Buffalo Bills vs Carolina Panthers Prediction, Preview and Odds - 10/26/2025

Game Time: 1:00 pm ET, Sunday, October 26, 2025

Venue:  Bank of America Stadium, Charlotte, NC

Where to Watch:  FOX

DraftKings:  Point Spread:  Bills -7.5, Panthers +7.5; Over/Under:  45.5 points

Bet365:  Point Spread:  Bills -7.5, Panthers +7.5; Over/Under:  45.5 points

BetMGM:  Point Spread:  Bills -7.5, Panthers +7.5; Over/Under:  45.5 points

Buffalo Bills:  4-2 (2nd place, AFC East)

Carolina Panthers:  4-3 (2nd place, NFC South)

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Buffalo Bills:  lost their last game on the road against the Atlanta Falcons 24-14.

Carolina Panthers:  won their last game on the road against the New York Jets 13-6.

The Bills are entering this game with a 4-2 record overall and they have a 2-1 record in their divisional games too. They are 3-1 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Atlanta Falcons 24-14. Josh Allen was the starting QB and he completed 15/26 passes for 180 passing yards, 2 touchdowns, and 2 interceptions. James Cook led the team in rushing yards with 87. Josh Palmer led the receivers with 60 receiving yards on 2 receptions. Shaq Thompson led the defense in that game with 5 solo tackles and 5 assisted tackles while Ed Oliver and Javon Solomon each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Panthers are entering this game with a 4-3 record overall and they have a 1-0 record in their divisional games too. They are 3-0 in their home games, 1-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the New York Jets 13-6. Bryce Young was the starting QB and he completed 15/25 passes for 138 passing yards, 1 touchdown, and 0 interceptions. Rico Dowdle led the team in rushing yards with 79. Xavier Legette led the receivers with 92 receiving yards on 9 receptions and 1 TD. Derrick Brown led the defense in that game with 4 solo tackles and 3 assisted tackles while Derrick Brown led the defense in sacks with 2. Jaycee Horn came away with the only 2 interceptions for them in that one.

The current betting odds have the Bills listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. The Bills have looked good in their games this season with their 4-2 record overall which has them right near the top of the AFC East. They started the season 4-0 and were the hottest team in the NFL, but now they have lost 2 games in a row going into their bye week and the defense hasn't looked good in those losses. They have had 2 weeks now to figure things out though and they are going to come out of the bye week with some vigor now that the Patriots are becoming a real threat in their division. Meanwhile, the Panthers have looked good in their games this season with their 4-3 record overall which has them right near the top of the NFC South. They had a rough start to the season, but they have figured some things out now with 3 wins in a row. They are off a 13-6 win over the Jets in their last one and they have looked even better in their home games this year with their 3-0 home record, but Bryce Young looks like he is going to miss this game and that could have a huge impact on the team. Bryce Young wasn't lighting defenses up, but the offense was in a groove with him and that is going to change if Andy Dalton starts this game. The Panthers defense has looked better in their wins too, but they struggled against a better Cowboys offense even though they won that game and they are going to struggle with this Bills offense that is looking to bounce back with a better game. The best way to place a bet here is on the Bills to cover the spread in this game. 

Bills Panthers Prediction:  Our NFL Pick for Sunday, October 26, 2025 (1:00 pm ET start time) is Bills 31 Panthers 14.

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Buffalo Bills: 10-5 ATS when playing against a team with a winning record. 8-4 ATS versus good rushing teams - averaging 4.5 rushing yards/carry or more. 22-13 ATS after a bye week. 21-14 OVER in games played on turf. 

Carolina Panthers: 5-9 ATS in non-conference games. 2-8 ATS when playing against a team with a winning record. 5-9 ATS versus good offensive teams - averaging 5.65 yards/play or more. 5-1 OVER in a home game where the total is greater than or equal to 45.5. 4-0 OVER after a game with a turnover margin of +2 or better.

Buffalo Bills:  T. Bernard (LB) Injured - Ankle. M. Hairston (CB) Injured - Knee. D. Jones (DL) Injured - Calf. J. Palmer (WR) Injured - Knee. T. Rapp (S) Injured - Knee. C. Samuel (WR) Injured - Ribs. D. Kincaid (TE) Injured - Oblique. M. Milano (LB) Injured - Pectoral.

Carolina Panthers:  C. Jackson (DL) Injured - Illness. D. Wonnum (LB) Injured - NIR-Rest. D. Lewis (OG) Injured - Shoulder. J. Horn (CB) Injured - NIR-Rest. B. Young (QB) Injured - Ankle. P. Umanmielen (LB) Injured - Ribs.

“Blocking the kick I thought was big for us. Obviously, I thought we had some momentum coming out of that. So overall, opportunities, just not good enough and getting the result we want.” - Sean McDermott after his team’s loss against the Falcons in their last game. 

“We're evaluating him for the right ankle. So, we're taking all the information and we'll look at him when we get home some more and see where we're at.” - Dave Canales after his team’s win against the Jets in their last game. 

WR Shavers, Tyrell

WR Coleman, Keon

WR Shakir, Khalil

TE Knox, Dawson

QB Allen, Josh

RB Cook, James

FB Gilliam, Reggie

WR McMillan, Tetairoa

WR Legette, Xavier

WR Coker, Jalen

TE Sanders, Ja'Tavion

QB Dalton, Andy

RB Hubbard, Chuba

Passing: Josh Allen (1,397)

Rushing: James Cook (537)

Receiving: Dalton Kincaid (287)

Touchdowns: James Cook (5)

Passing: Bryce Young (1,288)

Rushing: Rico Dowdle (551)

Receiving: Tetairoa McMillan (413)

Touchdowns: Rico Dowdle (3)

Coaches:

Buffalo Bills: Sean McDermott (9th season)

Carolina Panthers: Dave Canales (2nd season)