Boston Red Sox vs Toronto Blue Jays Prediction, Preview and Odds - 09/25/2025

Game Time: 7:07 pm ET, Thursday, September 25, 2025

Venue:  Rogers Centre, Toronto, ON

Where to Watch:  NESN, Sportsnet

DraftKings:  Moneyline odds:  Red Sox +123, Blue Jays -150; Over/Under:  8 runs

Bet365:  Moneyline odds:  Red Sox +125, Blue Jays -150; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Red Sox +125, Blue Jays -150; Over/Under:  8 runs

Boston Red Sox:  86-71 (3rd place, AL East)

Toronto Blue Jays:  90-67 (1st place, AL East)

Do not miss out on our expert handicapper analysis! Jim Feist is on a HOT STREAK in the MLB on a 10-4 MLB RUN for +$5,740 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Boston Red Sox:  5-5 last 10

Toronto Blue Jays:  5-5 last 10

The Red Sox are entering this series off a loss and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with an 86-71 record overall and have a road record of 40-39. This is the series finale of a 3-game series with the Blue Jays on Thursday with the 2nd game still to be played on Wednesday. The Red Sox won the series opener on Tuesday. Their offense ranks 8th in the MLB with a .746 OPS. Garrett Crochet is their starting pitcher on Wednesday while Brayan Bello is making his start in this game on Thursday. He is 11-8 with a 3.34 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 1 HR, and 2 BB with 3 SO on 5 hits through 4 IP against the Athletics.

The Blue Jays are entering this series off a win and lost their 3-game series against the Kansas City Royals 2-1 in their last series. They enter this game with a 90-67 record overall and have a home record of 50-26. This is the 3rd game of a 3-game series with the Red Sox on Thursday with the 2nd game of this series still to be played on Wednesday. The Blue Jays lost the 1st game of this series on Tuesday. Their offense ranks 5th in the MLB with a .759 OPS. Max Scherzer is their starting pitcher on Wednesday while Shane Bieber is making his start in this game on Thursday. He is 3-2 with a 3.57 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 2 homers, and 1 walk with 4 strikeouts on 4 hits through 6.1 innings pitched against the Kansas City Royals.

The current betting odds have the Blue Jays listed as a favorite in this game according to Draftkings Sportsbook. The Blue Jays have looked great in their games this season with their 90-67 record overall which has them right at the top of the AL East with one of the best records in the MLB. They have also looked great in their own ballpark this year with their 50-26 home record. Meanwhile, the Red Sox have looked really good in their games this season with their 86-71 record overall which has them right in the middle of the AL East and in the Wild Card race. They haven't been a great road team though with their 40-39 road record this season. The Blue Jays have already clinched a playoff spot while the Red Sox are fighting for a Wild Card position, but the Blue Jays are still fighting to clinch the division and they have the better pitching matchup to take advantage of here. Bieber is on the mound for the Blue Jays in this one and he has looked good this season. He is 3-2 with a 3.57 ERA and hasn't been giving up many runs since returning from his injury. He is coming off a good start in which he gave up 2 earned runs and the team has had a lot of success with him lately too, winning 3 of the last 4 games that he started in. The Red Sox are going with Bello in this one and he has looked good this season too. He is 11-8 with a 3.34 ERA, but lately he has been giving up more runs in his starts. He just gave up 3 earned runs in his last start and the team has lost 2 games in a row now with him starting too. The Red Sox haven't had a great bullpen this season either. The best way to place a bet here is on the Blue Jays to win this game. 

Red Sox Blue Jays Prediction:  Our MLB Pick for Thursday, September 25, 2025 (7:07 pm ET start time) is Blue Jays 3 Red Sox 2.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Boston Red Sox Toronto Blue Jays prediction, be sure to drop by every day for our daily MLB projections and previews.

Boston Red Sox: 122-119 (+11.8 units) on the moneyline in road games. 95-112 (+9.2 units) on the moneyline as an underdog of +100 or higher. 79-74 (+9.6 units) on the moneyline against division opponents. 24-14 OVER on the road when playing against a team  with a winning record. 

Toronto Blue Jays: 253-230 (-10.7 units) on the moneyline in all games. 132-106 (-8.9 units) on the moneyline in home games. 148-122 (-26.5 units) on the moneyline as a favorite of -110 or higher. 28-20 OVER at home when the total is 8 to 8.5.

Boston Red Sox:  B. Bernardino (RP) Fifteen Day IL - Lat. V. Grissom (2B) Sixty Day IL - Foot. D. May (SP) Fifteen Day IL - Elbow. J. Hicks (RP) Fifteen Day IL - Shoulder. R. Anthony (RF) Ten Day IL - Oblique. M. Mayer (3B) Sixty Day IL - Wrist. R. Fitts (SP) Fifteen Day IL - Biceps. L. Guerrero (RP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Flexor. H. Dobbins (SP) Sixty Day IL - ACL. L. Hendriks (RP) Sixty Day IL - Hip. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. P. Sandoval (SP) Sixty Day IL - Elbow.

Toronto Blue Jays:  T. France (1B) Ten Day IL - Oblique. C. Bassitt (SP) Fifteen Day IL - Back. B. Bichette (SS) Ten Day IL - Knee. R. Pina (SP) Sixty Day IL - Elbow. N. Sandlin (RP) Sixty Day IL - Elbow. Y. Garcia (RP) Sixty Day IL - Ankle. B. Francis (SP) Sixty Day IL - Shoulder. R. Burr (RP) Sixty Day IL - Shoulder. A. Bastardo (SP) Sixty Day IL - Elbow.

“He’s been grinding, that’s part of it. The other day, it didn’t go his way, but this is a guy who has been there, done that, and has a World Series ring to show it and we trust him.” - Alex Cora after his team’s win against the Blue Jays in their game on Tuesday.

“We know it’s going to come down to the wire and we’ll continue to stay focused on what we have to do rather than anyone else. We’ve got another tough pitcher tomorrow in Crochet, so you’ve got to come ready and not say ‘woe is me’ about anything. Every game is going to be important.” - John Schneider after his team’s loss against the Red Sox in their game on Tuesday.

 

Jarren Duran (L) LF

Trevor Story (R) SS

Alex Bregman (R) 3B

Masataka Yoshida (L) DH

Romy Gonzalez (R) 2B

Ceddanne Rafaela (R) CF

Nathaniel Lowe (L) 1B

Wilyer Abreu (L) RF

Carlos Narváez (R) C

George Springer (R) LF

Ernie Clement (R) SS

Vladimir Guerrero Jr. (R) 1B

Alejandro Kirk (R) C

Anthony Santander (S) DH

Davis Schneider (R) 2B

Daulton Varsho (L) CF

Myles Straw (R) RF

Isiah Kiner-Falefa (R) 3B

Batting Average:  Romy Gonzalez (.308)

Hits:  Trevor Story (157)

Home Runs:  Trevor Story (25)

RBI:  Trevor Story (95)

Stolen Bases:  Trevor Story (31)

Wins:  Garrett Crochet (17)

Saves:  Aroldis Chapman (32)

ERA:  Nick Burdi (0.00)

Batting Average:  Joey Loperfido (.333)

Hits:  Bo Bichette (181)

Home Runs:  George Springer (30)

RBI:  Bo Bichette (94)

Stolen Bases:  George Springer (16)

Wins:  Chris Bassitt (11)

Saves:  Jeff Hoffman (32)

ERA:  Ryan Burr (0.00)

Managers:

Boston Red Sox: Álex Cora (5th season)

Toronto Blue Jays: John Schneider (4th season)