Big Al's Daily Angle: MLB Previews and Odds - 09/24/2025

by Big Al Staff

Wednesday, Sep 24, 2025
The Wednesday sports card features MLB action. 

Major League Baseball has 15 games on its schedule. The Atlanta Braves host the Washington Nationals at 12:15 p.m. ET. The Braves send out Bryce Elder to pitch against the Nationals’ Andrew Alvarez. Atlanta is a -194 money-line favorite with the total set at 9 (all odds from DraftKings). 

The San Diego Padres play at home against the Milwaukee Brewers at 4:10 p.m. ET.  Dylan Cease takes the mound for the Padres to face Quinn Priester for the Brewers. San Diego is a -126 money-line favorite with an over/under of 7.5.

The Baltimore Orioles are home against the Tampa Bay Rays on FS1 at 6:35 p.m. ET. The Orioles tap Tyler Wells to duel against the Rays’ Shane Baz. Baltimore is a -117 money-line favorite with a total of 8.5.

Two MLB games will be thrown out the first pitch at 6:40 p.m. ET. Cleveland hosts Detroit with Tanner Bibee getting the starting assignment for the Guardians to take on Jack Flaherty for the Tigers. The Guardians are a -126 money-line favorite with an over/under of 7.5. Cincinnati plays at home against Pittsburgh, with the Reds turning to Hunter Greene to challenge the Pirates’ Paul Skenes. The Reds are a -121 money-line favorite with a total of 7. 

The Philadelphia Phillies are home against the Miami Marlins at 6:45 p.m. ET. Jesus Luzardo takes the hill for the Phillies to pitch against Ryan Weathers for the Marlins. Philadelphia is a -199 money-line favorite with an over/under of 8.5. 

The New York Yankees host the Chicago White Sox at 7:05 p.m. ET. The Yankees tap Max Fried to battle the White Sox’s Fraser Ellard. New York is a -385 money-line favorite with a total of 8. 

The Boston Red Sox travel to Toronto to face the Blue Jays at 7:07 p.m. ET. Garrett Crochet takes the ball for the Red Sox to duel against Max Scherzer for the Blue Jays. Boston is a -144 money-line road favorite with an over/under of 7.5. 

Two MLB games start at 8:05 p.m. ET. Chicago plays at home against New York on ESPN, with the Cubs sending out Matthew Boyd to challenge the Mets’ Jonah Teng. The Cubs are a -126 money-line favorite with a total of 7. Texas is home against Minnesota with Jacob deGrom taking the hill for the Rangers to pitch against Taj Bradley for the  Twins. The Rangers are a -200 money-line favorite with an over/under of 7.5. 

The Los Angeles Angels host the Kansas City Royals at 9:38 p.m. ET. The Angels tap Yusei Kikuchi to battle against the Royals’ Stephen Kolek. Los Angeles is a -123 money-line favorite with a total of 8.5.

Two more MLB games begin at 9:40 p.m. ET. Los Angeles plays at Arizona with Blake Snell taking the hill for the Dodgers to face the Diamondbacks’ Ryne Nelson. The Dodgers are a -157 money-line road favorite with an over/under of 8.5. Seattle plays at home against Colorado, with the Mariners tapping Luis Castillo to pitch against the Rockies’ Tanner Gordon. The Mariners are a -343 money-line favorite with a total of 7.5.

The San Francisco Giants are home against the St. Louis Cardinals at 9:45 p.m. ET. Robbie Ray takes the mound for the Giants to take on Sonny Gray for the Cardinals. San Francisco is a -132 money-line favorite with an over/under of 7.5.

The Houston Astros are on the road against the Athletics at 10:05 p.m. ET. The Astros have not yet named the starting pitcher who will face the Athletics’ Luis Severino. Houston is a -144 money-line road favorite with a total of 9.

All photographic images used for editorial content have been licensed from the Associated Press.

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