Boston Red Sox vs Toronto Blue Jays Prediction, Preview and Odds - 09/24/2025

Game Time: 7:07 pm ET, Wednesday, September 24, 2025

Venue:  Rogers Centre, Toronto, ON

Where to Watch:  NESN, Sportsnet

DraftKings:  Moneyline odds:  Red Sox -144, Blue Jays +118; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Red Sox -145, Blue Jays +120; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Red Sox -145, Blue Jays +120; Over/Under:  8 runs

Boston Red Sox:  85-71 (3rd place, AL East)

Toronto Blue Jays:  90-66 (1st place, AL East)

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Boston Red Sox:  4-6 last 10

Toronto Blue Jays:  6-4 last 10

The Red Sox are entering this series off a loss and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with an 85-71 record overall and have a road record of 39-39. This is the 2nd game of a 3-game series with the Blue Jays on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 8th in the MLB with a .748 OPS. Lucas Giolito is their starting pitcher on Tuesday while Garrett Crochet is making his start in this game on Wednesday. He is 17-5 with a 2.69 ERA this season. His team won their last 6 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 2 HR, and 3 BB with 9 SO on 4 hits through 6 IP against the Tampa Bay Rays.

The Blue Jays are entering this series off a win and lost their 3-game series against the Kansas City Royals 2-1 in their last series. They enter this game with a 90-66 record overall and have a home record of 50-25. This is the 2nd game of a 3-game series with the Red Sox on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 3rd in the MLB with a .761 OPS. Kevin Gausman is their starting pitcher on Tuesday while Max Scherzer is making his start in this game on Wednesday. He is 5-4 with a 5.06 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 7 earned runs, 2 homers, and 1 walk with 2 strikeouts on 7 hits through 0.2 innings pitched against the Kansas City Royals.

The current betting odds have the Red Sox listed as a favorite in this game according to Draftkings Sportsbook. The Blue Jays have looked great in their games this season with their 90-66 record overall which has them right at the top of the AL East with one of the best records in the MLB. They have also looked great in their own ballpark this year with their 50-25 home record. Meanwhile, the Red Sox have looked really good in their games this season with their 85-71 record overall which has them right in the middle of the AL East and in the Wild Card race. They haven't been a great road team though with their 39-39 road record this season. The Red Sox haven't looked great lately either, but they are still fighting for a playoff spot and they have the better pitching matchup in this one so they will be looking to take advantage of that. The Red Sox are going with Crochet in this one and he has looked great all season. He is 17-5 with a 2.69 ERA and has been their best starter this year. He did give up 3 earned runs in his last start, but that hasn't been a common theme for him this year and the team has still had a ton of success with him, winning 6 games in a row now with him as the starter. The Blue Jays are going with Scherzer in this one and he hasn't looked great this season. He is 5-4 with a 5.06 ERA and he has been giving up quite a few runs lately. He is coming off another bad start in which he gave up 7 earned runs and the team has been struggling with him too, losing 2 of their last 3 games with him starting. The Blue Jays haven't won the division yet, but they have clinched a playoff spot while the Red Sox are holding onto a Wild Card spot in a tight race and need this game more. The best way to place a bet here is on the Red Sox to win this game. 

Red Sox Blue Jays Prediction:  Our MLB Pick for Wednesday, September 24, 2025 (7:07 pm ET start time) is Red Sox 5 Blue Jays 2.

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Boston Red Sox: 121-119 (+10.4 units) on the moneyline in road games. 47-32 (+9 units) on the moneyline on the road with a money line of -100 to -150. 78-74 (+8.2 units) on the moneyline against division opponents. 26-19 OVER as a road favorite of -125 or more.

Toronto Blue Jays: 253-229 (-9.2 units) on the moneyline in all games. 132-105 (-7.4 units) on the moneyline in home games. 124-128 (-7 units) on the moneyline when the money line is +125 to -125. 30-17 OVER as a home underdog of +100 or higher. 

Boston Red Sox:  B. Bernardino (RP) Fifteen Day IL - Lat. V. Grissom (2B) Sixty Day IL - Foot. D. May (SP) Fifteen Day IL - Elbow. J. Hicks (RP) Fifteen Day IL - Shoulder. R. Anthony (RF) Ten Day IL - Oblique. M. Mayer (3B) Sixty Day IL - Wrist. R. Fitts (SP) Fifteen Day IL - Biceps. L. Guerrero (RP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Flexor. H. Dobbins (SP) Sixty Day IL - ACL. L. Hendriks (RP) Sixty Day IL - Hip. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. P. Sandoval (SP) Sixty Day IL - Elbow.

Toronto Blue Jays:  C. Bassitt (SP) Fifteen Day IL - Back. B. Bichette (SS) Ten Day IL - Knee. R. Pina (SP) Sixty Day IL - Elbow. N. Sandlin (RP) Sixty Day IL - Elbow. Y. Garcia (RP) Sixty Day IL - Ankle. B. Francis (SP) Sixty Day IL - Shoulder. R. Burr (RP) Sixty Day IL - Shoulder. A. Santander (RF) Sixty Day IL - Shoulder. A. Bastardo (SP) Sixty Day IL - Elbow.

“Every game counts. We're in a good position. That was a good series by the boys. They battled. They did an amazing job, and we’ve just got to be ready for Tuesday.” - Alex Cora after his team’s loss against the Rays in their game on Sunday.

“I’m so happy for them. It’s hard at this level for everyone to put their egos aside and play for one another. It’s so cool to see them genuinely happy for one another when they get the job done, no matter who it is. This is the most fulfilling team I’ve ever been a part of.” - John Schneider after his team clinched a playoff spot.

 

Jarren Duran (L) LF

Trevor Story (R) SS

Alex Bregman (R) 3B

Masataka Yoshida (L) RF

Romy Gonzalez (R) 2B

Nathaniel Lowe (L) 1B

Ceddanne Rafaela (R) CF

Wilyer Abreu (L) DH

Connor Wong (R) C

George Springer (R) DH

Daulton Varsho (L) CF

Vladimir Guerrero Jr. (R) 1B

Addison Barger (L) 3B

Davis Schneider (R) LF

Nathan Lukes (L) RF

Ernie Clement (R) 2B

Andrés Giménez (L) SS

Tyler Heineman (S) C

Batting Average:  Romy Gonzalez (.308)

Hits:  Jarren Duran (156)

Home Runs:  Trevor Story (25)

RBI:  Trevor Story (95)

Stolen Bases:  Trevor Story (31)

Wins:  Garrett Crochet (17)

Saves:  Aroldis Chapman (31)

ERA:  Nick Burdi (0.00)

Batting Average:  Joey Loperfido (.337)

Hits:  Bo Bichette (181)

Home Runs:  George Springer (30)

RBI:  Bo Bichette (94)

Stolen Bases:  George Springer (16)

Wins:  Chris Bassitt (11)

Saves:  Jeff Hoffman (32)

ERA:  Ryan Burr (0.00)

Managers:

Boston Red Sox: Álex Cora (5th season)

Toronto Blue Jays: John Schneider (4th season)