Atlanta Falcons vs Arizona Cardinals Prediction, Preview and Odds - 12/21/2025

 

Game Time: 4:05 pm ET, Sunday, December 21, 2025

Venue:  State Farm Stadium, Glendale, AZ

Where to Watch:  FOX

DraftKings:  Point Spread:  Falcons -2.5, Cardinals +2.5; Over/Under:  47.5 points

Bet365:  Point Spread:  Falcons -2.5, Cardinals +2.5; Over/Under:  48 points

BetMGM:  Point Spread:  Falcons -2.5, Cardinals +2.5; Over/Under:  48 points

Atlanta Falcons:  5-9 (3rd place, NFC South)

Arizona Cardinals:  3-11 (4th place, NFC West)

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Atlanta Falcons:  won their last game on the road against the Tampa Bay Buccaneers 29-28.

Arizona Cardinals:  lost their last game on the road against the Houston Texans 40-20.

The Falcons are entering this game with a 5-9 record overall and they have a 2-3 record in their divisional games too. They are 2-4 in their home games, 3-4 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Tampa Bay Buccaneers 29-28. Kirk Cousins was the starting QB and he completed 30/44 passes for 373 passing yards, 3 touchdowns, and 0 interceptions. Bijan Robinson led the team in rushing yards with 93 and 1 TD. Kyle Pitts led the receivers with 166 receiving yards on 11 receptions and 3 TDs. Jessie Bates III led the defense in that game with 6 solo tackles and 2 assisted tackles while James Pearce Jr. led the defense in sacks with 2. Dee Alford came away with the only interception for them in that one.

 

 

 

The Cardinals are entering this game with a 3-11 record overall and they have a 0-5 record in their divisional games too. They are 1-6 in their home games, 2-5 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Houston Texans 40-20. Jacoby Brissett was the starting QB and he completed 27/40 passes for 249 passing yards, 3 touchdowns, and 1 interception. Michael Carter led the team in rushing yards with 56. Trey McBride led the receivers with 134 receiving yards on 12 receptions and 2 TDs. Garrett Williams and Budda Baker each led the defense in that game with 5 solo tackles and 3 assisted tackles while Walter Nolen led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have the Falcons listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. The Falcons haven't looked good in their games this season with their 5-9 record overall which has them right near the bottom of the NFC South. They haven't been a great road team either with their 3-4 road record this year. Meanwhile, the Cardinals have looked terrible in their games this season with their 3-11 record overall which has them right at the bottom of the NFC West with one of the worst records in the NFL. They have looked terrible on their home field too with their 1-6 home record this season. The Cardinals have been a disaster all season with Jacoby Brissett taking over for an injured Kyler Murray and the team dealing with a ton of injuries all over. They don't have a lot of talent on offense that is still healthy, and their defense has looked terrible lately with the number of points they have been giving up in their games. They are off a 40-20 loss to the Texans in their last one and lately they haven't even looked competitive in their games. The Falcons haven't had the season they wanted and they lost their starting QB to injury too, but Cousins hasn't looked bad in this offense when he has had to play. The defense hasn't looked great lately, but they should look a lot better against this Cardinals offense. The Falcons are also off a 29-28 win over the Buccaneers in their last one so they have been showing signs of life and will have some momentum from that win. The best way to place a bet here is on the Falcons to cover the spread in this game. 

Falcons Cardinals Prediction:  Our NFL Pick for Sunday, December 21, 2025 (4:05 pm ET start time) is Falcons 27 Cardinals 17.

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Atlanta Falcons: 0-4 ATS against NFC West division opponents. 9-19 ATS as a favorite. 5-14 ATS after playing their last game on the road. 5-2 OVER off a win against a division rival.

Arizona Cardinals: 22-16 ATS as an underdog. 7-4 ATS after 3 or more consecutive losses. 3-0 ATS against NFC South division opponents. 15-5 OVER in a home game where the total is between 42.5 and 49 points.

Atlanta Falcons:  None.

Arizona Cardinals:  None.

“Pro Football tests you. It keeps me on my knees (in prayer). It’s been a difficult two years since tearing my Achilles. All I know to do is trust and keep going and walk by faith, not by sight, and that can be hard sometimes. Nights like tonight, you get a boost.” - Kirk Cousins after their win against the Buccaneers in their last game. 

“We got beat by a good football team. We didn’t play well enough, and we’re going to go back to work.” - Jonathan Gannon after his team’s loss against the Texans in their last game. 

WR Mooney, Darnell 

WR Sills V, David

WR Drummond, Dylan

TE Pitts Sr., Kyle

QB Cousins, Kirk

RB Robinson, Bijan

WR Brooks, Jalen

WR Wilson, Michael

TE McBride, Trey

QB Brissett, Jacoby

RB Carter, Michael

Passing: Michael Penix Jr. (1,982)

Rushing: Bijan Robinson (1,174)

Receiving: Drake London (810)

Touchdowns: Tyler Allgeier (8)

Passing: Jacoby Brissett (2,708)

Rushing: Bam Knight (269)

Receiving: Trey McBride (1,071)

Touchdowns: Trey McBride (10)

Coaches:

Atlanta Falcons: Raheem Morris (2nd season)

Arizona Cardinals: Jonathan Gannon (3rd season)