Big Al's Daily Angle: MLB Previews and Odds - 09/16/26

by Big Al Staff

Wednesday, Sep 16, 2026
The Wednesday sports card features MLB action. 

Major League Baseball has 15 games scheduled. The Cleveland Guardians host the Chicago White Sox on ESPN at 1:10 p.m. ET. The Guardians send out Parker Messick to pitch against the White Sox’s Anthony Kay. Cleveland is a -176 money-line favorite with the total set at 8 (all odds from DraftKings).

The St. Louis Cardinals play at home against the San Francisco Giants at 1:15 p.m. ET. Matthew Liberatore gets the ball for the Cardinals to take on Anthony Molina for the Giants. St. Louis is a -163 money-line favorite with an over/under of 8. 

The New York Yankees travel to Minnesota to play the Twins at 1:40 p.m. ET. The Yankees tap Carlos Rodon to face the Twins’ Zebby Matthews. New York is a -144 money-line road favorite with a total of 8. 

The Toronto Blue Jays are at home to challenge the Detroit Tigers at 3:07 p.m. ET. Max Scherzer takes the mound for the Blue Jays to duel against Keider Montero for the Tigers. Toronto is a -126 money-line favorite with an over/under of 8.5. 

Three MLB games throw out the first pitch at 6:40 p.m. ET. Milwaukee plays in Pittsburgh with the Brewers turning to Logan Henderson to face the Pirates’ Jared Jones. The Brewers are a -137 money-line road favorite with a total of 7.5. Tampa Bay hosts the Athletics with Nick Martinez taking the hill for the Rays to challenge Brady Basso. The Rays are a -194 money-line favorite with an over/under of 8. Los Angeles is on the road in Cincinnati, with the Dodgers sending out Blake Snell to duel against the Reds’ Andrew Abbott. The Dodgers are a -206 money-line road favorite with a total of 8.5. 

The Philadelphia Phillies visit Washington to take on the Nationals at 6:45 p.m. ET. Zack Wheeler gets the starting assignment for the Phillies to pitch against Jared Simpson for the Nationals. Philadelphia is a -191 money-line road favorite with an over/under of 8.5. 

The New York Mets play at home against the Baltimore Orioles on ESPN at 7:10 p.m. ET. The Mets turn to Robert Stack to face the Orioles’ Chris Bassitt. New York is a -145 money-line favorite with a total of 8.5. 

The Chicago Cubs are at home to challenge the Atlanta Braves at 7:40 p.m. ET. Shota Imanaga gets the ball for the Cubs to take on J.R. Ritchie for the Braves. Chicago is a -143 money-line favorite with an over/under of 8.  

The Texas Rangers host the Boston Red Sox at 8:05 p.m. ET. The Rangers turn to MacKenzie Gore to battle the Red Sox’s Jake Bennett. Texas is a -115 money-line favorite with a total of 8. 

The Houston Astros play at home against the Kansas City Royals at 8:10 p.m. ET. Christian Javier takes the mound for the Astros to face Daniel Lynch IV for the Royals. Houston is a -145 money-line favorite with an over/under of 9. 

The San Diego Padres play in Colorado against the Rockies at 8:40 p.m. ET. The Padres tap Robbie Ray to pitch against the Rockies’ Mason Adams. San Diego is a -174 money-line road favorite with a total of 11.5. 

The Seattle Mariners are on the road in Los Angeles to battle the Angels at 9:38 p.m. ET. George Kirby grabs the ball for the Mariners to duel against Yusei Kikuchi for the Angels. Seattle is a -136 money-line favorite with an over/under of 8. 

The Arizona Diamondbacks are at home to battle the Miami Marlins at 9:40 p.m. ET. The Diamondbacks send out Merrill Kelly to face the Marlins’ Ryan Gusto. Arizona is a -133 money-line favorite with a total of 9. 

All photographic images used for editorial content have been licensed from the Associated Press.

© 2026 Al McMordie's BigAl.com. All Rights Reserved.