Big Al's Daily Angle: NFL, NCAAF, MLB and UEFA Champions League Previews and Odds - 09/18/2025

by Big Al Staff

Thursday, Sep 18, 2025
The Thursday sports card features NFL, NCAAF, MLB, and UEFA Champions League action. 

Week 3 in the National Football League kicks off with one game. The Buffalo Bills host the Miami Dolphins on Prime Video at 8:15 p.m. ET. The Bills have won their first two games of the season after a 30-10 victory on the road in New York against the Jets on Sunday. The Dolphins have lost their opening two games of the year after a 33-27 upset loss at home against New England last week. Buffalo is a 12.5-point favorite with the total set at 49.5. 

Week 4 in NCAAF college football starts with one game between FBS opponents. Rice visits Charlotte on ESPN at 7:30 p.m. ET. The Owls are 2-1 this season after a 38-17 victory against Prairie View A&M on Saturday. The 49ers ended a two-game losing streak by winning their first game of the year in a 43-25 victory against Monmouth last week. Rice is a 2.5-point road favorite with an over/under of 44.5. 

Major League Baseball has 10 games on its schedule. Three MLB games throw out the first pitch at 1:10 p.m. ET. The Toronto Blue Jays play in Tampa Bay against the Rays as a -126 money-line road favorite with a total of 8.5. The New York Mets play at home against the San Diego Padres as a -132 money-line favorite with an over/under 9. The Detroit Tigers are home against the Cleveland Guardians as a -209 money-line favorite with a total of  7.5. 

The Boston Red Sox host the Athletics at 1:35 p.m. ET as a -157 money-line favorite with an over/under of 9. The Seattle Mariners are in Kansas City to take on the Royals as a -123 money-line road favorite with a total of 9. The Miami Marlins visit Colorado to face the Rockies at 3:10 p.m. ET as a -176 money-line road favorite with an over/under of 10.5. 

Two MLB games are featured on Fox’s regional coverage at 7:15 p.m. ET. The Chicago Cubs play in Cincinnati against the Reds as a -123 money-line favorite with a total of 9. The New York Yankees are in Baltimore to challenge the Orioles as a -182 money-line road favorite with an over/under of 9. The Milwaukee Brewers play at home against the Los Angeles Angels at 7:40 p.m. ET as a -187 money-line favorite with a total of 8. 

The Los Angeles Dodgers are home against the San Francisco Giants at 10:10 p.m. ET as a -164 money-line favorite with an over/under of 8. 

Matchday 1 in the UEFA Champions League concludes with six league phase matches. Two matches start at 12:45 PM ET. Monaco travels to Club Brugge as a -0.5 goal-line road favorite with a total of 2.5. Bayer Leverkusen plays at FC Copenhagen on the CBS Sports Network as a -0.5 goal-line road favorite with an over/under of 2.5.

Four matches conclude the UCL card at 3:00 PM ET. Manchester City plays at home against Napoli as a -0.5 goal-line favorite with a total of 2.5. Eintracht Frankfurt is at home against Galatasaray on the CBS Sports Network as a -0.5 goal-line favorite with an over/under of 3.5. Sporting Lisbon is home against Kayrat Almaty as a -2.5 goal-line favorite with a total of 3.5. Barcelona is at Newcastle United as a -0.5 goal-line road favorite with an over/under of 3.5. All eight Champions League matches are available on Paramount+.

All photographic images used for editorial content have been licensed from the Associated Press.

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