Big Al's Daily Angle: NFL, NCAAF and MLB Previews and Odds - 10/02/2025

by Big Al Staff

Thursday, Oct 02, 2025
The Thursday sports card features NFL, NCAAF, and MLB action. 

Week 5 in the National Football League kicks off with one game. The Los Angeles Rams host the San Francisco 49ers on Prime Video at 8:15 p.m. ET. The Rams rebounded from their loss at Philadelphia with a 27-20 victory at home against Indianapolis as a 3.5-point favorite last Sunday. They have a 3-1 record. The 49ers lost their first game of the season in a 26-24 upset loss at home against Jacksonville as a 3.5-point favorite on Sunday. They are tied with the Seattle Seahawks and Los Angeles for first place in the NFC West. The Rams are an 8.5-point favorite with the total set at 45.5 (all odds from DraftKings). 

Week 6 in NCAAF college football starts with one game between FBS opponents. San Houston travels to play New Mexico State on the CBS Sports Network at 9:00 p.m. ET. The Bearkats lost their fourth game in a row to start the season in a 55-0 loss at Texas as a 39.5-point underdog on September 20th. The Aggies have lost two games in a row after their 38-20 loss at New Mexico as a 15.5-point underdog on Saturday. They have a 2-2 record. Sam Houston is a 2.5-point favorite with an over/under of 53.5. 

Major League Baseball continues its best-of-three Wild Card round of the playoffs with three games on ESPN. The Cleveland Guardians play at home against the Detroit Tigers at 3:08 p.m. ET. The Guardians forced a decisive third game in this best-of-three series with their 6-1 victory at home against the Tigers on Wednesday. They have won 14 of their last 18 games. Detroit has lost 11 of its last 14 games. Cleveland sends out Slade Cecconi to pitch against the Tigers’ Jack Flaherty. The victor of this game travels to Toronto to play the Blue Jays in the first game of the American League Divisional Series on Saturday. The Guardians are a -113 money-line favorite with a total of 7.

The Chicago Cubs are home against the San Diego Padres at 5:08 p.m. ET. The Padres kept this series going with a 3-0 victory on the road against the Cubs yesterday. They have won eight of their last 10 games. Chicago had won four games in a row before the loss on Wednesday. Jameson Taillon takes the mound for the Cubs to pitch against Yu Darvish for San Diego. The winner of this game visits Milwaukee on Saturday in the opening game of the National League Division Series. Chicago is a -116 money-line favorite with an over/under of 7.5. 

The New York Yankees host the Boston Red Sox at 8:08 p.m. ET. The Yankees forced a final third game in this series with their 4-3 victory at home against the Red Sox on Wednesday. They have won nine of their last 10 games. The Red Sox had won two games in a row before that loss yesterday. New York taps Cam Schlittler to take the ball to duel against Boston’s Connelly Early. The winner of this game plays in Toronto in Game 1 of the ALDS on Saturday. The Yankees are a -153 money-line favorite with a total of 8. 

All photographic images used for editorial content have been licensed from the Associated Press.

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