Buffalo Bills vs Cleveland Browns Prediction, Preview and Odds - 12/21/2025

Game Time: 1:00 pm ET, Sunday, December 21, 2025

Venue:  Huntington Bank Field, Cleveland, OH

Where to Watch:  CBS

DraftKings:  Point Spread:  Bills -10, Browns +10; Over/Under:  42.5 points

Bet365:  Point Spread:  Bills -10, Browns +10; Over/Under:  42 points

BetMGM:  Point Spread:  Bills -10, Browns +10; Over/Under:  42 points

Buffalo Bills:  10-4 (2nd place, AFC East)

Cleveland Browns:  3-11 (4th place, AFC North)

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Buffalo Bills:  won their last game on the road against the New England Patriots 35-31.

Cleveland Browns:  lost their last game on the road against the Chicago Bears 31-3.

The Bills are entering this game with a 10-4 record overall and they have a 3-2 record in their divisional games too. They are 6-1 in their home games, 4-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New England Patriots 35-31. Josh Allen was the starting QB and he completed 19/28 passes for 193 passing yards, 3 touchdowns, and 0 interceptions. James Cook led the team in rushing yards with 107 and 2 TDs. Khalil Shakir led the receivers with 65 receiving yards on 5 receptions. Matt Milano led the defense in that game with 9 solo tackles and 1 assisted tackle while Matt Milano led the defense in sacks with 2. Tre'Davious White came away with the only interception for them in that one.

 

 

 

The Browns are entering this game with a 3-11 record overall and they have a 0-4 record in their divisional games too. They are 2-4 in their home games, 1-6 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Chicago Bears 31-3. Shedeur Sanders was the starting QB and he completed 18/35 passes for 177 passing yards, 0 touchdowns, and 3 interceptions. Shedeur Sanders led the team in rushing yards with 24. Isaiah Bond led the receivers with 89 receiving yards on 2 receptions. Carson Schwesinger led the defense in that game with 4 solo tackles and 10 assisted tackles while Myles Garrett led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.

The current betting odds have the Bills listed as a 10 point favorite in this game according to Draftkings Sportsbook. The Bills have looked really good in their games this season with their 10-4 record overall which has them right near the top of the AFC East. They have been a good road team too with their 4-3 road record this year. Meanwhile, the Browns have looked terrible in their games this season with their 3-11 record overall which has them right at the bottom of the AFC North with one of the worst records in the NFL. They haven't looked great on their home field either with their 2-4 home record this year. The Browns are off a 31-3 loss to the Bears in their last one and after a hot start to the Shedeur Sanders era, they have reverted back to their old ways. Their offense hasn't looked great even with Shedeur, and the defense has been getting worse every week as the team has nothing left to play for in these games. The Bills are off a big win over the Patriots in their last one which has kept the division on the table for them so they have the momentum on their side now and have been rolling in their games lately. They don't have a great defense and that has been an issue for them all year, but they aren't facing a good offense here. The Bills also have one of the best offenses in the NFL at the moment, so this Browns defense is only going to be able to hold on for so long before the Bills pull away, and the Browns definitely don't have the offense to keep up. The best way to place a bet here is on the Bills to cover the spread in this game.

Bills Browns Prediction:  Our NFL Pick for Sunday, December 21, 2025 (1:00 pm ET start time) is Bills 31 Browns 10.

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Buffalo Bills: 1-6 ATS when playing against a terrible team (Win Pct. <=25%). 0-10 ATS vs. poor teams - outscored by 6+ points per game on the season. 1-7 ATS vs. poor offensive teams - scoring 17 or less points/game. 9-2 OVER off a win against a division rival. 

Cleveland Browns: 4-0 ATS as a home underdog of 7.5 to 14 points. 9-5 ATS at home after playing their last game on the road. 6-1 ATS at home versus good rushing teams - averaging 130 rushing yards/game or more. 10-5 OVER after a loss by 14 or more points.

Buffalo Bills:  None.

Cleveland Browns:  None.

“No matter what the score is, if it’s in the third quarter, in the fourth quarter, whatever it is, if we’ve got a chance and we’ve got the ball, we feel like we like our chances." - Josh Allen after their win against the Patriots in their last game. 

“He’s a young player that is making progress, like we’ve talked about all week. I see it in games. I get to see it in practice. There’s going to be ups and downs to young players, particularly the quarterback position. So we’ll learn from it, and we’ll be better next week.” - Kevin Stefanski after his team’s loss against the Bears in their last game. 

WR Shavers, Tyrell

WR Palmer, Joshua

WR Shakir, Khalil

TE Knox, Dawson

QB Allen, Josh

RB Cook, James

FB Gilliam, Reggie

WR Jeudy, Jerry

WR Tillman, Cedric

WR Bond, Isaiah

TE Fannin Jr., Harold

QB Sanders, Shedeur

RB Judkins, Quinshon

Passing: Josh Allen (3,276)

Rushing: James Cook (1,415)

Receiving: Khalil Shakir (650)

Touchdowns: Josh Allen (12)

Passing: Shedeur Sanders (946)

Rushing: Quinshon Judkins (805)

Receiving: Harold Fannin Jr. (667)

Touchdowns: Quinshon Judkins (7)

Coaches:

Buffalo Bills: Sean McDermott (9th season)

Cleveland Browns: Kevin Stefanski (6th season)