Baltimore Ravens vs Buffalo Bills Prediction, Preview and Odds - 09/07/2025

Game Time: 8:20 pm ET, Sunday, September 7, 2025

Venue:  Highmark Stadium, Orchard Park, NY

Where to Watch:  NBC

DraftKings:  Point Spread:  Ravens -1.5, Bills +1.5; Over/Under:  50.5 points

Bet365:  Point Spread:  Ravens -1, Bills +1; Over/Under:  50.5 points

BetMGM:  Point Spread:  Ravens -1, Bills +1; Over/Under:  50.5 points

Baltimore Ravens:  0-0 (AFC North)

Buffalo Bills:  0-0 (AFC East)

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Baltimore Ravens:  N/A

Buffalo Bills:  N/A

The Ravens finished last season with a 12-5 record overall and they were 4-2 in their division games too. They had a 6-2 record in their home games and had a 6-3 record in their road games where they will be in this game. Last season, their offense was averaging 30.5 points per game and their defense was allowing an average of 21.2 points per game. Their offense was also averaging 424.9 yards per game and their defense was allowing an average of 324.2 yards per game. Lamar Jackson led the team in passing yards with 4,172, Derrick Henry led the team in rushing yards with 1,921, and Zay Flowers led the team in receiving yards with 1,059.

The Bills finished last season with a 13-4 record overall and they were 5-1 in their division games too. They had an 8-0 record in their home games and had a 5-4 record in their road games where they will be in this game. Last season, their offense was averaging 30.9 points per game and their defense was allowing an average of 21.6 points per game. Their offense was also averaging 359.1 yards per game and their defense was allowing an average of 341.5 yards per game. Josh Allen led the team in passing yards with 3,731, James Cook led the team in rushing yards with 1,009, and Khalil Shakir led the team in receiving yards with 821.

The current betting odds have the Bills listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The Bills looked great last season with their 13-4 record overall which won the AFC East. They were one of the best teams in the AFC last year, but they got stopped once again in the playoffs. Meanwhile, the Ravens also looked great last season with their 12-5 record overall which won the AFC North. They were also one of the best teams in the AFC last season, but they got stopped in the playoffs and it was against this Bills team. The Ravens will definitely be looking to get their revenge here since this is the team that ended their season last year, but the Bills have just as much talent as they did last year so this isn't going to be an easy game to win. The Ravens have a really difficult offense to stop with Henry and Jackson, but the Bills were able to do it in the playoffs when it mattered most last season and they have the edge being at home for this game again. The Bills don't have a star player on offense other than Josh Allen, but that is what made them so good last season as they would take what the defense gave to them and spread the ball around. They are going to have a similar plan in this game and they will once again be very tough for this Ravens defense to stop. The Bills have the edge in this season opener being at home. The best way to place a bet here is on the Bills to cover the spread in this game. 

Ravens Bills Prediction:  Our NFL Pick for Sunday, September 7, 2025 (8:20 pm ET start time) is Bills 27 Ravens 24.

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Baltimore Ravens: 24-14 ATS in all games. 8-3 ATS as a road favorite of 7 points or less. 6-1 ATS in games played on turf. 4-1 OVER in all games where the total is greater than or equal to 49.5.

Buffalo Bills: 28-41 1H ATS against AFC North division opponents. 4-1 OVER in all games where the total is greater than or equal to 49.5. 18-11 OVER in games played on turf.

Baltimore Ravens:  P. Ricard (FB) Injured - Calf. J. Alexander (CB) Injured - Knee. I. Likely (TE) Injured - Foot. D. Faalele (OG) Injured - Illness.

Buffalo Bills:  E. Moore (WR) Injured - Personal. T. White (CB) Injured - Groin. T. Bass (K) Injured - Hip. K. Shakir (WR) Injured - Ankle. C. Benford (CB) Injured - Groin. K. Coleman (WR) Injured - Groin. D. Carter (DL) Injured - Achilles.

“Everything kind of motivates you, that’s probably true for any kind of circumstance. You’re certainly motivated by disappointment, and that’s something that motivates us.” - John Harbaugh on his team’s upcoming game against the Bills in week 1. 

"They do a really good job as far as building the roster. They're well-coached and it will be a big challenge for us." - Sean McDermott on his team’s upcoming game against the Ravens in week 1.

WR Hopkins, Deandre

WR Bateman, Rashod

WR Flowers, Zay

TE Andrews, Mark

QB Jackson, Lamar

RB Henry, Derrick

FB Ricard, Patrick

WR Palmer, Joshua

WR Coleman, Keon

WR Shakir, Khalil

TE Kincaid, Dalton

QB Allen, Josh

RB Cook, James

FB Gilliam, Reggie

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Baltimore Ravens: John Harbaugh (18th season)

Buffalo Bills: Sean McDermott (9th season)