Boston Red Sox vs Toronto Blue Jays Prediction, Preview and Odds - 09/23/2025

Game Time: 7:07 pm ET, Tuesday, September 23, 2025

Venue:  Rogers Centre, Toronto, ON

Where to Watch:  NESN, Sportsnet

DraftKings:  Moneyline odds:  Red Sox +134, Blue Jays -164; Over/Under:  8 runs

Bet365:  Moneyline odds:  Red Sox +140, Blue Jays -170; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Red Sox +140, Blue Jays -165; Over/Under:  8 runs

Boston Red Sox:  85-71 (3rd place, AL East)

Toronto Blue Jays:  90-66 (1st place, AL East)

Do not miss out on our expert handicapper analysis! Jim Feist is on a HOT STREAK in the MLB on an 11-4 MLB RUN for +$7,090 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Boston Red Sox:  4-6 last 10

Toronto Blue Jays:  6-4 last 10

The Red Sox are entering this series off a loss and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with an 85-71 record overall and have a road record of 39-39. This is the series opener of a 3-game series with the Blue Jays on Tuesday and they have Monday off as a day of rest. Their offense ranks 8th in the MLB with a .748 OPS. Rookie pitcher Connelly Early was their starting pitcher on Sunday while Lucas Giolito is making his start in this game on Tuesday. He is 10-4 with a 3.46 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 ER, 0 HR, and 5 BB with 5 SO on 5 hits through 4.1 IP against the Athletics.

The Blue Jays are entering this series off a win and lost their 3-game series against the Kansas City Royals 2-1 in their last series. They enter this game with a 90-66 record overall and have a home record of 50-25. This is the 1st game of a 3-game series with the Red Sox on Tuesday and they have Monday off as a day of rest. Their offense ranks 3rd in the MLB with a .761 OPS. Rookie pitcher Trey Yesavage was their starting pitcher on Sunday while Kevin Gausman is making his start in this game on Tuesday. He is 10-10 with a 3.38 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 2 walks with 6 strikeouts on 6 hits through 6 innings pitched against the Tampa Bay Rays.

The current betting odds have the Blue Jays listed as a favorite in this game according to Draftkings Sportsbook. The Blue Jays have looked great in their games this season with their 90-66 record overall which has them right at the top of the AL East with one of the best records in the MLB. They have also looked great in their own ballpark this year with their 50-25 home record. Meanwhile, the Red Sox have looked really good in their games this season with their 85-71 record overall which has them right in the middle of the AL East and in the Wild Card race. They haven't been a great road team though with their 39-39 road record this season. They haven't looked great lately either, going 4-6 in their last 10 games while the Blue Jays are 6-4, and the Blue Jays are still looking to clinch the division so this is a big series for them to stay ahead of the Yankees. The Blue Jays are going with Gausman in this one and he has looked good this season. He is 10-10 with a 3.38 ERA and he hasn't been giving up many runs lately. He is coming off another good start in which he gave up 1 earned run and the team has won 2 of their last 3 games with him starting too. The Red Sox are going with Giolito in this one and he has looked great this season. He is 10-4 with a 3.46 ERA, but lately he has been giving up a lot more runs. He is coming off another bad start in which he gave up 4 earned runs, and the team has been struggling with him lately too, losing 2 of their last 3 games with him starting. All signs are pointing to the Blue Jays to stay hot in this one. The best way to place a bet here is on the Blue Jays to win this game. 

Red Sox Blue Jays Prediction:  Our MLB Pick for Tuesday, September 23, 2025 (7:07 pm ET start time) is Blue Jays 6 Red Sox 3.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Boston Red Sox Toronto Blue Jays prediction, be sure to drop by every day for our daily MLB projections and previews.

Boston Red Sox: 121-119 (+10.4 units) on the moneyline in road games. 94-112 (+7.8 units) on the moneyline as an underdog of +100 or higher. 78-74 (+8.2 units) on the moneyline against division opponents. 17-10 OVER as a road underdog of +100 to +150.

Toronto Blue Jays: 253-229 (-9.2 units) on the moneyline in all games. 132-105 (-7.4 units) on the moneyline in home games. 148-121 (-25 units) on the moneyline as a favorite of -110 or higher. 28-19 OVER at home when the total is 8 to 8.5. 

Boston Red Sox:  B. Bernardino (RP) Fifteen Day IL - Lat. V. Grissom (2B) Sixty Day IL - Foot. D. May (SP) Fifteen Day IL - Elbow. J. Hicks (RP) Fifteen Day IL - Shoulder. R. Anthony (RF) Ten Day IL - Oblique. M. Mayer (3B) Sixty Day IL - Wrist. R. Fitts (SP) Fifteen Day IL - Biceps. L. Guerrero (RP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Flexor. H. Dobbins (SP) Sixty Day IL - ACL. L. Hendriks (RP) Sixty Day IL - Hip. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. P. Sandoval (SP) Sixty Day IL - Elbow.

Toronto Blue Jays:  C. Bassitt (SP) Fifteen Day IL - Back. B. Bichette (SS) Ten Day IL - Knee. R. Pina (SP) Sixty Day IL - Elbow. N. Sandlin (RP) Sixty Day IL - Elbow. Y. Garcia (RP) Sixty Day IL - Ankle. B. Francis (SP) Sixty Day IL - Shoulder. R. Burr (RP) Sixty Day IL - Shoulder. A. Santander (RF) Sixty Day IL - Shoulder. A. Bastardo (SP) Sixty Day IL - Elbow.

“Every game counts. We're in a good position. That was a good series by the boys. They battled. They did an amazing job, and we’ve just got to be ready for Tuesday.” - Alex Cora after his team’s loss against the Rays in their game on Sunday.

“I’m so happy for them. It’s hard at this level for everyone to put their egos aside and play for one another. It’s so cool to see them genuinely happy for one another when they get the job done, no matter who it is. This is the most fulfilling team I’ve ever been a part of.” - John Schneider after his team clinched a playoff spot.

 

Jarren Duran (L) LF

Trevor Story (R) SS

Alex Bregman (R) 3B

Masataka Yoshida (L) RF

Romy Gonzalez (R) 2B

Nathaniel Lowe (L) 1B

Ceddanne Rafaela (R) CF

Wilyer Abreu (L) DH

Connor Wong (R) C

George Springer (R) DH

Daulton Varsho (L) CF

Vladimir Guerrero Jr. (R) 1B

Addison Barger (L) 3B

Davis Schneider (R) LF

Nathan Lukes (L) RF

Ernie Clement (R) 2B

Andrés Giménez (L) SS

Tyler Heineman (S) C

Batting Average:  Romy Gonzalez (.308)

Hits:  Jarren Duran (156)

Home Runs:  Trevor Story (25)

RBI:  Trevor Story (95)

Stolen Bases:  Trevor Story (31)

Wins:  Garrett Crochet (17)

Saves:  Aroldis Chapman (31)

ERA:  Nick Burdi (0.00)

Batting Average:  Joey Loperfido (.337)

Hits:  Bo Bichette (181)

Home Runs:  George Springer (30)

RBI:  Bo Bichette (94)

Stolen Bases:  George Springer (16)

Wins:  Chris Bassitt (11)

Saves:  Jeff Hoffman (32)

ERA:  Ryan Burr (0.00)

Managers:

Boston Red Sox: Álex Cora (5th season)

Toronto Blue Jays: John Schneider (4th season)