hodge (CB) Probable - Undisclosed. M. French (LB) Probable - Undisclosed. A. McNeill (DL) Probable - Undisclosed. B. Davis-Swain (DL) Probable - Undisclosed. T. Parks (CB) Probable - Undisclosed. K. Salter (QB) Probable - Undisclosed. K. Wade (DL) Questionable - Undisclosed. K. Carpenter (CB) Doubtful - Undisclosed. T. Branch (S) Doubtful - Undisclosed. M. Vickers (CB) Doubtful - Undisclosed. G. Lightfoot (DL) Out - Undisclosed. T. Thomas (DL) Out - Undisclosed. S. Okunlola (DL) Out - Undisclosed. P. Houston (OT) Out - Undisclosed. S. Price (RB) Out - Undisclosed. D. Taylor (RB) Out - Undisclosed. T. Love (S) Out - Undisclosed. R. Johnson (CB) Out - Undisclosed. C. Williams (TE) Questionable - Undisclosed.

“At the beginning, I thought defensively we took them out of their rhythm, out of their fast pace.” - Kalani Sitake after his team’s win against ECU in their last game. 

“I’m happy with the results, but I’m not happy with the finish. I told our young men, too much ha-ha and hee-heeing on the sideline when we got the lead. I wish we could be a little more — have a little more killer instinct in us to really put teams away, like we’re capable of doing.” - Deion Sanders after his team’s win against Wyoming in their last game. 

WR Roberts, Chase

WR Hagen, Cody

WR Kingston, Parker

TE Ryan, Carsen

QB Bachmeier, Bear

RB Martin, LJ

WR Williams, Joseph

WR Brown, Sincere

WR Miller, Dre'lon

TE Atkins, Zach

QB Salter, Kaidon

RB Welch, Micah

Passing: Bear Bachmeier (518)

Rushing: LJ Martin (342)

Receiving: Chase Roberts (185)

Touchdowns: Bear Bachmeier (4)

Passing: Kaidon Salter (565)

Rushing: Kaidon Salter (153)

Receiving: Sincere Brown (203)

Touchdowns: Kaidon Salter (3)

Coaches:

BYU Cougars: Kalani Sitake (10th season)

Colorado Buffaloes: Deion Sanders (3rd season)