Buffalo Bills vs New York Jets Prediction, Preview and Odds - 09/14/2025

Game Time: 1:00 pm ET, Sunday, September 14, 2025

Venue:  MetLife Stadium, East Rutherford, NJ 

Where to Watch:  CBS

DraftKings:  Point Spread:  Bills -7, Jets +7; Over/Under:  45.5 points

Bet365:  Point Spread:  Bills -6.5, Jets +6.5; Over/Under:  45.5 points

BetMGM:  Point Spread:  Bills -6.5, Jets +6.5; Over/Under:  46 points

Buffalo Bills:  1-0 (1st place, AFC East)

New York Jets:  0-1 (2nd place, AFC East)

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Buffalo Bills:  won their last game at home against the Baltimore Ravens 41-40.

New York Jets:  lost their last game at home against the Pittsburgh Steelers 34-32. 

The Bills are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Baltimore Ravens 41-40. Josh Allen was the starting QB and he completed 33/46 passes for 394 passing yards, 2 touchdowns, and 0 interceptions. James Cook led the team in rushing yards with 44 and 1 TD. Keon Coleman led the receivers with 112 receiving yards on 8 receptions and 1 TD. Ed Oliver led the defense in that game with 6 solo tackles and 0 assisted tackles while Ed Oliver and Matt Milano each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Jets are entering this game with a 0-1 record overall and they have a 0-0 record in their divisional games too. They are 0-1 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Pittsburgh Steelers 34-32. Justin Fields was the starting QB and he completed 16/22 passes for 218 passing yards, 1 touchdown, and 0 interceptions. Breece Hall led the team in rushing yards with 107. Garrett Wilson led the receivers with 95 receiving yards on 7 receptions and 1 TD. Quincy Williams led the defense in that game with 4 solo tackles and 2 assisted tackles while Will McDonald IV led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

The current betting odds have the Bills listed as a 7 point favorite in this game according to Draftkings Sportsbook. The Bills have a 1-0 record this season and they didn't look great in their season opener, but they never gave up in that game and found a way to pull off one of the greatest comebacks in NFL history. They were trailing 40-25 to the Ravens in the 4th quarter, but the defense stepped up and the offense was unstoppable for them to come back and win that game 41-40. The offense looked great in that game, but the defense was terrible and couldn't stop the run for the first half. This defense still has lots of talent though and the Ravens do have one of the best offenses in the entire NFL so the Bills are going to fix some things on defense this week and they won't look as bad in this game. Meanwhile, the Jets have a 0-1 record this season, but they didn't look bad in their season opener. They lost at home to the Steelers 34-32, but the offense looked great with Justin Fields. The defense is supposed to be their strength though and they looked terrible in that one. The Steelers couldn't even run the ball much either, yet Rodgers still carved up that defense through the air. That defense is going to be a big issue with the performance Josh Allen just put on in week 1 and as good as the Jets looked on offense, they still aren't the Ravens offense so they are going to be much easier for this Bills defense to stop with no Derrick Henry on the other side. The best way to place a bet here is on the Bills to cover the spread in this game. 

Bills Jets Prediction:  Our NFL Pick for Sunday, September 14, 2025 (1:00 pm ET start time) is Bills 34 Jets 20.

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Buffalo Bills: 60-42 ATS after a win by 6 or less points. 35-22 ATS on the road after allowing 30 points or more last game. 16-10 OVER after 1 or more consecutive wins. 19-11 OVER in games played on turf.

New York Jets: 13-21 ATS in all games. 3-7 ATS as an underdog of 3.5 to 9.5 points. 4-11 ATS after playing a game at home. 7-3 OVER as an underdog of 3.5 to 9.5 points. 8-3 OVER after a loss by 6 or less points.

Buffalo Bills:  None.

New York Jets:  None.

“Josh, he’s always been like that though. He wants the ball in key moments of the game. That’s what the great ones, that’s their mindset. That’s what they want, that's what they do. And he’s never out of it in his mind.” - Sean McDermott after his team’s win against the Ravens in their last game. 

“Man, we can't have turnovers. We can't do it. We have to be a more disciplined team. That's something that will be addressed. You will not be on the field with this team if you're going to cause us to lose games.” - Aaron Glenn after his team’s loss against the Steelers in their last game. 

WR Palmer, Joshua

WR Coleman, Keon

WR Shakir, Khalil

TE Kincaid, Dalton

QB Allen, Josh

RB Cook, James

FB Gilliam, Reggie

WR Wilson, Garrett

WR Reynolds, Josh 

WR Johnson, Tyler

TE Taylor, Mason

QB Fields, Justin

RB Hall, Breece

FB Beck, Andrew

Passing: J. Allen (394)

Rushing: J. Cook (44)

Receiving: K. Coleman (112)

Touchdowns: J. Allen (2)

Passing: J. Fields (218)

Rushing: B. Hall (107)

Receiving: G. Wilson (95)

Touchdowns: J. Fields (2)

Coaches:

Buffalo Bills: Sean McDermott (9th season)

New York Jets: Aaron Glenn (1st season)