Big Al's Daily Angle: NFL and MLB Previews and Odds - 09/22/2025

by Big Al Staff

Monday, Sep 22, 2025
The Monday sports card features NFL and MLB action. 

Week 3 in the NFL concludes with one game. The Baltimore Ravens host the Detroit Lions on ABC/ESPN/ESPN2 Manningcast at 8:15 p.m. ET. The Ravens evened their record at 1-1 with a 41-7 victory at Cleveland as a 13.5-point favorite last Sunday. The Lions are also 1-1 this season after a 52-21 win against Chicago as a 6.5-point favorite on Sunday. Baltimore is a 4.5-point favorite with the total set at 53.5 (all odds from DraftKings). 

Major League Baseball has three games scheduled. The Atlanta Braves play at home against the Washington Nationals at 7:15 p.m. ET.  The Braves have won eight games in a row after a 6-2 victory at Detroit on Sunday. The Nationals have won two games in a row after a 3-2 victory in New York against the Mets yesterday. Atlanta sends out Chris Sale to take the ball to pitch against Washington’s MacKenzie Gore. The Braves are a -259 money-line favorite with an over/under of 7. 

The San Diego Padres are home against the Milwaukee Brewers at 9:40 p.m. ET. The Padres have won two games in a row after a 3-2 victory on the road against the Chicago White Sox yesterday. The Brewers lost for the second time in their last three games in a 5-1 loss at St. Louis on Sunday. Nick Pivetta gets the ball for San Diego to take on Freddy Peralta for Milwaukee. The Padres are a -131 money-line favorite with a total of 7.

The San Francisco Giants host the St. Louis Cardinals at 9:45 p.m. ET. The Giants had lost three games in a row before a 3-1 loss in Los Angeles against the Dodgers on Sunday. The Cardinals have won two of their last three games after their victory against the Brewers yesterday. San Francisco taps Justin Verlander to duel against St. Louis’ Michael McGreevy. The Giants are a -150 money-line favorite with an over/under of 7.5. 

All photographic images used for editorial content have been licensed from the Associated Press.

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