by Rod Pearson
Friday, Oct 09, 2026
Game Time: 8:15 pm ET, Monday, October 12, 2026
Venue: SoFi Stadium, Inglewood, CA
Where to Watch: ESPN, ABC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Bills +3, Rams -3; Over/Under: 54.5 points
Bet365: Point Spread: Bills +3, Rams -3; Over/Under: 54.5 points
BetMGM: Point Spread: Bills +3.5, Rams -3.5; Over/Under: 54.5 points
Season Record
Buffalo Bills: 3-1 (1st place, AFC East)
Los Angeles Rams: 2-2 (3rd place, NFC West)
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Buffalo Bills: lost their last game at home against the New England Patriots 29-26.
Los Angeles Rams: won their last game on the road against the Philadelphia Eagles 24-20.
Buffalo Bills vs Los Angeles Rams Preview and Analysis
The Bills are entering this game with a 3-1 record overall and they have a 0-1 record in their divisional games too. They are 2-1 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the New England Patriots 29-26. Josh Allen was the starting QB and he completed 23/33 passes for 253 passing yards, 1 touchdown, and 1 interception. James Cook led the team in rushing yards with 75 and 1 TD. Keon Coleman led the receivers with 116 receiving yards on 6 receptions and 1 TD. Dorian Williams led the defense in that game with 8 solo tackles while T.J. Parker and Ed Oliver each led the defense in sacks with 1. Dee Alford came away with the only interception for them in that one.
The Rams are entering this game with a 2-2 record overall and they have a 0-1 record in their divisional games too. They are 1-0 in their home games, 1-1 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They won their last game against the Philadelphia Eagles 24-20. Matthew Stafford was the starting QB and he completed 32/51 passes for 317 passing yards, 0 touchdowns, and 2 interceptions. Kyren Williams led the team in rushing yards with 80 and 2 TDs. Puka Nacua led the receivers with 125 receiving yards on 9 receptions. Nate Landman led the defense in that game with 10 solo tackles while Byron Young led the defense in sacks with 2.5. No one on the defense came away with an interception for them in that one.
Bills vs Rams Prediction
The current betting odds have the Bills listed as a 3 point underdog in this game according to Draftkings Sportsbook. The Bills have looked good in their games this season with their 3-1 record overall which has them right at the top of the AFC East. They have been a good road team too with their 1-0 road record this year. Meanwhile, the Rams haven't looked great in their games this season with their 2-2 record overall which has them right near the bottom of the NFC West. They have looked good on their home field though with their 1-0 home record this season. The Rams entered the season as the Super Bowl favorite with the moves they made, but they have had a really rocky start. They are barely .500 after the first month of the season and they are coming off a 24-20 win over the Eagles in their last one which they were trailing for most of the game and could have easily been 1-3 to start the year. The offense and the defense has been missing key players, but they also don't look like they are leagues above any of the elite teams in the NFL. The Bills just took their 1st loss of the season, losing at home to the Patriots 29-26, but that is a division rival who always gives them trouble. They still looked like one of the best teams in the NFL after 3 weeks and they will be looking to bounce back in this game. The Bills are a Super Bowl contender just like the Rams are, so the Bills aren't going to be intimidated here and they definitely have the talent to keep this game within a field goal if they don't win it outright. The best way to place a bet here is on the Bills to cover the spread in this game.
Bills Rams Prediction: Our NFL Pick for Monday, October 12, 2026 (8:15 pm ET start time) is Bills 34 Rams 30.
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NFL Betting Trends
Buffalo Bills: 1-6 ATS after a 2 game home stand. 3-6 ATS versus good defensive teams - allowing 285 yards/game or less. 2-5 ATS vs. good passing defenses - allowing 175 or less passing yards/game. 6-2 UNDER versus good offensive teams - averaging 5.65 yards/play or more. 6-2 UNDER versus good offensive teams - averaging 350 yards/game or more.
Los Angeles Rams: 8-3 ATS in non-conference games. 11-5 ATS when playing against a team with a winning record. 6-0 ATS vs. poor passing defenses - allowing 235 or more passing yards/game. 8-1 UNDER as a home favorite of 7 points or less. 8-2 UNDER versus poor defensive teams - allowing 5.65 yards/play or more.
Key Injuries
Buffalo Bills: D. Moore (WR) Injured - Shoulder. E. Oliver (DL) Injured - Knee. A. Reed-Adams (OG) Injured - Elbow. T. Sanders (DL) Injured - Illness. D. Williams (LB) Injured - Hip. D. Alford (CB) Injured - Ankle. J. Andreessen (LB) Injured - Knee. C. Benford (CB) Injured - Toe. T. Bernard (LB) Injured - Knee. B. Chubb (LB) Injured - Thumb. K. Coleman (WR) Injured - Ankle. R. Davis (RB) Injured - Hamstring. D. Hamlin (S) Injured - Rib. L. Jackson (DL) Injured - Knee.
Los Angeles Rams: K. Mumpfield (WR) Injured - Shoulder. J. Watson (CB) Injured - Shoulder. A. Donald (DL) Injured - Back. C. Parkinson (TE) Injured - Knee. G. Stuard (LB) Injured - Hamstring. J. Stewart (LB) Injured - Groin. Q. Lake (S) Injured - Hip. N. Landman (LB) Injured - Shoulder. D. Adams (WR) Injured - Rest.
Notable Quotes
“The wins and losses are all the same to me. I don’t mean that in a negative way. We’re not going to make excuses. We’re not gonna let others make excuses for us. Let’s just start with ourselves and then we’ll continue to clean it up and obviously start with myself.” - Joe Brady after his team’s loss against the Patriots in their last game.
“I think a lot of teams would have folded in those situations. I think our defense kept giving us a reason to believe.” - Sean McVay after his team’s win against the Eagles in their last game.
Starting Lineups
Buffalo Bills
WR Coleman, Keon
WR Moore, DJ
WR Shakir, Khalil
TE Kincaid, Dalton
QB Allen, Josh
RB Cook III, James
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Mumpfield, Konata
TE Higbee, Tyler
QB Stafford, Matthew
RB Williams, Kyren
Statistical Leaders
Buffalo Bills
Passing: Josh Allen (1,039)
Rushing: James Cook III (421)
Receiving: Dalton Kincaid (270)
Touchdowns: Josh Allen (7)
Los Angeles Rams
Passing: Matthew Stafford (1,189)
Rushing: Kyren Williams (294)
Receiving: Davante Adams (390)
Touchdowns: Kyren Williams (4)
Coaches:
Buffalo Bills: Joe Brady (1st season)
Los Angeles Rams: Sean McVay (10th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
