Arizona Wildcats vs Iowa State Cyclones Prediction, Picks and Game Preview - 09/27/2025

Game Time: 7:00 pm ET, Saturday, September 27, 2025

Venue:  Jack Trice Stadium, Ames, IA 

Where to Watch:  ESPN

DraftKings:  Point Spread:  Arizona +6.5, Iowa State -6.5; Over/Under:  48.5 points

Bet365:  Point Spread:  Arizona +6.5, Iowa State -6.5; Over/Under:  49 points

BetMGM:  Point Spread:  Arizona +6.5, Iowa State -6.5; Over/Under:  48.5 points

Arizona Wildcats:  3-0 (0-0) (9th place, Big 12)

Iowa State Cyclones:  4-0 (1-0) (2nd place, Big 12)

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Arizona Wildcats:  won their last game at home against the Kansas State Wildcats 23-17.

Iowa State Cyclones:  won their last game on the road against the Arkansas State Red Wolves 24-16.

Arizona is entering this game with a 3-0 record overall and they have a 0-0 record in their conference games too. They are 3-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Kansas State 23-17. Noah Fifita was the starting QB and he completed 16/33 passes for 178 passing yards, 0 touchdowns, and 0 interceptions. Ismail Mahdi led the team in rushing yards with 189. Chris Hunter led the receivers with 37 receiving yards on 3 receptions. Genesis Smith led the defense in that game with 4 solo tackles and 4 assisted tackles while Deshawn McKnight and Treydan Stukes each led the defense in sacks with 0.5. No one on the defense came away with an interception for them in that one.

 

 

 

Iowa State is entering this game with a 4-0 record overall and they have a 1-0 record in their conference games too. They are 2-0 in their home games, 1-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Arkansas State 24-16. Rocco Becht was the starting QB and he completed 14/25 passes for 265 passing yards, 1 touchdown, and 1 interception. Carson Hansen led the team in rushing yards with 116. Xavier Townsend led the receivers with 92 receiving yards on 3 receptions. Kooper Ebel and Ta'Shawn James each led the defense in that game with 5 solo tackles and 0 assisted tackles while Ikenna Ezeogu and Jace J. Gilbert each led the defense in sacks with 1. Tre Bell came away with the only interception for them in that one.

The current betting odds have Iowa State listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. Iowa State has looked great in their games this season with their 4-0 record overall and their 1-0 conference record which has them right near the top of the Big 12. They haven't played any top teams in the nation yet, but they haven't had an easy schedule to start the season either. They opened the year with a big conference win in Ireland over Kansas State and they won a tough game against Iowa who always comes to play against them. They have definitely been tested in their first few games and now they will be looking to pick up another conference win here and really put their stamp on the Big 12 early on. They have looked like the team to beat in the conference so far and they are playing with a chip on their shoulder after the way things ended last year. Meanwhile, Arizona has looked really good in their games this season with their 3-0 record overall, but they haven't really been tested by any strong opponents either. They have a win over a conference opponent in their last one which didn't count toward the conference schedule, but they barely beat a bad Kansas State team at home. Arizona has also played all 3 of their games this season at home so this is going to be their first road test of the season and it isn't going to be an easy game for them. The best way to place a bet here is on Iowa State to cover the spread in this game. 

Arizona Iowa State Prediction:  Our NCAAF Pick for Saturday, September 27, 2025 (7:00 pm ET start time) is Iowa State 34 Arizona 27.

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Arizona Wildcats: 4-1 ATS when the total is between 42.5 and 49. 6-3 ATS off a win against a conference rival. 7-1 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 7-3 UNDER off a home win. 

Iowa State Cyclones: 3-6 ATS vs. good passing teams averaging 8 or more passing yards/att. 1-5 ATS when playing against a top-level team (Win Pct. > 75%). 10-5 UNDER in home lined games. 

Arizona Wildcats:  R. Wilson (LB) Questionable - Undisclosed. K. Reescano (RB) Questionable - Undisclosed. T. Powell (TE) Out - Leg.

Iowa State Cyclones:  G. Burkle (TE) Questionable - Undisclosed. K. Konrardy (K) Questionable - Undisclosed. M. Chapman (DL) Questionable - Undisclosed. W. Archer (CB) Questionable - Undisclosed. C. Willich (LB) Questionable - Undisclosed. D. Hasert (OG) Questionable - Undisclosed. L. Hicks II (CB) Questionable - Undisclosed. R. Peppers (RB) Questionable - Undisclosed. S. Zelenovich (WR) Questionable - Undisclosed. J. Klosterman (LB) Questionable - Undisclosed. J. Jackson (RB) Questionable - Undisclosed. W. Tompkins (OG) Questionable - Undisclosed. D. Jensen (OG) Questionable - Undisclosed. S. Same (LB) Questionable - Undisclosed. M. Parkes (WR) Questionable - Undisclosed. M. Sat (OG) Questionable - Undisclosed. E. Stecker (CB) Questionable - Undisclosed.

“That's what it's supposed to look like. Not the whole thing, but in moments that's what it's supposed to look like and I'm so proud of this team.” - Brent Brennan after his team’s win against KSU in their last game. 

“In the moment, you trust that guy with everything you have because of who he is. He just keeps proving it time after time after time.” - Matt Campbell after his team’s win against Arkansas State in their last game. 

WR Hutson, Kris

WR Hunter, Chris

WR Wysong, Luke

WR Whatley, Javin

TE Olson, Sam

QB Fifita, Noah

RB Craig, Quincy

WR Sowell, Chase

WR Eskildsen, Brett

WR Overby, Dominic

TE Burkle, Gabe

TE Brahmer, Benjamin

QB Becht, Rocco

RB Hansen, Carson

Passing: Noah Fifita (712)

Rushing: Ismail Mahdi (263)

Receiving: Javin Whatley (237)

Touchdowns: Noah Fifita (3)

Passing: Rocco Becht (860)

Rushing: Carson Hansen (252)

Receiving: Brett Eskildsen (162)

Touchdowns: Benjamin Brahmer (3)

Coaches:

Arizona Wildcats: Brent Brennan (2nd season)

Iowa State Cyclones: Matt Campbell (10th season)