Big Al's Daily Angle: MLB Previews and Odds - 09/23/2025

by Big Al Staff

Tuesday, Sep 23, 2025
The Tuesday sports card features MLB action. 

Major League Baseball has 15 games on its schedule. The Tampa Bay Rays travel to Baltimore to play the Orioles at 6:35 p.m. ET. The Rays send out Ryan Pepiot to pitch against the Orioles’ Dean Kremer. Tampa Bay is a -119 money-line road favorite with the total set at 9. 

Two MLB games throw out the first pitch at 6:40 p.m. ET. Detroit plays in Cleveland with Tarik Skubal getting the ball for the Tigers to take on Gavin Williams for the Guardians. The Tigers are a -158 money-line road favorite with an over/under of 6.5. Cincinnati hosts Pittsburgh with the Reds tapping Brady Singer to duel against the Pirates’ Jovan Oviedo. The Reds are a -157 money-line favorite with a total of 8.5. 

The Philadelphia Phillies play at home against the Miami Marlins at 6:45 p.m. ET. Cristopher Sanchez takes the mound for the Phillies to face Edward Cabrera for the Marlins. Philadelphia is a -220 money-line favorite with an over/under of 8. 

The New York Yankees are home against the Chicago White Sox at 7:05 p.m. ET. The Yankees turn to Luis Gil to challenge the White Sox’s Shane Smith. New York is a -252 money-line favorite with a total of 9.

The Toronto Blue Jays host the Boston Red Sox at 7:07 p.m. ET. Kevin Gausman gets the ball for the Blue Jays to pitch against Lucas Giolito for the Red Sox. Toronto is a -168 money-line favorite with an over/under of 8. 

The Atlanta Braves play at home against the Washington Nationals at 7:15 p.m. ET. The Braves send out Hurston Waldrep to battle the Nationals’ Brad Lord. Atlanta is a -194 money-line favorite with a total of 9. 

The Chicago Cubs are home against the New York Mets on TBS at 7:40 p.m. ET. Cade Horton takes the hill for the Cubs to face David Peterson for the Mets. Chicago is a -120 money-line favorite with an over/under of 7.5. 

The Texas Rangers host the Minnesota Twins at 8:05 p.m. ET. The Rangers tap Patrick Corbin to duel against the Twins’ Zebby Matthews. Texas is a -144 money-line favorite with a total of 8.5. 

The Kansas City Royals are in Los Angeles to play the Angels at 9:38 p.m. ET. Cole Ragans gets the starting assignment for the Royals to challenge Samuel Aldegheri for the Angels. Kansas City is a -157 money-line road favorite with an over/under of 8.5. 

Two MLB games start at 9:40 p.m. ET. Los Angeles visits Arizona, with the Dodgers turning to Shohei Ohtani to take on the Diamondbacks’ Brandon Pfaadt. The Dodgers are a -163 money-line road favorite with a total of 8.5. San Diego plays at home against Milwaukee with Randy Vasquez taking the mound for the Padres to pitch against a starting pitcher yet to be named for the Brewers. 

The Seattle Mariners are home against the Colorado Rockies at 9:40 p.m. ET. Neither team has declared its starting pitcher. 

The San Francisco Giants host the St. Louis Cardinals at 9:45 p.m. ET. The Giants tap Logan Webb to duel against the Cardinals’ Andre Pallante. San Francisco is a -200 money-line favorite with an over/under of 7.5. 

The Houston Astros play on the road against the Athletics at 10:05 p.m. ET. Cristian Javier takes the mound for the Astros to challenge Jeffrey Springs for the Athletics. Houston is a -112 money-line road favorite with a total of 10. 

All photographic images used for editorial content have been licensed from the Associated Press.

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