Boston College Eagles vs Louisville Cardinals Prediction, Picks and Game Preview - 10/25/2025

Game Time: 7:30 pm ET, Saturday, October 25, 2025

Venue:  L&N Federal Credit Union Stadium, Louisville, KY

Where to Watch:  ACC Network

DraftKings:  Point Spread:  Boston College +25.5, Louisville -25.5; Over/Under:  55.5 points

Bet365:  Point Spread:  Boston College +25.5, Louisville -25.5; Over/Under:  55.5 points

BetMGM:  Point Spread:  Boston College +25.5, Louisville -25.5; Over/Under:  55.5 points

Boston College Eagles:  1-6 (0-4) (17th place, ACC)

Louisville Cardinals:  5-1 (2-1) (6th place, ACC)

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Boston College Eagles:  lost their last game at home against the UConn Huskies 38-23.

Louisville Cardinals:  won their last game on the road against the Miami Hurricanes 24-21.

Boston College is entering this game with a 1-6 record overall and they have a 0-4 record in their conference games too. They are 1-3 in their home games, 0-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against UConn 38-23. Grayson James was the starting QB and he completed 16/28 passes for 204 passing yards, 2 touchdowns, and 0 interceptions. Jordan McDonald led the team in rushing yards with 123. Lewis Bond led the receivers with 69 receiving yards on 5 receptions. Omar Thornton led the defense in that game with 10 solo tackles and 0 assisted tackles while Sed McConnell and Chris Marable Jr. each led the defense in sacks with 0.5. No one on the defense came away with an interception for them in that one.

 

 

 

Louisville is entering this game with a 5-1 record overall and they have a 2-1 record in their conference games too. They are 3-1 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Miami-FL 24-21. Miller Moss was the starting QB and he completed 23/37 passes for 248 passing yards, 2 touchdowns, and 0 interceptions. Isaac Brown led the team in rushing yards with 113. Chris Bell led the receivers with 136 receiving yards on 9 receptions and 2 TDs. TJ Quinn led the defense in that game with 4 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. JoJo Evans, Jabari Mack, Antonio Watts, and T.J. Capers each came away with 1 interception for them in that one.

The current betting odds have Louisville listed as a 25.5 point favorite in this game according to Draftkings Sportsbook. Louisville has looked really good in their games this season with their 5-1 record overall and their 2-1 conference record which has them right near the top of the ACC. Their only loss this season was against Virginia, but that loss has been aging well. Now they are off a huge upset win over Miami on the road in their last one and they are going to have a ton of momentum from that win. They looked great in that game too as they were leading the entire time. Meanwhile, Boston College has looked terrible in their games this season with their 1-6 record overall and their 0-4 conference record which has them right at the bottom of the ACC. They have been getting blown out in a lot of games lately and they are off a 38-23 loss to UConn in their last one. Their defense has looked terrible all season with the number of points they have been giving up in their games and their offense hasn't been doing much in their games lately either. Louisville has a really good offense that is going to put up a ton of points on this BC defense and they are playing with the momentum from that Miami win. This is also the first time all season that Louisville has been ranked inside the top 25 so they will be fighting to keep that ranking with a big win over the worst team in the conference. The best way to place a bet here is on Louisville to cover the spread in this game. 

Boston College Louisville Prediction:  Our NCAAF Pick for Saturday, October 25, 2025 (7:30 pm ET start time) is Louisville 38 Boston College 10.

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Boston College Eagles: 1-6 ATS versus poor rushing teams - averaging 120 rushing yards/game or less. 3-6 ATS versus good rushing defenses - allowing 120 rushing yards/game or less. 5-9 ATS vs. good passing teams averaging 250 or more passing yards/game. 11-6 OVER when the total is between 49.5 and 56. 12-6 OVER against conference opponents.

Louisville Cardinals: 8-4 ATS as a home favorite of 21.5 to 28 points. 30-19 ATS in a home game where the total is between 49.5 and 56. 11-5 OVER when the total is between 49.5 and 56. 5-0 OVER when playing against a team with a losing record.

Boston College Eagles:  O. Stoudmire (DL) Questionable - Undisclosed. C. Martinez (CB) Questionable - Undisclosed. D. Crouch (LB) Questionable - Undisclosed. J. Skeete (WR) Questionable - Undisclosed. S. Sanders (DL) Questionable - Undisclosed. M. Townsend (CB) Questionable - Undisclosed. P. Faoa (LB) Questionable - Undisclosed. D. Edgehille (TE) Questionable - Undisclosed. A. Jackson (CB) Questionable - Leg. S. Torrence (CB) Questionable - Undisclosed. J. Blackwell (LB) Questionable - Undisclosed. W. Graves III (WR) Questionable - Undisclosed. J. Montague Jr. (WR) Out - Knee.

Louisville Cardinals:  T. Folmar (OG) Questionable - Undisclosed. J. Wilder (RB) Questionable - Undisclosed. S. Gates (RB) Questionable - Undisclosed. D. Watson (RB) Questionable - Undisclosed. T. Egan (QB) Questionable - Undisclosed. N. Jackson (OG) Questionable - Undisclosed. M. Pounders (OG) Questionable - Undisclosed. S. Clark (LB) Out - Ankle.

“I’m very confident. I think this is a place where you can win in football. People have asked why have we regressed, there’s several factors. I’ve told you after every game we haven’t coached as well as we did last year. There’s some guys that were on our team last year that are playing on Sunday’s now. There’s some young players here that have had to play right away. These aren’t excuses. It is what it is. I think recruiting’s going really well. BC’s making a commitment to football here which I think is big and there’s a future. “ - Bill O’Brien on the direction of the program.

“This is what college football is all about. Every week is going to be a contest down to the very end, no matter who you play.” - Jeff Brohm after his team’s win against Miami-Florida in their last game. 

WR Harris, Reed

WR Pough, Dawson

WR Bond, Lewis

TE Franklin, Jeremiah

QB Lonergan, Dylan

RB Richard, Turbo

WR Hurry, TreyShun

WR Bell, Chris

WR Lacy, Caullin

TE Kurisky, Nate

QB Moss, Miller

RB Brown, Isaac

Passing: Dylan Lonergan (1,394)

Rushing: Turbo Richard (431)

Receiving: Lewis Bond (505)

Touchdowns: Turbo Richard (7)

Passing: Miller Moss (1,606)

Rushing: Isaac Brown (447)

Receiving: Chris Bell (638)

Touchdowns: Chris Bell (6)

Coaches:

Boston College Eagles: Bill O'Brien (2nd season)

Louisville Cardinals: Jeff Brohm (3rd season)