Boston Red Sox vs Houston Astros Prediction, Preview and Odds - 08/13/2025

Game Time: 7:10 pm ET, Wednesday, August 13, 2025

Venue:  Daikin Park, Houston, TX

Where to Watch:  NESN, SCHN

DraftKings:  Moneyline odds:  Red Sox +144, Astros -176; Over/Under:  8 runs

Bet365:  Moneyline odds:  Red Sox +145, Astros -175; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Red Sox +145, Astros -175; Over/Under:  8 runs

Boston Red Sox:  65-55 (2nd place, AL East)

Houston Astros:  67-52 (1st place, AL West)

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Boston Red Sox:  6-4 last 10

Houston Astros:  5-5 last 10

The Red Sox are entering this series off a loss and lost their 3-game series against the San Diego Padres 2-1 in their last series. They enter this game with a 65-55 record overall and have a road record of 26-33. This is the series finale of a 3-game series with the Astros on Wednesday with the 2nd game still to be played on Tuesday. The Red Sox lost the series opener on Monday. Their offense ranks 6th in the MLB with a .753 OPS. Dustin May is their starting pitcher on Tuesday while Walker Buehler is making his start in this game on Wednesday. He is 7-6 with a 5.40 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 2 BB with 4 SO on 4 hits through 6 IP against the San Diego Padres.

The Astros are entering this series off a win and won their 3-game series against the New York Yankees 2-1 in their last series. They enter this game with a 67-52 record overall and have a home record of 36-24. This is the 3rd game of a 3-game series with the Red Sox on Wednesday with the 2nd game of this series still to be played on Tuesday. The Astros won the 1st game of this series on Monday. Their offense ranks 10th in the MLB with a .733 OPS. Spencer Arrighetti is their starting pitcher on Tuesday while Hunter Brown is making his start in this game on Wednesday. He is 9-5 with a 2.51 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 1 walk with 5 strikeouts on 4 hits through 5.1 innings pitched against the New York Yankees.

The current betting odds have the Astros listed as a favorite in this game according to Draftkings Sportsbook. The Red Sox have looked really good in their games this season with their 65-55 record overall which has them right near the top of the AL East. They haven't been a good road team though with their 26-33 road record this year. Meanwhile, the Astros have looked great in their games this season with their 67-52 record overall which has them right at the top of the AL West. They have also looked great in their own ballpark this year with their 36-24 home record. The Red Sox are 6-4 in their last 10 games and have been the hotter team lately, but not by much and the Astros already took the 1st game of this series. The Astros also have the better pitching matchup in this one and they can take advantage of that at home where they have looked a lot better this year. Brown is on the mound for the Astros in this one and he has been one of their best starters this season. He is 9-5 with a 2.51 ERA and he hasn't been giving up many runs lately. The team has lost 2 of their last 3 games with him starting, but he is coming off another good start in which he only gave up 2 earned runs and that has been a common theme for him. The Red Sox are going with Buehler in this one and he hasn't looked great this year. He is 7-6 with a 5.40 ERA and has been giving up quite a few runs in his starts, especially in his road starts. His team has won 3 games in a row now with him starting and he is coming off a great start in which he gave up no runs, but that hasn't been a common theme for him this year and he will struggle more on the road against this better offense. The best way to place a bet here is on the Astros to win this game. 

Red Sox Astros Prediction:  Our MLB Pick for Wednesday, August 13, 2025 (7:10 pm ET start time) is Astros 6 Red Sox 1.

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Boston Red Sox: 223-220 (-13.3 units) on the moneyline in all games. 61-70 (-5.4 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 164-161 (-10.1 units) on the moneyline against right-handed starters. 31-21 OVER on the road vs. a team with a good bullpen whose ERA is 3.45 or better.

Houston Astros: 47-32 (+11.8 units) on the moneyline vs. AL teams scoring 4.9 or more runs/game on the season. 59-46 (+8.9 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 82-63 (+13.9 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 48-28 OVER vs. AL teams scoring 4.9 or more runs/game on the season.

Boston Red Sox:  L. Guerrero (RP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Flexor. H. Dobbins (SP) Sixty Day IL - ACL. M. Mayer (3B) Ten Day IL - Wrist. L. Hendriks (RP) Sixty Day IL - Hip. J. Slaten (RP) Sixty Day IL - Shoulder. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. P. Sandoval (SP) Sixty Day IL - Elbow.

Houston Astros:  I. Paredes (3B) Sixty Day IL - Hamstring. B. Walter (RP) Fifteen Day IL - Elbow. L. McCullers Jr. (SP) Fifteen Day IL - Finger. B. Rodgers (2B) Sixty Day IL - Oblique. J. Meyers (CF) Ten Day IL - Calf. Z. Dezenzo (RF) Sixty Day IL - Hand. Y. Alvarez (LF) Sixty Day IL - Hand. S. Dubin (RP) Fifteen Day IL - Forearm. P. Leon (RF) Sixty Day IL - Knee. R. Blanco (SP) Sixty Day IL - Elbow. H. Wesneski (RP) Sixty Day IL - Elbow. L. Garcia (SP) Sixty Day IL - Elbow. J. France (SP) Sixty Day IL - Shoulder.

“Obviously, my worst [start] since I’ve worn the Red Sox uniform, so it’s tough. Just had trouble putting guys away or getting them to put the ball in play early in the count.” - Garrett Crochet after their loss against the Astros in their game on Monday.

“He walked in today and he was doing his [plyometrics] before doing his throwing program and just did not feel right. We went ahead and got some testing done, and we’re waiting on the results and should know something more tomorrow.” - Joe Espada after his team’s win against the Red Sox in their game on Monday.

Roman Anthony (L) DH

Alex Bregman (R) 3B

Jarren Duran (L) LF

Trevor Story (R) SS

Wilyer Abreu (L) RF

Romy Gonzalez (R) 2B

Abraham Toro (S) 1B

Ceddanne Rafaela (R) CF

Carlos Narváez (R) C

Jeremy Peña (R) SS

Carlos Correa (R) 3B

Jose Altuve (R) DH

Christian Walker (R) 1B

Yainer Diaz (R) C

Ramón Urías (R) 2B

Mauricio Dubón (R) LF

Chas McCormick (R) CF

Cam Smith (R) RF

Batting Average:  Alex Bregman (.301)

Hits:  Jarren Duran (125)

Home Runs:  Wilyer Abreu (21)

RBI:  Trevor Story (73)

Stolen Bases:  Trevor Story (19)

Wins:  Garrett Crochet (13)

Saves:  Aroldis Chapman (21)

ERA:  Nick Burdi (0.00)

Batting Average:  Carlos Correa (.390)

Hits:  Jose Altuve (127)

Home Runs:  Jose Altuve (21)

RBI:  Christian Walker (65)

Stolen Bases:  Jeremy Peña (16)

Wins:  Framber Valdez (11)

Saves:  Josh Hader (28)

ERA:  Enyel De Los Santos (0.00)

Managers:

Boston Red Sox: Álex Cora (5th season)

Houston Astros: Joe Espada (2nd season)