by Rod Pearson
Friday, Oct 17, 2025
Game Time: 8:20 pm ET, Sunday, October 19, 2025
Venue: Levi's Stadium, Santa Clara, CA
Where to Watch: NBC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Falcons +1.5, 49ers -1.5; Over/Under: 47.5 points
Bet365: Point Spread: Falcons +2, 49ers -2; Over/Under: 47 points
BetMGM: Point Spread: Falcons +2, 49ers -2; Over/Under: 47 points
Season Record
Atlanta Falcons: 3-2 (2nd place, NFC South)
San Francisco 49ers: 4-2 (1st place, NFC West)
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Recent Form
Atlanta Falcons: won their last game at home against the Buffalo Bills 24-14.
San Francisco 49ers: lost their last game on the road against the Tampa Bay Buccaneers 30-19.
Atlanta Falcons vs San Francisco 49ers Preview and Analysis
The Falcons are entering this game with a 3-2 record overall and they have a 0-2 record in their divisional games too. They are 2-1 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Buffalo Bills 24-14. Michael Penix Jr. was the starting QB and he completed 20/32 passes for 250 passing yards, 1 touchdown, and 0 interceptions. Bijan Robinson led the team in rushing yards with 170 and 1 TD. Drake London led the receivers with 158 receiving yards on 10 receptions and 1 TD. Mike Hughes led the defense in that game with 5 solo tackles and 1 assisted tackle while Dee Alford, David Onyemata, Sam Roberts, and Ruke Orhorhoro each led the defense in sacks with 1. Dee Alford and DeAngelo Malone each came away with 1 interception for them in that one.
The 49ers are entering this game with a 4-2 record overall and they have a 3-0 record in their divisional games too. They are 1-1 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Tampa Bay Buccaneers 30-19. Mac Jones was the starting QB and he completed 27/39 passes for 347 passing yards, 0 touchdowns, and 2 interceptions. Christian McCaffrey led the team in rushing yards with 54 and 1 TD. Kendrick Bourne led the receivers with 142 receiving yards on 5 receptions. Tatum Bethune led the defense in that game with 5 solo tackles and 5 assisted tackles while Mykel Williams led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Falcons vs 49ers Prediction
The current betting odds have the Falcons listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The Falcons have looked really good in their games this season with their 3-2 record overall which has them right near the top of the NFC South. They didn't have a great start to the season, but they figured some things out during their bye week and they have looked a lot better as of late. They are off a 24-14 win over the Bills in their last one and their offense has been starting to roll now. Meanwhile, the 49ers have looked really good in their games this season with their 4-2 record overall which has them right at the top of the NFC West. They have been getting by with a backup QB and a ton of other injuries too, but those injuries are starting to pile up now. They are off a 30-19 loss to the Buccaneers in their last one and they lost some more key players in that game. Their offense has already taken a big hit as there isn't a ton of talent left to get the ball too, and the same goes for their defense now too. The Falcons are starting to roll now with a lot of momentum on their side and they are in a much better situation here with a very healthy team. The 49ers had a terrible season last year that was plagued by many injuries, and this season looks like it is starting to head in the same direction. The best way to place a bet here is on the Falcons to cover the spread in this game.
Falcons 49ers Prediction: Our NFL Pick for Sunday, October 19, 2025 (8:20 pm ET start time) is Falcons 24 49ers 13.
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NFL Betting Trends
Atlanta Falcons: 17-9 ATS after playing on Monday night football. 28-18 ATS on the road after a game with a turnover margin of +2 or better. 33-17 OVER against NFC West division opponents. 21-14 OVER on the road versus poor rushing teams - averaging 90 rushing yards/game or less.
San Francisco 49ers: 7-14 ATS in home games. 1-9 ATS in a home game where the total is greater than or equal to 45.5. 5-13 ATS after playing their last game on the road. 8-1 OVER when playing against a good team (Win Pct. 60% to 75%). 13-3 OVER versus good offensive teams - averaging 350 yards/game or more.
Key Injuries
Atlanta Falcons: R. McCloud III (WR) Injured - Not Injury Related. J. Fuller (S) Injured - Knee. T. Graham (DL) Injured - Calf. L. London (DL) Injured - Triceps. D. Mooney (WR) Injured - Hamstring. F. Franks (TE) Injured - Calf. J. Walker (DL) Injured - Groin. C. Phillips III (CB) Injured - Triceps. B. Bowman Jr. (CB) Injured - Hamstring. L. Floyd (DL) Injured - Illness. J. Matthews (OT) Injured - Ankle.
San Francisco 49ers: M. Valdes-Scantling (WR) Injured - Calf. T. Williams (OT) Injured - Rest. C. McCaffrey (RB) Injured - Rest. G. Kittle (TE) Injured - Hamstring. M. Jones (QB) Injured - Knee. F. Warner (LB) Injured - Ankle. K. Davis (DL) Injured - Hand. K. Givens (DL) Injured - Pectoral. Y. Gross-Matos (DL) Injured - Knee. J. Jennings (WR) Injured - Ankle. B. Purdy (QB) Injured - Toe. S. Moore (WR) Injured - Ankle. R. Green (CB) Injured - Neck. D. Puni (OG) Injured - Knee. R. Pearsall (WR) Injured - Knee. J. Watkins (WR) Injured - Calf. U. Stout (CB) Injured - Shoulder. M. Williams (DL) Injured - Thumb. C. West (DL) Injured - Thumb.
Notable Quotes
“We've been waiting for that moment.” - Raheem Morris after his team’s win against the Bills in their last game.
“Obviously didn't play my best. I'm proud we went out there and fought. I just want to go out there and practice and see what I can do better.” - Mac Jones after their loss against the Buccaneers in their last game.
Starting Lineups
Atlanta Falcons
WR Washington, Casey
WR Sills V, David
WR London, Drake
TE Pitts Sr., Kyle
QB Penix Jr., Michael
RB Robinson, Bijan
San Francisco 49ers
WR Bourne, Kendrick
WR Robinson, Demarcus
WR Jennings, Jauan
TE Tonges, Jake
QB Jones, Mac
RB McCaffrey, Christian
FB Juszczyk, Kyle
Statistical Leaders
Atlanta Falcons
Passing: Michael Penix Jr. (1,168)
Rushing: Bijan Robinson (484)
Receiving: Drake London (427)
Touchdowns: Bijan Robinson (3)
San Francisco 49ers
Passing: Mac Jones (1,252)
Rushing: Christian McCaffrey (336)
Receiving: Christian McCaffrey (444)
Touchdowns: Christian McCaffrey (4)
Coaches:
Atlanta Falcons: Raheem Morris (2nd season)
San Francisco 49ers: Kyle Shanahan (9th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
