Baltimore Ravens vs Kansas City Chiefs Prediction, Preview and Odds - 09/28/2025

Game Time: 4:25 pm ET, Sunday, September 28, 2025

Venue:  GEHA Field at Arrowhead Stadium, Kansas City, MO

Where to Watch:  CBS

DraftKings:  Point Spread:  Ravens -2.5, Chiefs +2.5; Over/Under:  48.5 points

Bet365:  Point Spread:  Ravens -2.5, Chiefs +2.5; Over/Under:  48.5 points

BetMGM:  Point Spread:  Ravens -2.5, Chiefs +2.5; Over/Under:  48.5 points

Baltimore Ravens:  1-2 (3rd place, AFC North)

Kansas City Chiefs:  1-2 (4th place, AFC West)

Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in the NFL on a 19-11-1 NFL RUN for +$7,020 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Baltimore Ravens:  lost their last game at home against the Detroit Lions 38-30.

Kansas City Chiefs:  won their last game on the road against the New York Giants 22-9.

The Ravens are entering this game with a 1-2 record overall and they have a 1-0 record in their divisional games too. They are 1-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Detroit Lions 38-30. Lamar Jackson was the starting QB and he completed 21/27 passes for 288 passing yards, 3 touchdowns, and 0 interceptions. Derrick Henry led the team in rushing yards with 50 and 1 TD. Mark Andrews led the receivers with 91 receiving yards on 6 receptions and 2 TDs. Roquan Smith led the defense in that game with 6 solo tackles and 1 assisted tackle while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

The Chiefs are entering this game with a 1-2 record overall and they have a 0-1 record in their divisional games too. They are 0-1 in their home games, 1-0 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They won their last game against the New York Giants 22-9. Patrick Mahomes was the starting QB and he completed 22/37 passes for 224 passing yards, 1 touchdown, and 0 interceptions. Isiah Pacheco led the team in rushing yards with 45. Tyquan Thornton led the receivers with 71 receiving yards on 5 receptions and 1 TD. George Karlaftis led the defense in that game with 8 solo tackles and 2 assisted tackles while George Karlaftis and Chris Jones each led the defense in sacks with 1. Jaylen Watson and Christian Roland-Wallace each came away with 1 interception for them in that one.

The current betting odds have the Chiefs listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. The Chiefs haven't looked good in their games this season with their 1-2 record overall. They did have a tough schedule to open up the season, playing the Chargers and the Eagles, but now they are off their first win of the season and that will give them some momentum. It wasn't a pretty win for the Chiefs, beating the Giants 22-9, but they got out of there with the win and the defense has still looked great in all of their games. The offense hasn't looked great, but they are going to figure things out with the talent they have, and they should be getting some players back for this game. Meanwhile, the Ravens haven't looked good in their games this season with their 1-2 record overall. They have also had a really tough schedule to open up the season, but their defense has been a big issue for them. They could be 2-1, but they blew a big lead against the Bills in week 1 and they are off a 38-30 loss at home to the Lions in their last one, a game in which they could not stop the Lions offense. The Chiefs should have an easier time on offense with the way this Ravens defense has played this season, and it won't be easy for the Ravens offense against this Chiefs defense that is still very good. The best way to place a bet here is on the Chiefs to cover the spread in this game. 

Ravens Chiefs Prediction:  Our NFL Pick for Sunday, September 28, 2025 (4:25 pm ET start time) is Chiefs 24 Ravens 21.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Baltimore Ravens Kansas City Chiefs prediction, be sure to drop by every day for our weekly NFL predictions and previews.

Baltimore Ravens: 25-16 ATS in all games. 23-14 ATS as a favorite. 8-0 ATS off an upset loss as a favorite. 24-15 OVER in all games. 8-3 OVER in a road game where the total is between 42.5 and 49 points.

Kansas City Chiefs: 2-5 ATS versus poor rushing defenses - allowing 130 rushing yards/game or more. 34-48 ATS at home when playing against a team with a losing record. 11-2 1H OVER after allowing 14 points or less last game.

Baltimore Ravens:  T. Jones (DL) Injured - Knee. I. Likely (TE) Injured - Foot. N. Madubuike (DL) Injured - Neck. P. Ricard (FB) Injured - Calf. R. Stanley (OT) Injured - Ankle. K. Van Noy (LB) Injured - Hamstring. B. Washington Jr. (DL) Injured - Ankle.

Kansas City Chiefs:  X. Worthy (WR) Injured - Shoulder. A. Gillotte (DL) Injured - Elbow. M. Danna (DL) Injured - Quad. K. Fulton (CB) Injured - Ankle. N. Bolton (LB) Injured - Rib. H. Brown (WR) Injured - Ankle. B. Cook (S) Injured - Neck. C. Humphrey (C) Injured - Rib. P. Mahomes (QB) Injured - Right Wrist. C. Omenihu (DL) Injured - Chest. J. Royals (WR) Injured - Knee. J. Taylor (OT) Injured - Knee. D. Tranquill (LB) Injured - Knee.

“The biggest problem is we didn’t play good defense. There’s nobody in that locker room that thinks that’s good enough. That’s not who we are. It cannot be who we are. It’s not good enough, it’s not acceptable.” - John Harbaugh after his team’s loss against the Lions in their last game. 

“Obviously we didn’t have the start we wanted, but it’s a long season. We’ve been searching for one win and try to figure out how we can get this thing going. The main thing now is just keep working, keep stacking and try to get another, then get another win.” - Nick Bolton after their win against the Giants in their last game. 

WR Walker, Devontez

WR Bateman, Rashod

WR Flowers, Zay

TE Andrews, Mark

QB Jackson, Lamar

RB Henry, Derrick

FB Ricard, Patrick

WR Smith-Schuster, JuJu

WR Worthy, Xavier

WR Brown, Hollywood

TE Kelce, Travis

QB Mahomes, Patrick

RB Pacheco, Isiah

Passing: Lamar Jackson (722)

Rushing: Derrick Henry (242)

Receiving: Zay Flowers (231)

Touchdowns: Derrick Henry (3)

Passing: Patrick Mahomes (669)

Rushing: Patrick Mahomes (125)

Receiving: Hollywood Brown (171)

Touchdowns: Patrick Mahomes (2)

Coaches:

Baltimore Ravens: John Harbaugh (18th season)

Kansas City Chiefs: Andy Reid (13th season)