Boston Red Sox vs New York Yankees Prediction, Preview and Odds - 08/22/2025

Game Time: 7:05 pm ET, Friday, August 22, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLBN, Prime Video

DraftKings:  Moneyline odds:  Red Sox +140, Yankees -172; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Red Sox +140, Yankees -170; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Red Sox +140, Yankees -170; Over/Under:  8.5 runs

Boston Red Sox:  68-59 (3rd place, AL East)

New York Yankees:  69-57 (2nd place, AL East)

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Boston Red Sox:  3-7 last 10

New York Yankees:  8-2 last 10

The Red Sox are entering this series off a loss and got swept in their 2-game series against the Baltimore Orioles 2-0 in their last series. They enter this game with a 68-59 record overall and have a road record of 27-34. This is the 2nd game of a 4-game series with the Yankees on Friday with the series opener still to be played on Thursday. Their offense ranks 7th in the MLB with a .748 OPS. Lucas Giolito is their starting pitcher on Thursday while Brayan Bello is making his start in this game on Friday. He is 9-6 with a 3.23 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 2 HR, and 0 BB with 2 SO on 4 hits through 6.1 IP against the Miami Marlins.

The Yankees are entering this series off a win and completed the sweep in their 2-game series against the Tampa Bay Rays 2-0. They enter this game with a 69-57 record overall and have a home record of 37-25. This is the 2nd game of a 4-game series with the Red Sox on Friday with the 1st game of this series still to be played on Thursday. Their offense ranks 1st in the MLB with a .785 OPS. Luis Gil is their starting pitcher on Thursday while Max Fried is making his start in this game on Friday. He is 13-5 with a 3.26 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 7 earned runs, 2 homers, and 1 walk with 6 strikeouts on 8 hits through 5 innings pitched against the St Louis Cardinals.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Red Sox have looked good in their games this season with their 68-59 record overall which has them right in the middle of the AL East. They haven't been a great road team though with their 27-34 road record this year. Meanwhile, the Yankees have looked good in their games this season with their 69-57 record overall which has them right near the top of the AL East. They have also looked great in their own ballpark this year with their 37-25 home record. The Yankees just passed the Red Sox in the division and they have been starting to get really hot again. The Yankees are now 8-2 in their last 10 games while the Red Sox are 3-7 in their last 10 and are starting to slump again. The Red Sox will have Bello on the mound here and he has looked good this season. He is 9-6 with a 3.23 ERA and the team has been having success with him lately. They have won 3 of their last 4 games with him starting and he only gave up 2 earned runs in his last start too. The Yankees are also going to have a solid starter though as they are going with Fried in this one. He is 13-5 with a 3.26 ERA and has been one of their best starters all season. He did give up 7 earned runs in his last start and the team has lost 2 of their last 3 games with him starting now, but that hasn't been a common theme for him this year and he will be looking to bounce back with a better start at home. The Red Sox do have a great offense, but they haven't been putting up a ton of runs lately while the Yankees also have one of the best offenses in the MLB and have been rolling again lately. The best way to place a bet here is on the Yankees to win this game. 

Red Sox Yankees Prediction:  Our MLB Pick for Friday, August 22, 2025 (7:05 pm ET start time) is Yankees 4 Red Sox 2.

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Boston Red Sox: 90-109 (+5.6 units) on the moneyline as an underdog of +100 or higher. 56-52 (+9.1 units) on the moneyline on the road when the total is 8 to 8.5. 166-161 (+7.9 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 16-8 OVER vs. a starting pitcher whose winning percentage is better than 70%.

New York Yankees: 252-211 (-28.4 units) on the moneyline in all games. 127-104 (-28.3 units) on the moneyline in home games. 188-148 (-40.9 units) on the moneyline as a favorite of -110 or higher. 4-1 OVER at home vs. poor fielding teams - averaging 0.75+ errors/game.

Boston Red Sox:  W. Abreu (RF) Day To Day - Calf. R. Refsnyder (RF) Ten Day IL - Oblique. L. Guerrero (RP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Flexor. H. Dobbins (SP) Sixty Day IL - ACL. M. Mayer (3B) Ten Day IL - Wrist. L. Hendriks (RP) Sixty Day IL - Hip. J. Slaten (RP) Sixty Day IL - Shoulder. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. P. Sandoval (SP) Sixty Day IL - Elbow.

New York Yankees:  B. Headrick (RP) Fifteen Day IL - Forearm. A. Slater (LF) Ten Day IL - Hamstring. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. F. Cruz (RP) Fifteen Day IL - Oblique. R. Yarbrough (SP) Fifteen Day IL - Oblique. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

“Yeah, we chased a lot today. We haven't done that in a while. We had our opportunities to win the game early in the game, in the middle of the game, late in the game. It just didn’t happen.” - Alex Cora after his team’s loss against the Orioles in their game on Tuesday.

"He’s so good at the mental game now, preparing and knowing how to do it. He has tremendous self-awareness of who he is as a hitter now. He’s an animal.” - Aaron Boone after his team’s win against the Rays in their game on Wednesday.

Nate Eaton (R) DH

Roman Anthony (L) RF

Alex Bregman (R) 3B

Romy Gonzalez (R) 2B

Trevor Story (R) SS

Jarren Duran (L) LF

Ceddanne Rafaela (R) CF

Carlos Narváez (R) C

Abraham Toro (S) 1B

Trent Grisham (L) CF

Ben Rice (L) 1B

Aaron Judge (R) DH

Cody Bellinger (L) RF

Jazz Chisholm Jr. (L) 2B

Jasson Domínguez (S) LF

Anthony Volpe (R) SS

Ryan McMahon (L) 3B

Austin Wells (L) C

Batting Average:  Alex Bregman (.298)

Hits:  Jarren Duran (129)

Home Runs:  Wilyer Abreu (22)

RBI:  Trevor Story (79)

Stolen Bases:  Trevor Story (22)

Wins:  Garrett Crochet (13)

Saves:  Aroldis Chapman (22)

ERA:  Nick Burdi (0.00)

Batting Average:  Amed Rosario (.500)

Hits:  Aaron Judge (139)

Home Runs:  Aaron Judge (40)

RBI:  Aaron Judge (92)

Stolen Bases:  Jazz Chisholm (21)

Wins:  Max Fried (13)

Saves:  Devin Williams (18)

ERA:  Adam Ottavino (0.00)

Managers:

Boston Red Sox: Álex Cora (5th season)

New York Yankees: Aaron Boone (8th season)