Big Al's Daily Angle: NFL, MLB and EPL Previews and Odds - 09/28/2025

by Big Al Staff

Sunday, Sep 28, 2025
The Sunday sports card features NFL, MLB, and EPL action. 

Week 4 in the NFL continues with 13 games. The Minnesota Vikings play the Pittsburgh Steelers on the NFL Network at 9:30 a.m. ET at Crove Park in Dublin, Ireland. The Vikings are a 2.5-point road favorite with the total set at 41.5 (all odds from DraftKings). 

Seven NFL games kick off at 1:00 p.m. ET. The Atlanta Falcons host the Washington Commanders as a 1.5-point favorite with an over/under of 43.5. The Detroit Lions play at home against the Cleveland Browns as a 10-point favorite with a total of 44.5. The Los Angeles Chargers travel to New York to take on the Giants as a 6-point road favorite with an over/under of 43.5. The Houston Texans are home against the Tennessee Titans as a 7-point favorite with a total of 39.5. The New England Patriots host the Carolina Panthers as a 5.5-point favorite with an over/under of 42.5. The Buffalo Bills play at home against the New Orleans Saints as a 14.5-point favorite with a total of 48.5. The Philadelphia Eagles play in Tampa Bay against the Buccaneers as a 3.5-point road favorite with an over/under of 44.5. 

Two NFL games start at 4:05 p.m. ET. The San Francisco 49ers are at home against the Jacksonville Jaguars as a 3.5-point favorite with a total of 46.5. The Los Angeles Rams host the Indianapolis Colts at 4:05 p.m. ET as a 3.5-point favorite with an over/under of 49.5. Two more NFL games begin at 4:25 p.m. ET. The Baltimore Ravens are in Kansas City to take on the Chiefs as a 2.5-point road favorite with a total of 48.5. The Las Vegas Raiders play at home against the Chicago Bears at 4:25 p.m. ET as a 1.5-point favorite with an over/under of 48.5. 

The Green Bay Packers visit Dallas to challenge the Cowboys on NBC at 8:20 PM ET for Sunday Night Football. The Packers are a 7-point road favorite with a total of 47.5. 

Major League Baseball has 15 games on its schedule for the final day of the regular season. Six MLB games throw out the first pitch at 3:05 p.m. ET. The Boston Red Sox are home against the Detroit Tigers. The Kansas City Royals play on the road against the Athletics. The Washington Nationals host the Chicago White Sox as a -123 money-line favorite with an over/under of 8.5. The San Francisco Giants play at home against the Colorado Rockies as a -301 money-line favorite with a total of 7.5. The Philadelphia Phillies are home against the Minnesota Twins as a -208 money-line favorite with an over/under of 8. The New York Yankees host the Baltimore Orioles as a -194 money-line favorite with a total of 8.5. 

Two MLB games start at 3:07 p.m. ET. The Houston Astros are in Los Angeles to battle the Angels. The Toronto Blue Jays play at home against the Tampa Bay Rays as a -208 money-line favorite with an over/under of 7.5. 

Five MLB games begin at 3:10 p.m. ET. The Cleveland Guardians are home against the Texas Rangers. The New York Mets travel to Miami to face the Marlins as a -121 money-line road favorite with a total of 8. The Milwaukee Brewers host the Cincinnati Reds as a -150 money-line favorite with an over/under of 7.5. The Seattle Mariners play at home against the Los Angeles Dodgers as a -112 money-line favorite with a total of 8. The San Diego Padres are at home against the Arizona Diamondbacks. 

The Atlanta Braves host the Pittsburgh Pirates at 3:15 p.m. ET as a -208 money-line favorite with a total of 7.5. The Chicago Cubs play at home against the St. Louis Cardinals at 3:20 p.m. ET as a -165 money-line favorite at BetOnline with an over/under of 7.5.

Matchweek 6 in the English Premier League continues with two matches on the USA Network. Aston Villa plays at home against Fulham at 9:00 a.m. ET as a -0.5 goal-line favorite with a total of 2.5. Arsenal plays at Newcastle United at 11:30 a.m. ET as a -0.5 goal-line road favorite with an over/under of 2.5.

All photographic images used for editorial content have been licensed from the Associated Press.

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